Epigenetic Inheritance and the Moral Responsibilities of Mothers

doi:10.1001/virtualmentor.2013.15.9.stas1-1309

Cited by 5 publications

(1 citation statement)

References 10 publications

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“…In understanding the concept of personalized medicine there are multiple possible interpretations of 'personalization' at stake. This is important because the terms used to describe the type of medical interventions on offer may seem to promise much, and they have consequences for the expectations of patients, clients and society (see, e.g., Hedgecoe 2004;Tutton 2014;Wöhlke et al 2015). It should of course be noted that while there have been and continue to be attempts to provide definitions of personalized medicine, there have also been moves to go beyond the term 'personalized' to use others such as 'precision' medicine.…”

Section: -Introductionmentioning

confidence: 99%

What’s in a name: conceptions of personalized medicine and their ethical implications

Chadwick

2017

Lato Sensu

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So what effect does it have on expectations to describe the new era of medicine as 'personalized'? There is some em-Medicine is said to be moving rapidly down the road towards personalization, but it is not entirely clear how we are to understand this term, or its implications for ethics. In understanding the concept of personalized medicine there are multiple possible interpretations of 'personalization' at stake. These may in turn presuppose different concepts of 'person', with resulting variations in the ethical implications. Sommaire 1-Introduction 2-Why is it important to elucidate different meanings of 'personalized'? 3-Senses of personalization 4-Combination of different senses? 5-Conclusion

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Section: -Introductionmentioning

confidence: 99%

What’s in a name: conceptions of personalized medicine and their ethical implications

Chadwick

2017

Lato Sensu

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Maternal epigenetic responsibility: what can we learn from the pandemic?

Turkmendag

Liaw

2022

Med Health Care and Philos

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This paper examines the construction of maternal responsibility in transgenerational epigenetics and its implications for pregnant women. Transgenerational epigenetics is suggesting a link between maternal behaviour and lifestyle during pregnancy and the subsequent well-being of their children. For example, poor prenatal diet and exposure to maternal distress during pregnancy are linked to epigenetic changes, which may cause health problems in the offspring. In this field, the uterus is seen as a micro-environment in which new generations can take shape. Because epigenetics concerns how gene expression is influenced by the social realm, including a range of environmental conditions such as stress, diet, smoking, exercise, exposure to chemicals, pollution, and environmental hazards, the research findings in this area have direct policy relevance. For policy makers, rather than controlling this complex range of determinants of health, isolating and targeting maternal body and responsibilising mothers for the control of this micro-environment might seem feasible. Yet, examining the maternal body in isolation as a powerful environment to shape the health of next generations not only responsibilises women for the environment that they cannot control but also makes them a target for intrusive and potentially exploitative biomedical interventions. Even though ‘social factors’ are increasingly considered in epigenetics writing, the phrase is usually taken as self-explanatory without much elaboration. Drawing on the Covid-19 pandemic, this paper moves the current debate forward by providing consolidated examples of how individuals, including pregnant women, have little control over their environment and lifestyle. As evidenced by the pandemic’s disproportionate effects on people with low socioeconomic or poor health status, some pregnant women bore considerable physical and psychological stress which combined with other stress factors such as domestic violence.

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The ethical aspects of exposome research: a systematic review

et al. 2023

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In recent years, exposome research has been put forward as the next frontier for the study of human health and disease. Exposome research entails the analysis of the totality of environmental exposures and their corresponding biological responses within the human body. Increasingly, this is operationalized by big-data approaches to map the effects of internal as well as external exposures using smart sensors and multi-omics technologies. However, the ethical implications of exposome research are still only rarely discussed in the literature. Therefore, we conducted a systematic review of the academic literature regarding both the exposome and underlying research fields and approaches, to map the ethical aspects that are relevant to exposome research. We identify five ethical themes that are prominent in ethics discussions: the goals of exposome research, its standards, its tools, how it relates to study participants and the consequences of its products. Furthermore, we provide a number of general principles for how future ethics research can best make use of our comprehensive overview of the ethical aspects of exposome research. Lastly, we highlight three aspects of exposome research that are most in need of ethical reflection: the actionability of its findings, the epidemiological or clinical norms applicable to exposome research and the meaning and action-implications of bias.

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Epigenetic Inheritance and the Moral Responsibilities of Mothers

Cited by 5 publications

References 10 publications

What’s in a name: conceptions of personalized medicine and their ethical implications

What’s in a name: conceptions of personalized medicine and their ethical implications

Maternal epigenetic responsibility: what can we learn from the pandemic?

The ethical aspects of exposome research: a systematic review

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