Epitranscriptomic regulation in fasting hearts: implications for cardiac health

Benak, Daniel; Holzerova, Kristyna; Hrdlicka, Jaroslav; Kolar, Frantisek; Olsen, Mark; Karelson, Mati; Hlavackova, Marketa

doi:10.1080/15476286.2024.2307732

RNA Biology

2024

DOI: 10.1080/15476286.2024.2307732

|View full text |Cite

Epitranscriptomic regulation in fasting hearts: implications for cardiac health

Daniel Benak,

Kristyna Holzerova,

Jaroslav Hrdlicka

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

2025

Publication Types

Select...

Article5

Relationship

Self Cite0

Independent5

Authors

Journals

Cited by 6 publications

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

m6A Ribonucleic Acid Methylation in Fibrotic Diseases of Visceral Organs

Dai,

Cheng,

Luo

et al. 2024

Small Science

View full text Add to dashboard Cite

Fibrosis is a pathological process characterized by the excessive deposition of extracellular matrix in the tissue's extracellular space, leading to structural injury and organ dysfunction, and even organ failure, posing a threat to human life. Despite mounting evidence suggesting that fibrosis is reversible, effective treatments for fibrotic diseases are lacking. Accumulating evidence has elucidated that ribonucleic acid (RNA) modifications have emerged as novel mechanisms regulating gene expression. N6‐methyladenosine (m6A) modification is a well‐known prevalent RNA posttranscriptional modification that participates in essential biological processes such as RNA splicing, translation, and degradation. It is tightly implicated in a wide range of cellular processes and various human diseases, particularly in organ fibrosis. The m6A modification is a dynamic and reversible process regulated by methylases, commonly known as “writers,” and demethylases referred to as “erasers,” while m6A modifications are recognized by “readers.” Accumulating evidence suggests that m6A modification on RNAs is tightly associated with fibrotic diseases of visceral organs including the lungs, heart, liver, and kidney. In this review, recent advances in the impact of m6A methylation of RNAs on visceral organ fibrosis are highlighted and the potential prospects for therapy in treating fibrotic diseases of visceral organs are discussed.

show abstract

m6A Ribonucleic Acid Methylation in Fibrotic Diseases of Visceral Organs

Dai,

Cheng,

Luo

et al. 2024

Small Science

View full text Add to dashboard Cite

show abstract

ALKBH5 deletion ameliorates inflammation by regulating IRF3 signaling in an m6A-dependent manner after myocardial infarction

Zhao,

Liang,

Zhao

et al. 2025

Biochemical and Biophysical Research Communications

View full text Add to dashboard Cite

Epitranscriptomic regulations in the heart

Benak,

Kolar,

Hlavackova

2024

Physiol Res

View full text Add to dashboard Cite

RNA modifications affect key stages of the RNA life cycle, including splicing, export, decay, and translation. Epitranscriptomic regulations therefore significantly influence cellular physiology and pathophysiology. Here, we selected some of the most abundant modifications and reviewed their roles in the heart and in cardiovascular diseases: N6-methyladenosine (m6A), N6,2‘-O-dimethyladenosine (m6Am), N1-methyladenosine (m1A), pseudouridine (Ψ), 5 methylcytosine (m5C), and inosine (I). Dysregulation of epitranscriptomic machinery affecting these modifications vastly changes the cardiac phenotype and is linked with many cardiovascular diseases such as myocardial infarction, cardiomyopathies, or heart failure. Thus, a deeper understanding of these epitranscriptomic changes and their regulatory mechanisms can enhance our knowledge of the molecular underpinnings of prevalent cardiac diseases, potentially paving the way for novel therapeutic strategies.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Epitranscriptomic regulation in fasting hearts: implications for cardiac health

Cited by 6 publications

References 55 publications

m6A Ribonucleic Acid Methylation in Fibrotic Diseases of Visceral Organs

m6A Ribonucleic Acid Methylation in Fibrotic Diseases of Visceral Organs

ALKBH5 deletion ameliorates inflammation by regulating IRF3 signaling in an m6A-dependent manner after myocardial infarction

Epitranscriptomic regulations in the heart

Contact Info

Product

Resources

About