Epigenetic Control Systems

Nanney, D. L.

doi:10.1073/pnas.44.7.712

Cited by 319 publications

(130 citation statements)

References 6 publications

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“…At higher levels of biological organization, epigenetic mechanisms generate the context-dependent, selfsustaining interactions between groups of cells that lead to physiological and morphological persistence. The regulatory mechanisms that establish and maintain variant cellular and organismal states are known as epigenetic control mechanisms, or epigenetic control systems (Nanney 1958).…”

mentioning

confidence: 99%

Transgenerational Epigenetic Inheritance: Prevalence, Mechanisms, and Implications for the Study of Heredity and Evolution

Jablonka

Raz²

2009

The Quarterly Review of Biology

1,429

1,179

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mentioning

confidence: 99%

Transgenerational Epigenetic Inheritance: Prevalence, Mechanisms, and Implications for the Study of Heredity and Evolution

Jablonka

Raz²

2009

The Quarterly Review of Biology

1,429

1,179

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“…From a historical perspective, the definition of the term has metamorphosed over the years from its original coinage and meaning by Slack (13). More than 10 years later, another author defined 'epigenetic systems' as supportive processes involved in ascertaining the specific genes that will be expressed in any individual cell (14). Following the identification of heritable models of DNA methylation, the hypothesis that epigenetic characteristics were inherited as controlling indicators coupled with the genome predominated.…”

Section: Epigenetics: Definition and Pathophysiologymentioning

confidence: 99%

Chronic kidney disease in children and the role of epigenetics: Future therapeutic trajectories

et al. 2016

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Abstract. Global differences in the observed causes of chronic kidney disease (CKD) in children are well documented and are attributed to dissimilarities in clime, race, hereditary, and ancestry. Thus, familial clustering and disparities in CKD prevalence rates across ethnic and racial groups indicate that the progression of renal disease has a strong genetic component. Mammalian studies have demonstrated a feasible nexus between nutrition and non-genetic exposure (around the time of conception and in epigenetic changes) in the expression of major genes identified in renal organogenesis. The major consequence is a reduction in the number of nephrons, with subsequent predisposition to hypertension and CKD.

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“…This further layer of information for regulating the differential gene expression was early described as 'epigenetic control' by Nanney in 1958 [8]. Although there is a little debate on the precise description of epigenetics, the fundamental definition of epigenetics refers to the heritable changes in cell or tissue specific gene expression with no alteration in the DNA sequences [6].…”

Section: Introductionmentioning

confidence: 99%

The Contribution of Next Generation Sequencing Technologies to Epigenome Research of Stem Cell and Tumorigenesis

Li¹

2013

Human Genet Embryol

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Epigenome contains another layer of genetic information, not as stable as genome. Dynamic epigenome can serve as an interface to explain the role of environmental factors. Stem cell and tumorigenesis are reported to be closely associated with epigenome modifications. Next generation sequencing (NGS) technologies have directly leaded to the recent advances in epigenome research of stem cell and cancer. DNA methylation and histone modification are two major epigenetic modifications. Four NGS-based approaches have been developed to identify these two epigenetic modifications, including whole genome bisulfite sequencing (WGBS), methylated DNA Immunoprecipitation Sequencing (MeDIP-Seq), reduced representation bisulfite sequencing (RRBS) and chromatin immunoprecipitation sequencing (ChIP-Seq). This paper reviews the recent advances of WGBS, MeDIP-Seq and RRBS for DNA methylation and ChIP-Seq for histone modification in the field of stem cell. The potential contribution of epigenetic modifications to tumorigenesis is also described. At present, the epigenome research still faces the defects of current sampling strategy and unknown network regulation pattern. In future, worldwide collaboration and latest sequencing technologies application are expected to solve these problem and offer new insight into epigenome research.

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Epigenetic Control Systems

Cited by 319 publications

References 6 publications

Transgenerational Epigenetic Inheritance: Prevalence, Mechanisms, and Implications for the Study of Heredity and Evolution

Transgenerational Epigenetic Inheritance: Prevalence, Mechanisms, and Implications for the Study of Heredity and Evolution

Chronic kidney disease in children and the role of epigenetics: Future therapeutic trajectories

The Contribution of Next Generation Sequencing Technologies to Epigenome Research of Stem Cell and Tumorigenesis

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