Epidermotropic metastasis from vulvar squamous cell carcinoma: A rare cutaneous manifestation

Wang, Annie; O’Brien, Meghan; Ross, Rustin; Long, Thomas J.; Robinson‐Bostom, Leslie

doi:10.1016/j.jaad.2009.07.036

Cited by 14 publications

(6 citation statements)

References 29 publications

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“…258 Immunohistochemically, adenocarcinomas of endocervix are usually positive for CK7 and negative for CK20, whereas squamous cell carcinomas of this site are negative for both the markers. 259 71 Cutaneous metastases from vulvar cancers are very rare, and less than 10 cases have been reported.…”

Section: Carcinoma Of the Uterine Cervix And Vaginamentioning

confidence: 99%

Cutaneous Metastases From Internal Malignancies

Alcaraz

Cerroni

Rütten

et al. 2012

The American Journal of Dermatopathology

225

104

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Skin metastases occur in 0.6%-10.4% of all patients with cancer and represent 2% of all skin tumors. Skin metastases from visceral malignancies are important for dermatologists and dermatopathologists because of their variable clinical appearance and presentation, frequent delay and failure in their diagnosis, relative proportion of different internal malignancies metastasizing to the skin, and impact on morbidity, prognosis, and treatment. Another factor to take into account is that cutaneous metastasis may be the first sign of clinically silent visceral cancer. The relative frequencies of metastatic skin disease tend to correlate with the frequency of the different types of primary cancer in each sex. Thus, women with skin metastases have the following distribution in decreasing order of frequency of primary malignancies: breast, ovary, oral cavity, lung, and large intestine. In men, the distribution is as follows: lung, large intestine, oral cavity, kidney, breast, esophagus, pancreas, stomach, and liver. A wide morphologic spectrum of clinical appearances has been described in cutaneous metastases. This variable clinical morphology included nodules, papules, plaques, tumors, and ulcers. From a histopathologic point of view, there are 4 main morphologic patterns of cutaneous metastases involving the dermis, namely, nodular, infiltrative, diffuse, and intravascular. Generally, cutaneous metastases herald a poor prognosis. The average survival time of patients with skin metastases is a few months. In this article, we review the clinicopathologic and immunohistochemical characteristics of cutaneous metastases from internal malignancies, classify the most common cutaneous metastases, and identify studies that may assist in diagnosing the origin of a cutaneous metastasis.

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Section: Carcinoma Of the Uterine Cervix And Vaginamentioning

confidence: 99%

Cutaneous Metastases From Internal Malignancies

Alcaraz

Cerroni

Rütten

et al. 2012

The American Journal of Dermatopathology

225

104

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“…In Table 1, all of previous patients as well as the present case are shown. All of the 10 cases had isolated skin metastasis except 1 case, which had skin and groin lymph nodes metastases simultaneously (8). Traditionally isolated skin metastasis is described as the implantation of malignant cells due to destruction of lymphatic canals caused by cancer, surgery, and radiation (9).…”

Section: Discussionmentioning

confidence: 99%

A Unique History of the First Cases with Simultaneous Bone and Skin Metastasis in Vulvar Squamous Cell Carcinoma

Nasiri

Mousavi

Hasani

et al. 2017

J Obstet Gynecol Cancer Res

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Introduction: The incidence of vulvar cancer is nearly 5% of all gynecologic malignancies and almost 95% of vulvar cancers are squamous cell carcinoma (SCC). Recurrence is possible in 4 ways: local, regional, pelvic, and distant. In a cohort of 391 patients with vulvar SCC, distant metastasis was reported 5% .The common sites of distant metastasis are pelvic nodes, lung, and liver. Both skin and bone metastasis are rare in vulvar SCC. Case Presentation: The current report presented a 58-year-old female with the diagnosis of vulvar SCC. She was the 11th cutaneous metastasis, 13th bone metastasis, and the 1st case with simultaneous bone and skin metastasis reported in the last 60 years. Conclusions: It is necessary to consider any lesion on the vulve, especially in menopause females, and it should be the low threshold for biopsy to avoid delay in detection. After completion of selective treatment, the exact follow-up should be considered to discover metastases.

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“…Vulvar SCC can metastasize through direct extension to neighboring structures, lymphatic spread to regional lymph nodes, or hematogenous dissemination to distant sites. 3 Cutaneous metastases from vulvar malignancies are exceedingly rare, with fewer than 10 cases reported in the literature to date. 3 Cutaneous metastases from vulvar SCC, in particular, have presented as multiple, disseminated violaceous nodules, erythematous tumors, and lymphangioma circumscriptum.…”

Section: Discussionmentioning

confidence: 99%

“… 3 Cutaneous metastases from vulvar malignancies are exceedingly rare, with fewer than 10 cases reported in the literature to date. 3 Cutaneous metastases from vulvar SCC, in particular, have presented as multiple, disseminated violaceous nodules, erythematous tumors, and lymphangioma circumscriptum. 4 , 5 This case represents a unique morphologic presentation of cutaneous metastases from vulvar SCC masquerading as a recurrent vesicular HSV infection.…”

Section: Discussionmentioning

confidence: 99%