Epithelial Cell Death in the Oil-Induced Decidual Reaction of the Pseudopregnant Mouse: An Ultrastructural Study

Hinchliffe, J. R.; El-Shershaby, A. M.

doi:10.1530/jrf.0.0450463

Cited by 20 publications

(13 citation statements)

References 8 publications

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“…106 This response elicits the formation of a deciduomata that is very similar (albeit not identical 107 ) to true decidua. Extensive observations based on this model have confirmed that the pseudo-decidual reaction is followed by the involution of the anti-mesometrial region 108 and preceded by the degradation of the luminal epithelium (in the rat, 109 in the mouse 110,111 ). Epithelial cells in the antimesometrial zone seem to detach progressively from the basal lamina and show clear signs of degradation (condensation and margination of the nuclear chromatin and dilation of the endoplasmic reticulum) which resemble those detected during normal implantation.…”

Section: Mechanisms Of Cell Death In the Uterusmentioning

confidence: 73%

Apoptosis at the time of embryo implantation in mouse and rat

1999

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The aim of this review is to summarize the information currently available regarding the occurrence of apoptosis in the developing embryo and in the receptive uterus during the peri-implantation period of gestation. Cell death is detected in the inner cell mass of late pre-implantation embryos as the result of an eliminative process that helps trim the embryonic cell lineages of surplus or dysfunctional stem cells. Cell death is also detected in the epiblastic core of early postimplantation embryos, where the process is implicated in the formation of the pro-amniotic cavity. On the maternal side, uterine epithelial cells situated around the attachment site undergo cell death during the initial phase of implantation in order to facilitate embryo anchorage and access to maternal blood supply. Uterine stromal cells closest to the implantation chamber first transform into decidual cells and then commit suicide to make room for the rapidly growing embryo. Although apoptosis is well recognized as a crucial determinant of successful peri-implantation development, our understanding of the cellular and molecular mechanisms regulating this process clearly lags behind the comprehension of cell death control in other systems.

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Section: Mechanisms Of Cell Death In the Uterusmentioning

confidence: 73%

Apoptosis at the time of embryo implantation in mouse and rat

1999

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“…The breakdown of the epithelial cells has been studied in detail by Hinchliffe and El-Shershaby (1975), who have similarly concluded that it is a result of autolytic breakdown.…”

Section: Epithelial Changesmentioning

confidence: 99%

The Implantation Reaction

Finn

1977

Biology of the Uterus

171

121

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Implantation involves the attachment of the blastocyst to the wall of the uterus with, in some cases, the embedding of the entire ovum in the uterine wall. Associated with it are very profound and characteristic changes in the endometrium both during preparation for implantation and following attachment of the blastocyst. In this chapter, the uterine changes that take place during preparation will be considered first and then the changes during the process of implantation. The former occur regularly and frequently throughout the life of most female mammals, whereas the latter are rarer events, especially in women. This division of the subject is also convenient for the consideration of the control mechanism involved. Whereas the preparative changes are largely directed by the varying levels of the hormones secreted by the ovary, once the implantation process has been initiated hormones playa largely permissive role.There is considerable species variation in the reaction of the uterus in preparation for and during implantation. De Feo (1967) reviewed this subject very thoroughly in the first edition of this book. The great majority of research investigations have been carried out on laboratory rodents, with very little on primates or the larger domestic animals. It follows therefore that any general account of implantation will lean heavily on information acquired from laboratory animals. Although one would like to have a much more general coverage, one cannot escape the reality that information acquired from many experiments on large numbers of laboratory animals provides a sound foundation on which to build. Information from primates or wild mammals will always tend to be fragmentary because of the difficulty of obtaining large numbers of specimens. Anyone who has worked with rats or mice knows how easy it is to be misled by the results from two or three animals. The only sensible course therefore is to get as

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“…The injection of oil into the uterine lumen of an appropriately treated mouse does not result in the induction of decidualization evenly along the entire length of the horn but in a series of foci of decidual induction (Hinchliffe & El-Shershaby, 1975;Lundkvist et ai, 1977). These foci of decidual induction grow to give a series of discrete swellings along the length of the horn (Finn & Hinchliffe, 1964).…”

Section: Resultsmentioning

confidence: 99%

“…The even spacing of used sites along the uterus reflects the even spacing of implantation sites which is accomplished by a combination of muscular activity and differential growth (Finn, 1977). Oil injected into the lumen is broken up into droplets some of which become located in the antimesometrial extremity of the lumen, as do blastocysts (Hinchliffe & El-Shershaby, 1975;Martin, 1979). The post-partum nodule interrupts the continuity of the circular muscle layer in the rodent uterus (Selye & McKeown, 1935;Deno, 1937) and it is possible that the presence of post-partum nodules could affect the circular muscle contraction which is associated with the antimesometrial placement of oil droplets or blastocysts (Martin, 1979).…”

Section: Resultsmentioning

confidence: 99%

Decidualization in the post-partum uterus of the mouse

Brandon

1990

Reproduction

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Summary. Unilaterally ovariectomized mice were allowed to complete one pregnancy before the second ovary was removed and sensitivity to decidualization was induced by hormone administration. The virgin uterine horn and the post-partum horn were stimulated to decidualize by the intraluminal injection of arachis oil. A greater decidual response was found in post-partum horns than in virgin horns. The foci of decidual induction in post-partum horns were regularly spaced reflecting the regular spacing of used and unused areas of the uterus. A focus of decidual induction occurred in 68% of the recently used uterine areas observed, i.e. areas associated with post-partum nodules. When compared with foci of decidualization in adjacent unused areas of the uterus, none of the decidualized used zones showed more decidual tissue, about half showed less decidual tissue and half showed the same amount of decidual tissue. The remaining 32% of used zones were not associated with foci of decidual induction. The results indicate that decidualization can be induced in recently used zones of the uterus using a non-traumatic method of induction, but that used zones are associated with less decidual tissue than unused zones of the post-partum uterus.

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Epithelial Cell Death in the Oil-Induced Decidual Reaction of the Pseudopregnant Mouse: An Ultrastructural Study

Cited by 20 publications

References 8 publications

Apoptosis at the time of embryo implantation in mouse and rat

Apoptosis at the time of embryo implantation in mouse and rat

The Implantation Reaction

Decidualization in the post-partum uterus of the mouse

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