Epigenetics and Cutaneous Neoplasms: From Mechanism to Therapy

Gibson, Frederick T; Hanly, Ailish; Fisher, Robert; Wyant, W. Austin; Wu, Muzhou; Collard, Marianne; Alani, Rhoda M.

doi:10.2217/epi-2023-0016

Cited by 3 publications

(1 citation statement)

References 202 publications

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“…One key focus of RNA methylation research is m6A, which regulates gene expression and plays a role in subsequent biological processes such as mRNA stability, transcription, and translation 7 , 8 . Abnormal regulation of RNA methylation has been associated with the development of tumors and age-related neurological diseases such as Alzheimer's disease 9 , Parkinson's disease 10 , and depression. Overall, epigenetics is a fascinating area of biology that is helping to illuminate the intricate ways that our genes are regulated and controlled.…”

Section: Introductionmentioning

confidence: 99%

A comprehensive epigenetic network can influence the occurrence of thyroid-associated ophthalmopathy by affecting immune and inflammatory response

Zhang,

Wu,

Gong

et al. 2024

Sci Rep

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The primary objective of this study is to understand the regulatory role of epigenetics in thyroid-associated ophthalmopathy (TAO) using multi-omics sequencing data. We utilized tRFs sequencing data, DNA methylation sequencing data, and lncRNA/circRNA/mRNA sequencing data, as well as several RNA methylation target prediction websites, to analyze the regulatory effect of DNA methylation, non-coding RNA, and RNA methylation on TAO-associated genes. Through differential expression analysis, we identified 1019 differentially expressed genes, 985 differentially methylated genes, and 2601 non-coding RNA. Functional analysis showed that differentially expressed genes were mostly associated with the PI3K signaling pathway and the IL17 signaling pathway. Genes regulated by DNA epigenetic regulatory networks were mainly related to the Cytokine-cytokine receptor interaction pathway, whereas genes regulated by RNA epigenetic regulatory networks were primarily related to the T cell receptor signaling pathway. Finally, our integrated regulatory network analysis revealed that epigenetics mainly impacts the occurrence of TAO through its effects on key pathways such as cell killing, cytokine production, and immune response. In summary, this study is the first to reveal a new mechanism underlying the development of TAO and provides new directions for future TAO research.

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Section: Introductionmentioning

confidence: 99%

A comprehensive epigenetic network can influence the occurrence of thyroid-associated ophthalmopathy by affecting immune and inflammatory response

Zhang,

Wu,

Gong

et al. 2024

Sci Rep

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Targeting epitranscriptomics for novel drug development

Vemulapalli

2024

Biochemical and Molecular Pharmacology in Drug Discovery

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Epigenetics of Conjunctival Melanoma: Current Knowledge and Future Directions

Flick,

Demirci,

Demirci

2024

Cancers

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The purpose of this article is to provide a literature review of the epigenetic understanding of conjunctival melanoma (CM), with a primary focus on current gaps in knowledge and future directions in research. CM is a rare aggressive cancer that predominantly affects older adults. Local recurrences and distant metastases commonly occur in CM patients; however, their prediction and management remain challenging. Hence, there is currently an unmet need for useful biomarkers and more effective treatments to improve the clinical outcomes of these patients. Like other cancers, CM occurrence and prognosis are believed to be influenced by multiple genetic and epigenetic factors that contribute to tumor development/progression/recurrence/spread, immune evasion, and primary/acquired resistance to therapies. Epigenetic alterations may involve changes in chromatin conformation/accessibility, post-translational histone modifications or the use of histone variants, changes in DNA methylation, alterations in levels/functions of short (small) or long non-coding RNAs (ncRNAs), or RNA modifications. While recent years have witnessed a rapid increase in available epigenetic technologies and epigenetic modulation-based treatment options, which has enabled the development/implementation of various epi-drugs in the cancer field, the epigenetic understanding of CM remains limited due to a relatively small number of epigenetic studies published to date. These studies primarily investigated DNA methylation, ncRNA (e.g., miRNA or circRNA) expression, or RNA methylation. While these initial epigenetic investigations have revealed some potential biomarkers and/or therapeutic targets, they had various limitations, and their findings warrant replication in independent and larger studies/samples. In summary, an in-depth understanding of CM epigenetics remains largely incomplete but essential for advancing our molecular knowledge and improving clinical management/outcomes of this aggressive disease.

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Epigenetics and Cutaneous Neoplasms: From Mechanism to Therapy

Cited by 3 publications

References 202 publications

A comprehensive epigenetic network can influence the occurrence of thyroid-associated ophthalmopathy by affecting immune and inflammatory response

A comprehensive epigenetic network can influence the occurrence of thyroid-associated ophthalmopathy by affecting immune and inflammatory response

Targeting epitranscriptomics for novel drug development

Epigenetics of Conjunctival Melanoma: Current Knowledge and Future Directions

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