Epidermal Permeability Barrier Recovery Is Delayed in Vitiligo-Involved Sites

Liu, J.; Man, Wenyan; Lv, Chengzhi; Shu-min, Song; Shi, Yu; Elias, Peter M.; Man, Mao‐Qiang

doi:10.1159/000288166

Cited by 37 publications

(46 citation statements)

References 141 publications

(90 reference statements)

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“…Melanin indices of histamine- and vehicle-treated sites, as well as contralateral, uninvolved normal skin sites were measured at baseline using a Mexameter® MX 18 probe connected to a Multiprobe Adapter System (Courage-Khazaka, Cologne, Germany), and again after 5 weeks of treatments [29]. Melanin indices were expressed as percentage of normal skin, calculated according to the equation: (lesion melanin index/contralateral normal skin) × 100.…”

Section: Methodsmentioning

confidence: 99%

“…Reduction in lesion size was calculated using the equation: (pretreatment weight - posttreatment weight)/pretreatment × 100. Transepidermal water loss rates, an indicator of epidermal permeability barrier function in lesions, were measured with a TM300 probe, connected to a Courage-Khazaka MPA5 prior to and after 5 weeks of treatments, as described previously [29]. After 5 weeks of treatments, the barrier recovery rate was assessed 3 h after acute barrier perturbation by sequential D-squame applications [29].…”

Section: Methodsmentioning

confidence: 99%

“…In part due to uncertainty about its etiology, optimal treatments are not yet available, although many approaches, including laser, high-potency topical steroids, topical immunomodulators, herbal medicines, as well as melanocyte/epidermal transplantation have yielded mixed results [13,14,15,16,17,18,19,20]. Notably, the efficacy of most of these regimens is not only moderate, but also costly [21,22], and can provoke substantial side effects such as skin infections [23,24,25,26], skin atrophy, and/or disturbed epidermal permeability barrier homeostasis [27,28], which is already compromised in vitiligo [29]. …”

Section: Introductionmentioning

confidence: 99%

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Topical Histamine Stimulates Repigmentation of Nonsegmental Vitiligo by a Receptor-Dependent Mechanism

Li¹,

Xu²,

Lin

et al. 2017

Skin Pharmacol Physiol

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Background: Though vitiligo is a common depigmentary disorder, it still represents a substantial therapeutic challenge. Therapeutic options are limited in part due to its uncertain etiology. Objective: Because recent studies suggest that histamine stimulates melanogenesis in vitro, we determined here whether topical histamine stimulates repigmentation in patients with stable, nonsegmental vitiligo. Methods: A total of 23 otherwise normal volunteers with vitiligo, including 14 males and 9 females aged 6-59 years (mean age 29.2 ± 2.8), were enrolled in this study. 1% histamine in distilled water was applied to the lesions twice daily for 5 weeks, while comparable lesions, treated with distilled water alone, served as the controls. The melanin index was measured on the uninvolved and lesional skin sites before and after 5 weeks of treatments using the melanin/erythema probe connected to a Courage-Khazaka MPA5 (Cologne, Germany). Changes in epidermal permeability barrier were also assessed at the same time point. To determine whether histamine-induced repigmentation is receptor-dependent, both ears of C57BL/6J mice were treated topically with 5% cimetidine, a histamine type 2 receptor (H2r) antagonist, twice daily for 10 days. One hour after each cimetidine application, the right ear was treated topically with 10% histamine, while vehicle alone was applied to the left ear. Changes in melanin index were measured 24 h after the last application of histamine and vehicle as described in the human study. Results: In patients with vitiligo treated with vehicle alone for 5 weeks, the melanin index remained unchanged, while topical histamine treatment increased the melanin index by 38% (p < 0.001 vs. both vehicle and pretreatment), which was paralleled by a >60% reduction in lesion surface area. Moreover, topical histamine accelerated permeability barrier recovery. No adverse events were observed following histamine applications. In mice, topical histamine significantly increased the melanin index, while topical co-applications of the H2r antagonist (cimetidine) prevented the expected histamine-induced increase in melanin index. Conclusions: These studies indicate that topical histamine or an H2r agonist could be useful for treating nonsegmental vitiligo, but further clinical studies in large populations will be required to validate the efficacy and safety of this approach.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Topical Histamine Stimulates Repigmentation of Nonsegmental Vitiligo by a Receptor-Dependent Mechanism

