Epigenetic Genome Modifications during Pregnancy: The Impact of Essential Nutritional Supplements on DNA Methylation

Socha, Maciej W.; Flis, Wojciech; Wartęga, Mateusz

doi:10.3390/nu16050678

Cited by 5 publications

(1 citation statement)

References 202 publications

(309 reference statements)

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“…Secondly, folic acid directly contributes to fetal development and growth, thereby promoting higher GWG [ 45 ]. For instance, folic acid is involved in energy and protein metabolism, as well as in the synthesis of deoxyribonucleic acid (DNA), ribonucleic acid (RNA), and cell division [ 46 ]. Folic acid deficiency has been linked to adverse pregnancy outcomes, including low birth weight and preterm birth [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

Serum Folate, Red Blood Cell Folate, and Zinc Serum Levels Are Related with Gestational Weight Gain and Offspring’s Birth-Weight of Adolescent Mothers

Sámano,

Martínez-Rojano,

Chico-Barba

et al. 2024

Nutrients

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Background: Gestational weight gain below or above the Institute of Medicine recommendations has been associated with adverse perinatal and neonatal outcomes. Very few studies have evaluated the association between serum and red blood cell folate concentrations and gestational weight gain in adolescents. Additionally, zinc deficiency during pregnancy has been associated with impaired immunity, prolonged labor, preterm and post-term birth, intrauterine growth restriction, low birth weight, and pregnancy-induced hypertension. Objective: The purpose of our study is to evaluate the association between serum concentrations of zinc, serum folate, and red blood cell folate, with the increase in gestational weight and the weight and length of the newborn in a group of adolescent mothers from Mexico City. Results: In our study, 406 adolescent-neonate dyads participated. The adolescents’ median age was 15.8 years old. The predominant socioeconomic level was middle-low (57.8%), single (57%), 89.9% were engaged in home activities, and 41.3% completed secondary education. Excessive gestational weight gain was observed in 36.7% of cases, while insufficient gestational weight gain was noted in 38.4%. Small for gestational age infants were observed in 20.9% of the sample. Low serum folate (OR 2.1, 95% CI 1.3–3.3), decreased red blood cell folate (OR 1.6, 95% CI 1.0–2.6), and reduced serum zinc concentrations (OR 3.3, 95% CI 2.1–5.2) were associated with insufficient gestational weight gain. Decreased serum zinc levels (OR 1.2, 95% CI 1.2–3.4) were linked to an increased probability of delivering a baby who is small for their gestational age. Conclusions: Low serum folate, red blood cell folate, and serum zinc concentrations were associated with gestational weight gain and having a small gestational age baby. Both excessive and insufficient gestational weight gain, as well as having a small gestational age baby, are frequent among adolescent mothers.

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Section: Discussionmentioning

confidence: 99%

Serum Folate, Red Blood Cell Folate, and Zinc Serum Levels Are Related with Gestational Weight Gain and Offspring’s Birth-Weight of Adolescent Mothers

Sámano,

Martínez-Rojano,

Chico-Barba

et al. 2024

Nutrients

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The causal relationship between hydatidiform mole and nutrients: A two-sample Mendelian randomization study

Zhu,

Jiang

et al. 2024

Clinical Nutrition ESPEN

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Cardiovascular Health Starts in the Womb

Falkner,

Alexander,

Nuyt

et al. 2024

Hypertension

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Hypertension has largely been viewed as a disorder of adulthood. Historically, blood pressure (BP) was not routinely measured in children because hypertension was considered uncommon in childhood. It was not until the 1970s that it was apparent that in childhood BP levels were normally lower compared with those in adults, were related to age and growth, and that abnormal BP in children needed different definitions. Based on the distribution of BP levels in available child cohorts, the 95th percentile of BP levels became the definition of hypertension in children and adolescents—an epidemiological definition. Subsequent clinical and epidemiological research identified associated risk factors in childhood that linked abnormal BP in youth with hypertension in adulthood. In the 1980s, the Barker hypothesis, based on observations that low birth weight could be linked to cardiovascular disease in adulthood, promoted further research spanning epidemiological, clinical, and basic science on the childhood origins of hypertension. This review focuses on recent findings from both longitudinal maternal-child cohorts and experimental models that examine both maternal and offspring conditions associated with risks of subsequent cardiovascular disease.

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Epigenetic Genome Modifications during Pregnancy: The Impact of Essential Nutritional Supplements on DNA Methylation

Cited by 5 publications

References 202 publications

Serum Folate, Red Blood Cell Folate, and Zinc Serum Levels Are Related with Gestational Weight Gain and Offspring’s Birth-Weight of Adolescent Mothers

Serum Folate, Red Blood Cell Folate, and Zinc Serum Levels Are Related with Gestational Weight Gain and Offspring’s Birth-Weight of Adolescent Mothers

The causal relationship between hydatidiform mole and nutrients: A two-sample Mendelian randomization study

Cardiovascular Health Starts in the Womb

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