Episodic and Semantic Autobiographical Memory in Mild Cognitive Impairment (MCI): A Systematic Review

Abstract

Introduction: Mild cognitive impairment (MCI) is a syndrome defined as a decline in cognitive performance greater than expected for an individual according to age and education level, not interfering notably with daily life activities. Many studies have focused on the memory domain in the analysis of MCI and more severe cases of dementia. One specific memory system is represented by autobiographical memory (AM), which has been largely studied in Alzheimer’s disease and its effect on AM; however, the impairment of AM in moderate forms of decline, such as MCI, is still controversial. Objective: The main aim of this systematic review is to analyze the functioning of autobiographical memory in patients with MCI, considering both the semantic and the episodic components. Materials: The review process was conducted according to the PRISMA statement. The search was conducted until 20 February 2023 in the following bibliographical databases: PubMed, Web of Science, Scopus, and PsycInfo, and twenty-one articles were included. Results: The results highlight controversial findings concerning the semantic component of AM since only seven studies have found a worse semantic AM performance in patients with MCI compared to the HC group. The results of impaired episodic AM in individuals with MCI are more consistent than those concerning semantic AM. Conclusions: Starting from the evidence of this systematic review, further studies should detect and investigate the cognitive and emotional mechanisms that undermine AM performance, allowing the development of specific interventions targeting these mechanisms.

The protective role of cognitive reserve: an empirical study in mild cognitive impairment

“…An additional limitation of this study is that it focuses solely on cognitive aspects and does not consider biological factors such as APOE ε4. This omission could impact the severity and trajectory of Mild Cognitive Impairment Furthermore, it might be interesting to evaluate the relationship of CR not only with global cognitive functioning (e.g., MMSE) but also with specific cognitive functions that are impaired in MCI, such as simple and higher executive functions, attentional processes and their interaction with complex executive functions, or more complex memory functions [51][52][53][54][55][56][57][58]. The use of MMSE as a screening tool in healthy and MCI populations may present limitations due to its poor sensitivity in discriminating between these two groups.…”