Epigenetic Modifications Associated with Exposure to Endocrine Disrupting Chemicals in Patients with Gestational Diabetes Mellitus

Kunysz, Mateusz; Mora-Janiszewska, Olimpia; Darmochwał-Kolarz, Dorota

doi:10.3390/ijms22094693

Cited by 22 publications

(8 citation statements)

References 137 publications

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“…diet, obesity, smoking, hormone supplementation) [ 14 , 29 , 30 ] and the environment (e.g. exposure to endocrine disruptors) [ 31 ] to which the patient has been or is exposed. To the extent that the lifestyle could be inferred from the epigenetic state, a change in the principle of autonomy can occur.…”

Section: Ethical Implications Of Epigenetic-predictive Biomarkersmentioning

confidence: 99%

Ethical implications of epigenetics in the era of personalized medicine

Santaló

Berdasco

2022

Clin Epigenet

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Given the increasing research activity on epigenetics to monitor human diseases and its connection with lifestyle and environmental expositions, the field of epigenetics has attracted a great deal of interest also at the ethical and societal level. In this review, we will identify and discuss current ethical, legal and social issues of epigenetics research in the context of personalized medicine. The review covers ethical aspects such as how epigenetic information should impact patient autonomy and the ability to generate an intentional and voluntary decision, the measures of data protection related to privacy and confidentiality derived from epigenome studies (e.g., risk of discrimination, patient re-identification and unexpected findings) or the debate in the distribution of responsibilities for health (i.e., personal versus public responsibilities). We pay special attention to the risk of social discrimination and stigmatization as a consequence of inferring information related to lifestyle and environmental exposures potentially contained in epigenetic data. Furthermore, as exposures to the environment and individual habits do not affect all populations equally, the violation of the principle of distributive justice in the access to the benefits of clinical epigenetics is discussed. In this regard, epigenetics represents a great opportunity for the integration of public policy measures aimed to create healthier living environments. Whether these public policies will coexist or, in contrast, compete with strategies reinforcing the personalized medicine interventions needs to be considered. The review ends with a reflection on the main challenges in epigenetic research, some of them in a technical dimension (e.g., assessing causality or establishing reference epigenomes) but also in the ethical and social sphere (e.g., risk to add an epigenetic determinism on top of the current genetic one). In sum, integration into life science investigation of social experiences such as exposure to risk, nutritional habits, prejudice and stigma, is imperative to understand epigenetic variation in disease. This pragmatic approach is required to locate clinical epigenetics out of the experimental laboratories and facilitate its implementation into society.

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Section: Ethical Implications Of Epigenetic-predictive Biomarkersmentioning

confidence: 99%

Ethical implications of epigenetics in the era of personalized medicine

Santaló

Berdasco

2022

Clin Epigenet

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“…Gestational diabetes mellitus (GDM) is a type of diabetes that is first diagnosed during pregnancy, with increasing incidence in recent decades. GDM is associated with increased risks of serious adverse pregnancy outcomes and birth outcomes, including preeclampsia and spontaneous abortion, maternal metabolic syndrome, fetal anomalies, neonatal hypoglycemia, and newborn asphyxia . Epidemiologic evidence has demonstrated that exposure to heavy metals, industrial organic pollutants, and pesticides is an environmental risk factor for GDM. − Although urinary 3-PBA has been frequently detected in pregnant populations from different regions, − whether exposure to pyrethroids contributes to the development of GDM remains unknown.…”

Section: Introductionmentioning

confidence: 99%

First Evidence of the Associations of Exposure to Pyrethroid Insecticides with the Risk of Gestational Diabetes Mellitus

Ma,

Song,

et al. 2024

Environ. Sci. Technol. Lett.

