Epigenetic modulation, stress and plasticity in susceptibility of the snail host, Biomphalaria glabrata, to Schistosoma mansoni infection

Knight, Matty; Ittiprasert, Wannaporn; Arican-Goktas, Halime D.; Bridger, Joanna M.

doi:10.1016/j.ijpara.2016.03.003

Cited by 31 publications

(24 citation statements)

References 41 publications

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“…However, the infection only occurred at the higher miracidial doses in B. tenagophila (SJC), indicating that this species is less susceptible to E. paraensei infection. These results are in accordance to Knight et al (2016), who proposed that the parasite may orchestrate the behavior of speciic genes, speciically HSP 70, to its advantage. In general, the number of miracidia used are a determining factor for infectivity.…”

Section: Discussionsupporting

confidence: 92%

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Assessment of the experimental infection by Echinostoma paraensei (Lie & Basch, 1967) (Trematoda: Echinostomatidae) in two Biomphalaria tenagophila (D’Orbigny, 1835) (Gastropoda: Planorbidae) isolates resistant and susceptible to Schistosoma mansoni (Sambon, 1907) (Trematoda: Schistosomatidae)

et al. 2017

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Resumo Avaliação da infecção experimental por AbstractDifferent isolates of Biomphalaria tenagophila show a large spectrum of compatibility to the trematode Schistosoma mansoni, ranging from entirely refractory to highly susceptible. The aim of this study was to verify the pattern of compatibility of two B. tenagophila geographical isolates, resistant and susceptible to S. mansoni, when infected with Echinostoma paraensei. The snails were exposed to different numbers of miracidia, and mortality, histopathological characteristics and the number of cercariae released were evaluated. A correlation between the number of miracidia and the infectivity rate of B. tenagophila (TAIM) was observed. There was no correlation between the number of miracidia used and the number of cercariae released for both B. tenagophila isolates. Biomphalaria tenagophila (SJC) showed little susceptibility to the E. paraensei infection. The results demonstrate different degrees of compatibility for the two B. tenagophila isolates when infected with E. paraensei, and may contribute to studies about host-parasite relationships.

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Section: Discussionsupporting

confidence: 92%

“…The changes provoked by these mechanisms, such as stress, result in a selective pressure that shapes parasite survival or destruction in the host (ITTIPRASERT; KNIGHT, 2012;KNIGHT et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Assessment of the experimental infection by Echinostoma paraensei (Lie & Basch, 1967) (Trematoda: Echinostomatidae) in two Biomphalaria tenagophila (D’Orbigny, 1835) (Gastropoda: Planorbidae) isolates resistant and susceptible to Schistosoma mansoni (Sambon, 1907) (Trematoda: Schistosomatidae)

et al. 2017

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“…Populations with phenotypic differences in susceptibility to infection by certain trematode species have also been described within the same species [33]. The susceptibility has been shown to be associated with expression of certain stress genes, in the case of the snail Biomphalaria glabrata and the parasite trematode Schistosoma mansoni [34, 35]. Finally, the findings of the present study confirm the rarity of natural co-infections with different digenean species [20, 21, 36], probably as a result of competition, which would play an important role in the configuration of trematode infection status of snail populations in each habitat.…”

Section: Discussionmentioning

confidence: 99%

Transmission of Calicophoron daubneyi and Fasciola hepatica in Galicia (Spain): Temporal follow-up in the intermediate and definitive hosts

