2016
DOI: 10.1073/pnas.1614970113
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Epithelial cell integrin β1 is required for developmental angiogenesis in the pituitary gland

Abstract: As a key component of the vertebrate neuroendocrine system, the pituitary gland relies on the progressive and coordinated development of distinct hormone-producing cell types and an invading vascular network. The molecular mechanisms that drive formation of the pituitary vasculature, which is necessary for regulated synthesis and secretion of hormones that maintain homeostasis, metabolism, and endocrine function, remain poorly understood. Here, we report that expression of integrin β1 in embryonic pituitary ep… Show more

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Cited by 19 publications
(17 citation statements)
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“…in angiogenesis has become an important investigation subject, which regulates sprouting, branching, adhesion and cell survival. 34,35 In our study, the protein expression of β1 integrin increased after 30 Hz, 3.0 mT PEMF intervention. Therefore, the effect of physical force on angiogenesis may be related to integrin.…”
Section: Pemfs Improve Angiogenesis In Vivosupporting
confidence: 50%
“…in angiogenesis has become an important investigation subject, which regulates sprouting, branching, adhesion and cell survival. 34,35 In our study, the protein expression of β1 integrin increased after 30 Hz, 3.0 mT PEMF intervention. Therefore, the effect of physical force on angiogenesis may be related to integrin.…”
Section: Pemfs Improve Angiogenesis In Vivosupporting
confidence: 50%
“…Integrins are cell membrane heterodimeric receptors that mediate cell-to-cell and cell-to-matrix adhesion. The expression and roles of integrins in the pituitary gland have been studied previously (88, 89). Here we show that seven genes from this family are also expressed in anterior pituitary; all of them were identified in FSC and Itga3, Itgab1 , and Itgae in all HPC types as well.…”
Section: Discussionmentioning
confidence: 99%
“…Expression analysis of both mouse and human tissue revealed that in development, FAT/DCHS protocadherins are expressed in the mesenchyme surrounding the pituitary. The infundibulum and posterior pituitary gland receive a rich blood supply from the superior hypophyseal artery, infundibular artery, and inferior hypophyseal artery ( 32 ), all of mesenchymal origin ( 28 , 33 ). Disruption of the pituitary vascular network can result in abnormal tissue morphology and poor function ( 28 , 33 ).…”
Section: Discussionmentioning
confidence: 99%