Epimerization study of the l,l- and l,d-diastereoisomers of the calpain inhibitor MDL 28170 by capillary electrophoresis

Chen, Teng‐Man; Jones, Harlan K.

doi:10.1016/j.jchromb.2004.05.031

Cited by 6 publications

(10 citation statements)

References 23 publications

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“…Syndecan-1 is expressed in various human cancers and correlates with tumor recurrence in human prostate cancer [121]. Furthermore, it is upregulated in human breast cancer and correlates with poor prognosis [122].…”

Section: Syndecans: Multiple Roles In Cancer Progression and Strategimentioning

confidence: 99%

Proteoglycans in health and disease: novel roles for proteoglycans in malignancy and their pharmacological targeting

et al. 2010

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The expression of proteoglycans (PGs), essential macromolecules of the tumor microenvironment, is markedly altered during malignant transformation and tumor progression. Synthesis of stromal PGs is affected by factors secreted by cancer cells and the unique tumor-modified extracellular matrix may either facilitate or counteract the growth of solid tumors. The emerging theme is that this dual activity has intrinsic tissue specificity. Matrix-accumulated PGs, such as versican, perlecan and small leucine-rich PGs, affect cancer cell signaling, growth and survival, cell adhesion, migration and angiogenesis. Furthermore, expression of cell-surface-associated PGs, such as syndecans and glypicans, is also modulated in both tumor and stromal cells. Cell-surface-associated PGs bind various factors that are involved in cell signaling, thereby affecting cell proliferation, adhesion and motility. An important mechanism of action is offered by a proteolytic processing of cell-surface PGs known as ectodomain shedding of syndecans; this facilitates cancer and endothelial cell motility, protects matrix proteases and provides a chemotactic gradient of mitogens. However, syndecans on stromal cells may be important for stromal cell/cancer cell interplay and may promote stromal cell proliferation, migration and angiogenesis. Finally, abnormal PG expression in cancer and stromal cells may serve as a biomarker for tumor progression and patient survival. Enhanced understanding of the regulation of PG metabolism and the involvement of PGs in cancer may offer a novel approach to cancer therapy by targeting the tumor microenvironment. In this minireview, the implication of PGs in cancer development and progression, as well as their pharmacological targeting in malignancy, are presented and discussed.

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Section: Syndecans: Multiple Roles In Cancer Progression and Strategimentioning

confidence: 99%

Proteoglycans in health and disease: novel roles for proteoglycans in malignancy and their pharmacological targeting

et al. 2010

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“…In this context, rareearth-doped waveguides have been prepared by the Ag 1 2Na 1 thermal assisted ion exchange method using Er 31 and Yb 31 co-doped phosphate glass, attracting great attention in the field of optoelectronic devices. [6][7][8][9][10][11][12][13][14] The preparation of waveguides by the thermally assisted Ag 1 2Na 1 ion-exchange method is a well-established process because the cations have a similar radius (Na 1 5 98 pm and Ag 1 5 113 pm) 15 and because the Na 1 ions also exchange well with Ag 1 ions for waveguide preparation. 7 Moreover, Ag 1 ions present incomplete (nÀ1)d shells being more polarizable than Na 1 ions.…”

Section: Introductionmentioning

confidence: 99%

“…[16][17][18] Phosphate glasses are being used as promising materials applied to photonic devices, such as erbium-doped waveguide amplifiers (EDWA), because they are able to dissolve considerable amounts of active ions that are required to prepare channel waveguide amplifiers. [7][8][9][10][11][12][13] In the case of EDWA, a large amount of Er 31 ions is required due to its small absorption cross section at the excitation region of telecommunication interest and also due to the short length of channel waveguides. Further, the use of considerable amounts of active ions, sensitizing ions such as Yb 31 , may also be required in order to enhance the absorption cross-section at 980 nm and improve the Er 31 ion emission at 1530 nm by nonradiative energy transfer from the sensitizer to the active ions.…”

Section: Introductionmentioning

confidence: 99%

Erbium and Ytterbium Codoped Titanoniobophosphate Glasses for Ion‐Exchange‐Based Planar Waveguides

Bozelli

Nunes

Sígoli

et al. 2010

Journal of the American Ceramic Society

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This work presents the optical properties of erbium-doped and erbium/ytterbium codoped Na 2 O-Al 2 O 3 -TiO 2 -Nb 2 O 5 -P 2 O 5 glass systems and also the characterization of planar waveguides obtained by typical thermally assisted Ag 1 2Na1 ionexchange process. The glass systems allow the preparation of single mode and multimode planar waveguides presenting a strong and relatively broad emission at 1536 nm. The emission signal in the infrared region is intensified for silver-containing samples when compared with free-silver samples. The emission signal intensification may be attributed to a nonplasmonic energy transfer from silver species to Er 31 ions as no bands related to surface plasmon resonance (SPR) of silver nanoparticles were observed.

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“…Up until the present time, many methods, such as spectroscopic techniques 10, 11, HPLC 12, 13 and CE 14, 15 have been used for the kinetic study of epimerization. CE is an important separation technology, offering the advantage of high separation efficiency, short analysis time and minimal sample requirement.…”

Section: Introductionmentioning

confidence: 99%

Determination of the epimerization rate constant of amygdalin by microemulsion electrokinetic chromatography

Zheng

et al. 2010

Electrophoresis

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A new method for separation and determination of amygdalin and its epimer (neoamygdalin) in the epimerization of amygdalin by MEEKC is proposed. For the chiral separation of amygdalin and neoamygdalin, a running buffer composed of 80 mM sodium cholate, 5.0% v/v butan-1-ol, 0.5% v/v heptane and 94.5% v/v 30 mM Na(2) B(4) O(7) buffer (pH 9.00) is proposed. Under optimum conditions, the basic separation of amygdalin and neoamygdalin can be achieved within 7 min. The calibration curve for amygdalin showed excellent linearity in the concentration range of 20-1000 μg/mL with a detection limit of 5.0 μg/mL (S/N=3). The epimerization rate constant of amygdalin in basic microemulsion was first determined by monitoring the concentration changes of amygdalin, and the epimerization rate constant of amygdalin was found to be 2×10(-3) min(-1) at 25°C under the above optimum microemulsion conditions.

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Epimerization study of the l,l- and l,d-diastereoisomers of the calpain inhibitor MDL 28170 by capillary electrophoresis

Cited by 6 publications

References 23 publications

Proteoglycans in health and disease: novel roles for proteoglycans in malignancy and their pharmacological targeting

Proteoglycans in health and disease: novel roles for proteoglycans in malignancy and their pharmacological targeting

Erbium and Ytterbium Codoped Titanoniobophosphate Glasses for Ion‐Exchange‐Based Planar Waveguides

Determination of the epimerization rate constant of amygdalin by microemulsion electrokinetic chromatography

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