Epoxy-Terminated Self-Assembled Monolayers:  Molecular Glues for Polymer Layers

Luzinov, Igor; Julthongpiput, Duangrut; Liebmann-Vinson, Andrea; Cregger, T.; Foster, and Mark D.; Tsukruk, Vladimir V.

doi:10.1021/la990500+

Cited by 194 publications

(197 citation statements)

References 36 publications

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“…The silanization has been extensively studied in literature, and was therefore not further investigated. [142,[149][150] However, up-scaling of the reaction to coat the 22 x 21 cm² laser printer slides is still an on-going process. So far, only "lower quality" coatings could be achieved even if higher concentrations of 3-GPS in the silanization step were applied.…”

Section: Discussionmentioning

confidence: 99%

“…[149] A more recent publication by WONG et al determined thicknesses of 11±3.5 Ǻ by ellipsometry. [150] The composition of the SAM was checked by XPS both on microscopy slide glass and on Si(100).…”

Section: First Aeg3 Sams On Si(100) and Glassmentioning

confidence: 99%

“…[144] The resulting "good" AEG3 SAM quality (see Figure 29, reference slide) is in good agreement with LUZINOV et al who reported a decreasing 3-GPS SAM quality as less 3-GPS was used in their solution approach. [149] Formation of multilayers for low 3-GPS concentrations was explained by a high loss of 3-GPS due to hydrolization. Therefore, it can be assumed that the less water is present in the solvents and the more careful the surfaces are dried the better is the resulting 3-GPS film quality even if assembled from solution.…”

Section: Parameters Determining the Quality Of Aeg3 Samsmentioning

confidence: 99%

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Purification of Peptides in High-Complexity Arrays

Schirwitz

2013

Springer Theses

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Compared to the human genome, which is formed by approximately 25,000 genes, the human proteome comprises over a million functional proteins and thus represents a much higher diversity. Although genetic research provides valuable information on the proteins which can be translated, a great task in the future will be the exploration of the entire protein interaction network. Understanding protein interactions will greatly help scientists to identify the mechanisms behind fatal diseases such as cancer, AIDS, and tuberculosis and, hopefully, provide new

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Section: Discussionmentioning

confidence: 99%

Section: First Aeg3 Sams On Si(100) and Glassmentioning

confidence: 99%

Section: Parameters Determining the Quality Of Aeg3 Samsmentioning

confidence: 99%

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Purification of Peptides in High-Complexity Arrays

Schirwitz

2013

Springer Theses

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“…But the shape remained spherical. Since the thickness of a GPTMS monolayer is reported to be 0.8 nm [27] , it can be inferred from the 17 nm increase in particle size that an equivalent of about 20 layers of GPTMS was formed on the surface of silica nanoparticles. Higher GPTMS concentration (5% and 10%) and longer reaction time up to 24 h did not increase the particle size any further (Figure 1(c)), suggesting that the surface silanization reaction was complete within 1h even with only 1% GPTMS.…”

Section: Epoxysilane Modification Of Silica Nanoparticlesmentioning

confidence: 99%

One-step and high-density protein immobilization on epoxysilane-modified silica nanoparticles

2009

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Silica nanoparticles are most commonly modified with amino-silanes, followed by post-modification activation for protein immobilization. In this work, epoxy-functionalized silica nanoparticles were prepared by modification with glycidyloxypropyl trimethoxysilane (GPTMS) for direct protein immobilization. Silica nanoparticles possessed an average size of 46 nm, but increased to 63 nm after GPTMS modification. Reaction time, reaction temperature and GPTMS content had no significant effect on particle size. Zeta potential of SiO 2 changed from −26mV to +38mV after modification. Fourier-transformed infrared spectroscopy revealed alkyl C-H bending and stretching bands at 2944 cm −1 , 1343 cm −1 and 1465 cm −1 , respectively, for the modified nanoparticles. Fluorescein cadaverine was found to bind to GPTMS-modified SiO 2 , but not to bare SiO 2 , indicating the chemical reactivity of epoxy groups on the modified nanoparticle with amines. Finally, fluorescently labeled bovine serum albumin (BSA) was used as a model protein to investigate the capacity of epoxy-SiO 2 nanoparticles for protein immobilization. The results showed that more proteins were immobilized on the particle with longer reaction time, higher NaCl concentration, lower pH, and less GPTMS content. More importantly, proteins bound to epoxy-SiO 2 nanoparticle were highly stable. Under optimized reaction conditions, as much as 25 mg BSA/g nanoparticle was covalently attached to the nanoparticle. The epoxy silane modification of silica nanoparticles offers a reactive surface for one-step and high-density protein immobilization. epoxysilane, silica nanoparticle, protein immobilizationIn the past few years, nanomaterials of various shapes (particles, wires, rods, tubes, etc.) have been synthesized and characterized. They have been found to possess unique size-dependent properties in terms of quantum effect, specific surface area, electric conductivity, mechanical strength, and catalytic reactivity [1] . Consequently, nanomaterials have been found wide applications in the field of biological analysis and detection, biological imaging and drug delivery [2,3] . Among them, silica nanoparticles have been studied extensively due to their easy synthesis, readily available surface modification, good dispersibility and stability in water, and biocompatibility [4] . Mesoporous silica nanoparticles can be employed as drug delivery vehicles for controlled release [5] . Surface-coated silica nanoparticles act as a carrier for multiple optical [6,7] and electrochemical [8] labels to enhance detection signal. Dye-doped silica nanoparticles are more resistant to photo-bleaching than fluorescent dye molecules and much less toxic than quantum dots. They therefore offer distinct advantages when applied to in vivo fluorescence imaging [9,10] . Ruthenium tris(bipyridyl)-doped silica nanoparticles [11][12][13] have been used as electrochemiluminescent labels to provide large quantities of Ru(bpy) 3 2+ molecules for signal detection. Furthermore, silica coating on other

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“…This leads to complete surface wetting under normal air/fluid conditions, and to the formation of very strong capillary forces between micrometer-sized parts. 8 Integration of sensing and computing to actuation is currently in its embryonic stage.…”

Section: General Introduction To Nanolubricationmentioning

confidence: 99%

Design of nanocomposite polymer coatings for MEMS applications

Julthongpiput

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Epoxy-Terminated Self-Assembled Monolayers: Molecular Glues for Polymer Layers

Cited by 194 publications

References 36 publications

Purification of Peptides in High-Complexity Arrays

Purification of Peptides in High-Complexity Arrays

One-step and high-density protein immobilization on epoxysilane-modified silica nanoparticles

Design of nanocomposite polymer coatings for MEMS applications

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