Epigenetic modifications in the development of bronchopulmonary dysplasia: a review

Epigenetics and bronchopulmonary dysplasia: unraveling the complex interplay and potential therapeutic implications

“…20,21 In addition, miR mimics and inhibitors are potential strategies for modulating gene expression and improving the pulmonary pathology in BPD. 22,23 In their paper, Wang et al 24 do a comprehensive review of DNA methylation, histone modifications, miRs, lncRNAs, and circular (circ)RNAs role in BPD. They discuss the different sources (lung tissue from mice in experimental BPD models, and cord blood as well as buccal samples from human preterm infants) that have been used to detect the epigenetic changes.…”

“…Most of the data generated, as reported in the review by Wang et al 24 , have been generated using animal models. So, while such preclinical findings are promising, translating them into clinical practice remains challenging.…”