2020
DOI: 10.1093/jnci/djaa147
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Epigenetic Age Acceleration and Chronic Health Conditions Among Adult Survivors of Childhood Cancer

Abstract: Background Mounting evidence supports the occurrence of accelerating aging among long-term survivors of childhood cancer. We aimed to investigate epigenetic age acceleration (EAA) in survivors and evaluate associations between EAA, treatment exposures, health behaviors, and chronic health conditions (CHCs). Methods Genome-wide methylation data were generated with Infinium EPIC BeadChip on blood-derived DNA from 2139 survivors… Show more

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Cited by 50 publications
(96 citation statements)
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“…SJLIFE participants ( n =2922) with pre-exiting whole-genome sequencing data [ 20 , 21 ] were included in the current study. The first discovery data set, denoted as SJLIFE1 Survivors, included 2138 survivors previously scanned with EPIC array [ 6 ]. The second discovery data set, denoted as SJLIFE2 survivors, included 502 survivors newly scanned with EPIC array in an expansion study focused primarily on childhood and adolescent survivors.…”
Section: Methodsmentioning
confidence: 99%
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“…SJLIFE participants ( n =2922) with pre-exiting whole-genome sequencing data [ 20 , 21 ] were included in the current study. The first discovery data set, denoted as SJLIFE1 Survivors, included 2138 survivors previously scanned with EPIC array [ 6 ]. The second discovery data set, denoted as SJLIFE2 survivors, included 502 survivors newly scanned with EPIC array in an expansion study focused primarily on childhood and adolescent survivors.…”
Section: Methodsmentioning
confidence: 99%
“…The third exploratory data set, denoted Community Controls, included 282 controls with no history of childhood cancer, who were enrolled in SJLIFE study and frequency matched to the survivors by age, sex, and race. This set of controls was also previously scanned with an EPIC array [ 6 ].…”
Section: Methodsmentioning
confidence: 99%
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“…These changes resemble an aging phenotype observed in older populations [ 128 ] and are indicative of allostatic load [ 127 ]. Some research shows that pediatric cancer survivors have increased biological age relative to their chronological age, as indicated by shortened telomeres [ 104 , 105 ], epigenetic age acceleration [ 106 ] and biochemical and molecular markers such as inefficient oxidative phosphorylation, increased lipid peroxidation and decreased expression of metabolic proteins and those involved in mitochondrial biogenesis [ 107 ]. Childhood cancer survivors also report an increased incidence of premature frailty associated with radiation treatment [ 108 ].…”
Section: Target Organ Activationmentioning
confidence: 99%