Epileptogenic high-frequency oscillations skip the motor area in children with multilobar drug-resistant epilepsy

Iimura, Yasushi; Jones, Kay S.; Hattori, Kyoko; Okazawa, Yushi; Noda, Atsuko; Hoashi, Kana; Nonoda, Yutaka; Asano, Eishi; Akiyama, Tomoyuki; Go, Cristina; Ochi, Ayako; Snead, O. Carter; Donner, Elizabeth; Rutka, James T.; Drake, James M.; Otsubo, Hiroshi

doi:10.1016/j.clinph.2017.03.031

Cited by 29 publications

(39 citation statements)

References 49 publications

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“…2 The underlying mechanism for the generation of ES is not yet known. [4][5][6][7] Barba et al reported 58 patients with ES who underwent unilobar resection and 22 patients with ES who underwent multilobar resection. 3 The cessation of drug-resistant ES after multilobar resection including subtotal hemispherectomy indicates that one of the mechanisms of ES is the focal onset seizure of cortical origin.…”

Section: Epileptic Spasmsmentioning

confidence: 99%

Strong coupling between slow oscillations and wide fast ripples in children with epileptic spasms: Investigation of modulation index and occurrence rate

et al. 2018

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Section: Epileptic Spasmsmentioning

confidence: 99%

Strong coupling between slow oscillations and wide fast ripples in children with epileptic spasms: Investigation of modulation index and occurrence rate

et al. 2018

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“…Regions showing a high rate of interictal HFOs have been correlated with pathological epileptic tissue in different studies [2,15,48,52–54]. The rate of HFOs (through various frequency bands) was shown to be higher inside the seizure onset zone (SOZ) than outside (NSOZ) [45,47–49,51,52]. This is supported by studies using different approaches in defining the pHFOs and nHFOs, e.g.…”

Section: Hfos Rate Amplitude and Durationmentioning

confidence: 84%

“…Regional differences in the behavior and nature of HFOs have also been reported in human studies, particularly in mesial temporal, motor and occipital structures [15,45,51,55,56,59,65]. …”

Section: Anatomical Location Of Hfosmentioning

confidence: 91%

“…While early studies were focused on the frequency band of the HFOs oscillations to classify them as pathologic or physiologic, considering the wide range of overlapping pHFOs and nHFOs frequencies [3,4,11,18,42–44], more recent studies have explored other frequency-independent characteristics of HFOs: rate, amplitude, and duration [45–52]. Regions showing a high rate of interictal HFOs have been correlated with pathological epileptic tissue in different studies [2,15,48,52–54].…”

Section: Hfos Rate Amplitude and Durationmentioning

confidence: 99%

“…considering task-induced HFOs as nHFOs [15,55], or HFOs associated with interictal epileptiform discharges (IEDs) as pHFOs [21,56]. Also, resection of the high-rate HFOs regions was found to be correlated with favorable surgery outcome [45,49,50,52,57,58]. However, it is unclear if the HFOs rate alone is specific enough to distinguish epileptic from non-epileptic regions at the single electrode level that is required to guide epilepsy surgery.…”

Section: Hfos Rate Amplitude and Durationmentioning

confidence: 99%

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Progress and remaining challenges in the application of high frequency oscillations as biomarkers of epileptic brain

Khadjevand

Cimbálník

Worrell

2017

Current Opinion in Biomedical Engineering

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High-frequency oscillations (HFOs: 100 – 600 Hz) have been widely proposed as biomarkers of epileptic brain tissue. In addition, HFOs over a broader range of frequencies spanning 30 – 2000 Hz are potential biomarkers of both physiological and pathological brain processes. The majority of the results from humans with focal epilepsy have focused on HFOs recorded directly from the brain with intracranial EEG (iEEG) in the high gamma (65 – 100 Hz), ripple (100 – 250 Hz), and fast ripple (250 – 600 Hz) frequency ranges. These results are supplemented by reports of HFOs recorded with iEEG in the low gamma (30 – 65Hz) and very high frequency (500 – 2000 Hz) ranges. Visual detection of HFOs is laborious and limited by poor inter-rater agreement; and the need for accurate, reproducible automated HFOs detection is well recognized. In particular, the clinical translation of HFOs as a biomarker of the epileptogenic brain has been limited by the ability to reliably detect and accurately classify HFOs as physiological or pathological. Despite these challenges, there has been significant progress in the field, which is the subject of this review. Furthermore, we provide data and corresponding analytic code in an effort to promote reproducible research and accelerate clinical translation.

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Comparing late‐onset epileptic spasm outcomes after corpus callosotomy and subsequent disconnection surgery between post‐encephalitis/encephalopathy and non‐encephalitis/encephalopathy

et al. 2023

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Objective: We aimed to analyze the efficiency of corpus callosotomy (CC) and subsequent disconnection surgeries in patients with late-onset epileptic spasms (LOES) by comparing post-encephalitis/encephalopathy (PE) and nonencephalitis/encephalopathy (NE). We hypothesized these surgeries can control potential focal onset epileptic spasms (ES) in the NE group but not in the PE group. Methods:We retrospectively included 23 patients (12 with PE and 11 with NE) who initially underwent CC and subsequent disconnection surgeries (five NE).We compared the clinical courses, seizure types, MRI, video-EEG, epilepsy surgery, and seizure outcomes between the two groups. Results:The median age of LOES onset in the PE group was 2.8 (range 1.0-10.1 years) and 2.9 years (range 1.1-12.6) in the NE group. Bilateral MRI abnormalities were observed in both groups (PE, n = 12; NE, n = 3; P < 0.05). The PE group presented ES alone (n = 2), ES + focal seizures (FS) (n = 3), ES + generalized seizures (GS) (n = 3), and ES + FS + GS (n = 4) in addition to stimulusinduced startle seizures (SS) (n = 8) (mean 3.1 seizure types/patient). The NE group presented ES alone (n = 1), ES + FS (n = 2), and ES + FS + GS (n = 8) (mean 2.7 seizure types/patient). In the PE group, CC stopped ES (n = 1) and SS (n = 1) and achieved <50% SS (n = 3). In the NE group, CC achieved immediate ES-free status (n = 2) and < 50% ES (n = 1), and additional disconnection surgeries subsided all seizure types (n = 3) based on lateralized interictal/ictal EEG findings. LOES was significantly remitted by surgery in the NE group (6/11[55%]) compared with the PE group (1/12 [8%]) (P < 0.05).Significance: LOES is a drug-resistant, focal/generalized/unknown onset ES.

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Epileptogenic high-frequency oscillations skip the motor area in children with multilobar drug-resistant epilepsy

Cited by 29 publications

References 49 publications

Strong coupling between slow oscillations and wide fast ripples in children with epileptic spasms: Investigation of modulation index and occurrence rate

Strong coupling between slow oscillations and wide fast ripples in children with epileptic spasms: Investigation of modulation index and occurrence rate

Progress and remaining challenges in the application of high frequency oscillations as biomarkers of epileptic brain

Comparing late‐onset epileptic spasm outcomes after corpus callosotomy and subsequent disconnection surgery between post‐encephalitis/encephalopathy and non‐encephalitis/encephalopathy

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