Episodic and semantic memory in mild cognitive impairment

Dudás, Róbert B.; Clague, Fiona; Thompson, Sian; Graham, Kim S.; Hodges, John R.

doi:10.1016/j.neuropsychologia.2004.12.005

Cited by 144 publications

(102 citation statements)

References 52 publications

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“…Consistent with previous reports, 21,35,36 our CDR 0.5 cohort showed impairment in baseline episodic memory compared to controls, with less severe impairment in semantic memory, working memory, and visuospatial composite scores. Clinicopathologic and radiologic studies suggest that hippocampal and parahippocampal regions mediate episodic memory functions, 35,37 while polar temporal, inferior temporal, and anterior fusiform regions are implicated in semantic memory.…”

Section: Rates Of Decline In (A and B) Clinical Dementia Rating-sum Osupporting

confidence: 92%

“…Clinicopathologic and radiologic studies suggest that hippocampal and parahippocampal regions mediate episodic memory functions, 35,37 while polar temporal, inferior temporal, and anterior fusiform regions are implicated in semantic memory. 38 Our observation that VILIP-1 levels correlate with decline in episodic and semantic memory is consistent with early involvement of medial temporal and fusiform regions (respectively) by AD pathology, 39 and with our findings that CSF VILIP-1 levels correlate with atrophy of these regions in early AD.…”

Section: Rates Of Decline In (A and B) Clinical Dementia Rating-sum Omentioning

confidence: 99%

See 1 more Smart Citation

CSF VILIP-1 predicts rates of cognitive decline in early Alzheimer disease

Tarawneh¹,

J²,

Ladenson³

et al. 2012

Neurology

105

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Objective: Measures of neuronal damage/dysfunction are likely good surrogates for disease progression in Alzheimer disease (AD). CSF markers of neuronal injury may offer utility in predicting disease progression and guiding prognostic and outcome assessments in therapeutic trials. Visinin-like protein-1 (VILIP-1) has demonstrated potential utility as a marker of neuronal injury. We here investigate the utility of VILIP-1 and VILIP-1/A␤42 in predicting rates of cognitive decline in early AD.Methods: Individuals with a clinical diagnosis of very mild or mild AD (n ϭ 60) and baseline CSF measures of VILIP-1, tau, p-tau181, and A␤42 were followed longitudinally for an average of 2.6 years. Annual assessments included the Clinical Dementia Rating (CDR), CDR-sum of boxes (CDR-SB), and global composite scores. Mixed linear models assessed the ability of CSF biomarker measures to predict rates of cognitive decline over time.Results: Baseline CSF VILIP-1 and VILIP-1/A␤42 levels predicted rates of future decline in CDR-SB and global composite scores over the follow-up period. Individuals with CSF VILIP-1 Ն560 pg/mL (corresponding to the upper tercile) progressed much more rapidly in CDR-SB (1.61 boxes/year; p ϭ 0.0077) and global scores (Ϫ0.53 points/year; p ϭ 0.0002) than individuals with lower values (0.85 boxes/year and Ϫ0.15 points/year, respectively) over the follow-up period. CSF tau, p-tau181, tau/A␤42, and p-tau181/A␤42 also predicted more rapid cognitive decline in CDR-SB and global scores over time. Conclusion:These findings suggest that CSF VILIP-1 and VILIP-1/A␤42 predict rates of global cognitive decline similarly to tau and tau/A␤42, and may be useful CSF surrogates for neurodegeneration in early AD. Neurology The aggregation and deposition of amyloid-␤ and tau, the 2 key proteins involved in Alzheimer disease (AD) pathogenesis, are estimated to begin years prior to the onset of cognitive impairment.1,2 However, it is only after a threshold of neuronal loss is reached in vulnerable brain regions that the first signs of cognitive impairment appear. Several lines of evidence suggest that neuronal and synaptic loss is the best surrogate for disease progression and cognitive decline in AD.2,4 While CSF tau and amyloid-beta 1-42 (A␤42) each predominantly reflect a specific AD pathology, neuronal injury/neurodegeneration likely represents the cumulative outcome of different pathologic substrates. Therefore, CSF markers of neuronal injury, along with CSF tau and A␤42, may offer utility in predicting disease progression and future cognitive decline in the early stages of disease.

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Section: Rates Of Decline In (A and B) Clinical Dementia Rating-sum Osupporting

confidence: 92%

Section: Rates Of Decline In (A and B) Clinical Dementia Rating-sum Omentioning

confidence: 99%

CSF VILIP-1 predicts rates of cognitive decline in early Alzheimer disease

Tarawneh¹,

J²,

Ladenson³

et al. 2012

Neurology

105

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“…Performance on most nonmemory tests was largely intact except for comparatively low output on the "animal" fl uency test. Low output on semantically guided fl uency tests in a group of individuals with anterograde amnesia might suggest the presence of concomitant semantic memory defi cits (Adlam, Bozeat, Arnold, Watson, & Hodges, 2006 ;Carew et al, 1997 ;Dudas, Clague, Thompson, Graham, & Hodges, 2005 ;Murphy, Rich, & Troyer, 2006 ). Howieson at al.…”

