Epilepsy and Anxiety

Goldstein, Martin; Harden, Cynthia L.

doi:10.1006/ebeh.2000.0080

Cited by 71 publications

(24 citation statements)

References 21 publications

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“…In the case of children and adolescents, most of the literature supports a direct relationship between increased seizure frequency and anxiety disorders (Williams et al, 2003;Ettinger et al, 1998;Kessler et al 2001;Oguz et al 2002;Alwash et al, 2000;Adeewuya et al, 2005). In adults, the risk of anxiety disorders appears to be higher in focal (especially temporal lobe) than in generalized epilepsies (Garcia Morales et al, 2008;Goldstein & Harden, 2000;Vasquez & Devinsky 2003;Marsh & Rao, 2002, Piazzini et al, 2001. Anxiety disorders were found to be linked with the seizures originated from left temporal lobe but this is not entirely consistent in the literature (Andelman et al, 2001).…”

Section: Epilepsy Related Factorsmentioning

confidence: 98%

Anxiety Disorders in Epilepsy

Ekinci¹

2011

Anxiety and Related Disorders

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Section: Epilepsy Related Factorsmentioning

confidence: 98%

Anxiety Disorders in Epilepsy

Ekinci¹

2011

Anxiety and Related Disorders

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“…limbische Strukturen am Anfallsgeschehen beteiligt sind [10,14]. Mindestens 20% der Patienten mit Temporallappenepilepsie zeigen iktale Ängste und Panikattacken [4].…”

Section: Angst Als Iktales Phänomenunclassified

“…Einige Autoren [10] betonen, dass iktale Ängste Ausprägungen von Angststö-rungen (beispielsweise Panikstörung) annehmen können und nur sehr schwer von diesen zu differenzieren sind. Nur eine genaue klinische Abklärung (z.…”

Section: Angst Als Iktales Phänomenunclassified

Angststörungen und Epilepsie

Maragkos

Demarle-Meusel²,

Ortenburger

et al. 2009

Z. Epileptol.

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“…Regardless, this leaves anxiety as common epileptic comorbidity under further investigation with severe effects that deserve a proper attention. Some of them include the panic attacks, social isolation, phobias, increase rate of paranoid behavior, generalized anxiety, worsening the quality of life, and finally, the increase in suicide rate (6)(7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

“…The highly exploratory nature of many strains of inbred rats provides a model system for exploiting innate behavioral tendencies which appear to be released or inhibited by a variety of compounds. The theoretical basis of the anxiety or anxiolytic effects lie in a (dis)inhibition of some fearful response to a strange or aversive environment, decreasing or enhancing the natural tendency of rats to explore any new habitat (8,9). Therefore, one of the signs of the anxiety-related behavior in rodents can be the alteration in the exploratory behavior.…”

Section: Introductionmentioning

confidence: 99%

Exploratory behavior alteration as an epileptic comorbidity in elevated plus maze test

Ademovič¹,

Lekovic²,

Knežević³

et al. 2017

Med podmladak

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Introduction: Epileptic seizure consists of preictal, ictal and postictal period. Postictal period is characterized by a variety of psychiatric phenomenon of which the most frequent ones are anxiety and depressive disorder. Anxiety in rodents can be assessed by measuring the exploratory behavior. Lindane evokes generalized tonic-clonic epileptic seizures in rats, when applied intraperitoneally, due to its lypophilic characteristics. Aim: The aim of this study was to assess exploratory behavior linked with anxiety level in the elevated plus maze test (EPM) upon generalized seizures, induced by lindane in male rats. Material and methods: The experiment was conducted on Wistar albino male rats that were randomly divided into: control group (DMSO, 0.5 ml/kg) and experimental group (lindane, 8 mg/kg) (n=8, each). After the drug injection, the assessment of the seizure intensity lasted for 30 minutes. Descriptive rating scale was used to describe the seizure severity. Subsequently, the EPM testing took place immediately after evoking the seizure (Test 1), after 1h (Test 2) and after 24h (Test 3). Time spent in open areas and number of transitions was further analyzed. Results: Experimental group of animals spent less time in open areas of EPM, when compared to controls in Test 1 and Test 2. The same holds true for the number of transitions to the open area, i.e. lindane-treated animals tend to stay in enclosed parts of the maze in Test1, Test 2. Finally, in Test 3 there was no significant difference between the groups, in any parameter of interest. Conclusion: Lindane-induced generalized epileptic seizures are accompanied by reduced exploratory behavior in the elevated plus maze test, up to 24h after the seizure ended. This finding can be a basis for the further translational research of anxiety as epileptic comorbidity in this experimental model of epilepsy.

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Epilepsy and Anxiety

Cited by 71 publications

References 21 publications

Anxiety Disorders in Epilepsy

Anxiety Disorders in Epilepsy

Angststörungen und Epilepsie

Exploratory behavior alteration as an epileptic comorbidity in elevated plus maze test

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