2021
DOI: 10.21203/rs.3.rs-167499/v1
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Epigenome-wide association study of level and change in cognitive abilities from midlife through late-life

Abstract: Background: Epigenetic mechanisms are important in aging and may be involved in late-life changes in cognitive abilities. We conducted an epigenome-wide association study of leukocyte DNA methylation in relation to level and change in cognitive abilities, from midlife through late-life in 535 Swedish twins. Results: Methylation levels were measured with the Infinium Human Methylation 450K or Infinium MethylationEpic array, and all sites passing quality control on both arrays were selected for analysis (n=250 8… Show more

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