Section: Discussionmentioning

confidence: 99%

The heterogeneity of mild cognitive impairment: A neuropsychological analysis

Libon

Xie

Eppig

et al. 2009

J Int Neuropsychol Soc

114

122

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A group of 94 nondemented patients self-referred to an outpatient memory clinic for memory diffi culties were studied to determine the incidence of single versus multi-domain mild cognitive impairment (MCI) using Petersen criteria. Fifty-fi ve community dwelling normal controls (NC) participants without memory complaints also were recruited. Tests assessing executive control, naming/lexical retrieval, and declarative memory were administered. Thirty-four patients exhibited single-domain MCI, 43 patients presented with multi-domain MCI. When the entire MCI sample ( n = 77) was subjected to a cluster analysis, 14 patients were classifi ed with amnesic MCI, 21 patients with dysexecutive MCI, and 42 patients were classifi ed into a mixed/multi-domain MCI group involving low scores on tests of letter fl uency, "animal" fl uency, and delayed recognition discriminability. Analyses comparing the three cluster-derived MCI groups versus a NC group confi rmed the presence of memory and dysexecutive impairment for the amnesic and dysexecutive MCI groups. The mixed MCI group produced lower scores on tests of letter fl uency compared with the amnesic MCI and NC groups and lower scores on tests of naming and memory compared with the NC group. In summary, multi-domain MCI is quite common. These data suggest that MCI is a highly nuanced and complex clinical entity. ( JINS , 2010, 16, 84-93.)

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“…For example, Delazer et al 5 showed that retrieval of people names was normal in a group of MCI patients in comparison with healthy controls. In contrast, Dudas et al 6 and Adlam et al 7 , by using a more comprehensive test battery, found semantic memory deficits particularly in the item recognition, cross-modal associative memory and semantic knowledge for people in MCI patients. We have found that aMCI impairs episodic memory while sparing lexical semantic system, which can be affected in the early phase of AD.…”

Section: Figure Distribution Of Mean Scores Of Ad Amci and Control mentioning

confidence: 88%

“…Thus, its deficit signifies the loss of concepts that have been part of one's store of knowledge 3,4 . Semantic memory in MCI is not enough investigated and some studies are controversial concerning its impairment [5][6][7] . Several approaches can be made to study semantic memory, like tests of priming, general knowledge, category fluency and object or picture naming 8 .…”

mentioning

confidence: 99%

Lexical semantic memory in amnestic mild cognitive impairment and mild Alzheimer's disease

Balthazar

Martinelli

Cendes

et al. 2007

Arq. Neuro-Psiquiatr.

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-Objective: To study lexical semantic memory in patients with amnestic mild cognitive impairment (aMCI), mild Alzheimer's disease (AD) and normal controls. Method: Fifteen mild AD, 15 aMCI, and 15 normal control subjects were included. Diagnosis of AD was based on DSM-IV and NINCDS-ADRDA criteria, and that of aMCI, on the criteria of the International Working Group on Mild Cognitive Impairment, using CDR 0.5 for aMCI and CDR 1 for mild AD. All subjects underwent semantic memory tests (Boston Naming-BNT, CAMCOG Similarities item), Rey Auditory Verbal Learning Test (RAVLT), Mini-Mental Status Examination (MMSE), neuropsychological tests (counterproofs), and Cornell Scale for Depression in Dementia. Data analysis used Mann-Whitney test for intergroup comparisons and Pearson's coefficient for correlations between memory tests and counterproofs (statistical significance level was p<0.05). Results: aMCI patients were similar to controls on BNT and Similarities, but worse on MMSE and RAVLT. Mild AD patients scored significantly worse than aMCI and controls on all tests. Conclusion: aMCI impairs episodic memory but tends to spare lexical semantic system, which can be affected in the early phase of AD.KEy WORDS: semantic memory, mild cognitive impairment, Alzheimer's disease, neuropsychological tests.Memória léxico-semântica no comprometimento cognitivo leve amnéstico e doença de Alzheimer leve RESUMO -Objetivo: Estudar a memória léxico-semântica no comprometimento cognitivo leve amnésti-co (aCCL), doença de Alzheimer (DA) leve e controles normais. Método: Incluímos 15 pacientes com DA leve, 15 com aCCL e 15 controles normais, usando os critérios DSM-IV, NINCDS-ADRDA e CDR 1 para DA, e os do International Working Group on Mild Cognitive Impairment, e CDR 0,5 para aCCL. Todos os sujeitos passaram por testes de memória semântica (Teste de nomeação de Boston -TNB, item de Similaridades do CAMCOG), teste de aprendizado auditivo-verbal de Rey (TAAVR), Mini-Exame do Estado Mental (MEEM), testes neuropsicológicos (contraprovas) e Escala Cornell para Depressão em Demência. A análise dos dados usou o teste de Mann-Whitney para comparações entre os grupos e o coeficiente de Pearson para correlação entre testes e contraprovas (nível de significância p<0,05). Resultados: Os pacientes com aCCL foram semelhantes aos controles no TNB e Similaridades, mas inferiores no MEEM e TAAVR. Pacientes com DA leve tiveram performance inferior à de sujeitos com aCCL e controles em todos os testes. Conclusão: O aCCL prejudica a memória episódica, mas tende a poupar o sistema léxico-semântico, que pode estar afetado na fase inicial da DA. PALAVRAS-ChAVE: memória semântica, comprometimento cognitivo leve, doença de Alzheimer, testes neuropsicológicos.

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Episodic and semantic memory in mild cognitive impairment

Cited by 144 publications

References 52 publications

CSF VILIP-1 predicts rates of cognitive decline in early Alzheimer disease

CSF VILIP-1 predicts rates of cognitive decline in early Alzheimer disease

The heterogeneity of mild cognitive impairment: A neuropsychological analysis

Lexical semantic memory in amnestic mild cognitive impairment and mild Alzheimer's disease

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