Li¹,

Xu²,

Lin

et al. 2017

Skin Pharmacol Physiol

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“…When comparing the response of skin affected by vitiligo to contra lateral unaffected skin using tape stripping, Liu et al 44 found that barrier recovery was delayed in vitiligo as measured by transepidermal water loss. This would be a failure of the main function of keratinocytes and supports the view that for vitiligo, we must examine the keratinocyte.…”

Section: Lerner's Theory Of Self-destructionmentioning

confidence: 99%

Disorders of Pigmentation of the Skin - Hypotheses Underlying Interventions by Multiple Systems of Medicine:Is there a Role for Integrated Medicine?

Arianayagam

Ryan

2016

Current Science

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Biomedicine has not provided a complete explanation with fully effective therapies for disorders of pigmentation. Biomedicine emphasizes the role of melanocyte for protection from UV rays and as a determinant of skin colour. These important properties acquired a genetic basis much later than other functions, many relating to cell contact as in the keratinocyte -melanocyte unit, or as with the synapses of the neurological system. There are other roles, biochemical and mechanical, of melanocyte. Management that is inclusive of a maximally holistic approach justifies the use of diverse herbals, yoga and concern for cultural awareness provided by integrated medicine. Vitiligo provides a model which demonstrates that Ayurveda has a richer view of its presentations, possibly a stronger line on its pathogenesis, and a huge range of herbals, many now backed by studies from ethnobotanical laboratories, awaiting research into the many possible mechanisms by which they may act in the wide and complex field of melanocyte biochemistry.

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“…In the present study, TEWL measurements were compared to in vivo laser scanning microscopic measurements (LSM), in order to study the skin barrier function and the structure of the SC [18,19]. Additionally, the skin elasticity and the SC hydration were analyzed.…”

Section: Biophotonicsmentioning

confidence: 99%

Comparison between TEWL and laser scanning microscopy measurements for the in vivo characterization of the human epidermal barrier

Vergou

Schanzer

Richter

et al. 2011

Journal of Biophotonics

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The analysis of the skin barrier properties is important in various fields of medical treatment and cosmetology. The development and improvement of topically applied substances require an objective analysis of the skin barrier characteristics. Transepidermal water loss (TEWL) measurement is the standard method to characterize epidermal barrier function. The most important disadvantage of this method though, is that it can be affected by different exogenous and endogenous factors, e.g. water content of the applied formulation and room temperature. In the present study, TEWL measurements are compared to laser scanning microscopic (LSM) measurements, concerning the use of these two methods for the non‐invasive in vivo characterization of the epidermal barrier function. The investigations were performed prior and subsequent to treatment of dry skin with a gel mixture, developed for skin treatment after radiotherapy for cancer. The present results indicate that in vivo laser scanning microscopy is an appropriate method for the characterization of the skin barrier structure without interference by external factors. (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)

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Epidermal Permeability Barrier Recovery Is Delayed in Vitiligo-Involved Sites

Cited by 37 publications

References 141 publications

Topical Histamine Stimulates Repigmentation of Nonsegmental Vitiligo by a Receptor-Dependent Mechanism

Topical Histamine Stimulates Repigmentation of Nonsegmental Vitiligo by a Receptor-Dependent Mechanism

Disorders of Pigmentation of the Skin - Hypotheses Underlying Interventions by Multiple Systems of Medicine:Is there a Role for Integrated Medicine?

Comparison between TEWL and laser scanning microscopy measurements for the in vivo characterization of the human epidermal barrier

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