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Pyrethroids, a class of extensively used insecticides, may pose health risks to humans. Whether pyrethroid exposure contributes to the development of gestational diabetes mellitus (GDM) in pregnant women remains unknown. The potential association of urinary concentrations of pyrethroid metabolites [3-phenoxybenzoic acid (3-PBA) and 4-fluoro-3-phenoxybenzoic acid] with the risk of GDM was assessed using a nested case-control study of 220 GDM cases and 440 controls from a prospective cohort. The mediation roles of oxidative stress biomarkers [advanced glycation end products (AGEs) and malondialdehyde (MDA)] in the associations were investigated. Urinary concentrations of 3-PBA in these cases were significantly higher than those of the controls. Urinary 3-PBA was positively associated with the risk of GDM. The adjusted odds of GDM significantly increased by 32% in each unit increment of the ln-transformed concentration of urinary 3-PBA. The significant dose−response relationships of GDM with serum AGEs (P trend = 0.03) and MDA (P trend < 0.001) were observed. However, there were no significant correlations between 3-PBA and AGEs or MDA, nor was there a significant mediation effect of AGEs or MDA on the association of 3-PBA with GDM. We provide the first evidence that early gestational exposure to pyrethroids is an environmental risk factor for GDM.

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“…Epigenetic regulation has a crucial potential in the pathogenesis of GDM. 8 The epigenetic regulation contains histone modification, DNA methylation along with microRNA (miRNA) depletion, which are strongly associated with each other and affect protein synthesis patterns. 9 MiRNAs belong to highly conserved small noncoding RNAs and affect the progression of diseases via post-transcriptionally modulating gene expression.…”

Section: Introductionmentioning

confidence: 99%

Correlation between serum microRNA-122 and VEGF expression and pregnancy outcome in gestational diabetes mellitus patients

He,

Wang,

Wang

et al. 2023

Pak J Med Sci

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Objective: Gestational diabetes mellitus (GDM) seriously influences the health of mothers and babies, and there are still no effective early diagnostic markers. Therefore, our study planned to probe the correlation between serum microRNA-122 and VEGF expression and pregnancy outcome in GDM patients. Methods: This was a retrospective study of the correlation between serum microRNA-122 and vascular endothelial growth factor (VEGF) expression and pregnancy outcome in GDM patients. Sixty GDM patients admitted to the Fourth Hospital of Shijiazhuang from January 2021 to October 2022 were included in the research group (RG), and another 60 healthy pregnant women were included in the control group (CG). Serum miR-122 and VEGF levels were quantified using quantitative real-time polymerase chain reaction. The value of miR-122 and VEGF in predicting adverse pregnancy outcomes was analyzed by receiver operating characteristic curve. Results: Serum miR-122 and VEGF levels in the RG were higher relative to the CG. The total occurrence of adverse pregnancy outcomes in the RG was higher relative to the CG (P<0.05). Serum miR-122 together with VEGF levels in the poor outcome group was higher relative to the good outcome group (P<0.05). ROC analysis revealed that miR-122 and VEGF could be used to predict adverse pregnancy outcome (P<0.0001). The area under the curve of miR-122 was 0.860, 95% confidence interval (CI) =0.793-0.926, and the area under the curve of VEGF was 0.780, 95% CI =0.694-0.866. Serum levels of miR-122, VEGF were positively related with abortion, preterm delivery, low birth weight infants, macrogenesis infants, and fetal development abnormalities (P<0.001). Conclusion: The higher serum miR-122 and VEGF levels in GDM patients with satisfactory blood glucose control, the greater the probability of adverse pregnancy outcome, which should be paid attention to by clinicians. doi: https://doi.org/10.12669/pjms.40.3.8467 How to cite this: He H, Wang Y, Wang H, Ma Y, Zhang P. Correlation between serum microRNA-122 and VEGF expression and pregnancy outcome in gestational diabetes mellitus patients. Pak J Med Sci. 2024;40(3):---------. doi: https://doi.org/10.12669/pjms.40.3.8467 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Epigenetic Modifications Associated with Exposure to Endocrine Disrupting Chemicals in Patients with Gestational Diabetes Mellitus

Cited by 22 publications

References 137 publications

Ethical implications of epigenetics in the era of personalized medicine

Ethical implications of epigenetics in the era of personalized medicine

First Evidence of the Associations of Exposure to Pyrethroid Insecticides with the Risk of Gestational Diabetes Mellitus

Correlation between serum microRNA-122 and VEGF expression and pregnancy outcome in gestational diabetes mellitus patients

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