Epinephrine as adjuvant for propranolol produces a marked peripheral action in intensifying and prolonging analgesia in response to local dorsal cutaneous noxious pinprick in rats

Tzeng, Jann-Inn; Pan, He-Jia; Liu, Kuo‐Sheng; Chen, Yu‐Wen; Chen, Yu-Chung; Wang, Jhi-Joung

doi:10.1016/j.ejphar.2014.06.029

Cited by 13 publications

(2 citation statements)

References 46 publications

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“…Using the cutaneous trunci pinprick model 36 , we evaluated the effects of subcutaneous infiltration of novel derivatives, each at a concentration of 62.3 mmol/L, equivalent to half the clinical concentration of AT . This concentration ensured local anesthesia in the rats without adverse reactions.…”

Section: Resultsmentioning

confidence: 99%

Deep simulated annealing for the discovery of novel dental anesthetics with local anesthesia and anti-inflammatory properties

Hao,

Wang,

Liu

et al. 2024

Acta Pharmaceutica Sinica B

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Section: Resultsmentioning

confidence: 99%

Deep simulated annealing for the discovery of novel dental anesthetics with local anesthesia and anti-inflammatory properties

Hao,

Wang,

Liu

et al. 2024

Acta Pharmaceutica Sinica B

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“…Each dose—response curve was fitted using the SAS Nonlinear (NLIN) Procedures (SAS Institute Inc., Carey, NC, USA). Furthermore, the ED 25 and ED 75 of mepivacaine, doxylamine and triprolidine were calculated using the same SAS NLIN Procedures which were employed to obtain their ED 50 s …”

Section: Methodsmentioning

confidence: 99%

Spinal sensory and motor blockade by intrathecal doxylamine and triprolidine in rats

Tzeng

Chiu

Wang

et al. 2018

Journal of Pharmacy and Pharmacology

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Objectives The aim of this experiment was mainly to examine the effects of intrathecally injected doxylamine and triprolidine, two antihistamine drugs spinal motor and sensory functions. Methods After intrathecally injecting the rats with five different doses, the dose—response curves of spinal sensory and motor block with doxylamine and triprolidine were constructed. In comparison with the local anaesthetic mepivacaine, the quality and duration of spinal anaesthesia with doxylamine or triprolidine were conducted. Key findings Doxylamine, mepivacaine and triprolidine elicited spinal motor and sensory (nociception and proprioception) blockades in a dose‐dependent fashion. On the ED50 (50% effective dose) basis, the rank order of drug potency was triprolidine > mepivacaine > doxylamine (P < 0.05) at provoking spinal motor, proprioceptive and nociceptive blockades. On the equianaesthetic doses (ED25, ED50 and ED75), the duration of spinal anaesthesia with doxylamine was longer (P < 0.01) than that with mepivacaine or triprolidine. Moreover, doxylamine or triprolidine displayed greater potency (ED50) (P < 0.05) and duration (P < 0.05) of sensory block over motor block. Conclusions Doxylamine or triprolidine produces a dose‐dependent effect of spinal motor and sensory block. Triprolidine with a better nociception‐selective action over motor block has a better potency than mepivacaine or doxylamine. Doxylamine and triprolidine produce longer durations than mepivacaine.

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Thermodynamic dependence of the electrochemical oxidation of dihydroxybenzenes in the presence of some Meldrum's acids

2019

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Epinephrine as adjuvant for propranolol produces a marked peripheral action in intensifying and prolonging analgesia in response to local dorsal cutaneous noxious pinprick in rats

Cited by 13 publications

References 46 publications

Deep simulated annealing for the discovery of novel dental anesthetics with local anesthesia and anti-inflammatory properties

Deep simulated annealing for the discovery of novel dental anesthetics with local anesthesia and anti-inflammatory properties

Spinal sensory and motor blockade by intrathecal doxylamine and triprolidine in rats

Thermodynamic dependence of the electrochemical oxidation of dihydroxybenzenes in the presence of some Meldrum's acids

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