et al. 2016

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BackgroundParamphistomosis caused by Calicophoron daubneyi and fasciolosis caused by Fasciola hepatica are common parasitic diseases of livestock animals. Transmission of the diseases depends on the presence of intermediate hosts, i.e. freshwater gastropods such as lymnaeids. We carried out a 2-year-long study of the dynamics of the snail population acting as the intermediate host for these parasites, considering the population structure in terms of size/age and infection status. In addition, we determined the kinetics of trematode egg excretion in grazing cows. Generalized Additive Models (GAMs) were used to analyze the associations between different response variables and snail size, sampling month and weather-related variables.ResultsOf the molluscan species examined, Galba truncatula, Radix peregra, Anisus (Anisus) leucostoma and Pisidium casertanum (n = 2802), only G. truncatula was infected with C. daubneyi or F. hepatica, at prevalence rates of 8.2% and 4.4% respectively. The probability of infection with C. daubneyi or F. hepatica was linearly related to snail size, although in different ways (negative for C. daubneyi and positive for F. hepatica). The total snail population increased in winter, when specimens of all size classes were found. Infected snails were more abundant during spring-autumn. Mature cercariae of both parasites were found in most seasons. In the statistical models, the sampling month accounted for a high percentage (71.9–78.2%) of the observed variability in snail abundance. The inclusion of climatic variables in the models moderately increased the percentage of deviance explained (77.7–91.9%). Excretion of C. daubneyi eggs in cow faeces was always higher than that of F. hepatica eggs.ConclusionsParticular care should be taken to prevent pastures and the surrounding environment being contaminated with parasite eggs during winter-spring, when the number of snails susceptible to miracidial infections is maximal. This is therefore the optimal time for treating grazing animals. Nevertheless, control of trematodosis based only on chemotherapy is difficult in an area such as the study area, where environmental factors favour the regular appearance of snail populations harbouring mature cercariae.Electronic supplementary materialThe online version of this article (doi:10.1186/s13071-016-1892-8) contains supplementary material, which is available to authorized users.

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“…Insertion of TEs into promoter of hsp s can change hsp expression and, in turn, variations in stress tolerance, fecundity and development (Chen & Wagner, ; Chen et al., ; Lerman & Feder, ). Such phenotypic changes may result in selection on the underlying TE (Chen et al., ). Epigenetic variation such as methylation clearly may affect hsp expression, but its role in evolutionary adaptation is as yet unclear (Knight, Ittiprasert, Arican‐Goktas, & Bridger, ; Meyer et al., ; Norouzitallab et al., ; Tetievsky et al., ; Venney, Johansson, & Heath, ; Weyrich et al., ). Still to be resolved is the persistence of epigenetic variants of hsp s in evolutionary time (Chen et al., ).…”

Section: Relevance To Evolutionary Adaptationmentioning

confidence: 99%

Evolution of heat‐shock protein expression underlying adaptive responses to environmental stress

2018

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Heat-shock proteins (Hsps) and their cognates are primary mitigators of cell stress. With increasingly severe impacts of climate change and other human modifications of the biosphere, the ability of the heat-shock system to affect evolutionary fitness in environments outside the laboratory and to evolve in response is topic of growing importance. Since the last major reviews, several advances have occurred. First, demonstrations of the heat-shock response outside the laboratory now include many additional taxa and environments. Many of these demonstrations are only correlative, however. More importantly, technical advances in "omic" quantification of nucleic acids and proteins, genomewide association analysis, and manipulation of genes and their expression have enabled the field to move beyond correlation. Several consequent advances are already evident: The pathway from heat-shock gene expression to stress tolerance in nature can be extremely complex, mediated through multiple biological processes and systems, and even multiple species. The underlying genes are more numerous, diverse and variable than previously appreciated, especially with respect to their regulatory variation and epigenetic changes. The impacts and limitations (e.g., due to trade-offs) of natural selection on these genes have become more obvious and better established. At last, as evolutionary capacitors, Hsps may have distinctive impacts on the evolution of other genes and ecological consequences.

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Epigenetic modulation, stress and plasticity in susceptibility of the snail host, Biomphalaria glabrata, to Schistosoma mansoni infection

Cited by 31 publications

References 41 publications

Assessment of the experimental infection by Echinostoma paraensei (Lie & Basch, 1967) (Trematoda: Echinostomatidae) in two Biomphalaria tenagophila (D’Orbigny, 1835) (Gastropoda: Planorbidae) isolates resistant and susceptible to Schistosoma mansoni (Sambon, 1907) (Trematoda: Schistosomatidae)

Assessment of the experimental infection by Echinostoma paraensei (Lie & Basch, 1967) (Trematoda: Echinostomatidae) in two Biomphalaria tenagophila (D’Orbigny, 1835) (Gastropoda: Planorbidae) isolates resistant and susceptible to Schistosoma mansoni (Sambon, 1907) (Trematoda: Schistosomatidae)

Transmission of Calicophoron daubneyi and Fasciola hepatica in Galicia (Spain): Temporal follow-up in the intermediate and definitive hosts

Evolution of heat‐shock protein expression underlying adaptive responses to environmental stress

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