Epstein barr virus associated Hodgkin and non-Hodgkin lymphoma

Abstract

Background: The Epstein-Barr virus (EBV) has been linked to a variety of B-cell lymphomas, including Burkitt lymphoma (BL), classical Hodgkin lymphoma (cHL), and diffuse large B-cell lymphoma (DLBCL), at rates ranging from 5 to 10% of DLBCL cases to >95% in endemic BL. Methods: The Present study conducted in AL-Najaf Holy City; it is a cross sectional study. All patients were recruited from Middle Euphrates Cancer Research Unit Laboratory, from pre-existing samples. Tissues collected from the previously mentioned laboratory were fixed in 10% formalin and placed in a cassette before being embedded in paraffine. The tissues were examined and diagnosed as with Hodgkin disease. Eighty samples were subjected in the present study. All study group was diagnosed formerly as paraffin imbedding blocks. Molecular analysis also used to detection of EBV-LMP-1 Gene. Histopathological examination using hematoxylin and eosine stain (H&E) then examining under light microscope to check for EBV-LMP-1 protein in twenty block samples of tissues with lymphoma. Results: The result of the current study revealed that EBV-LMP-1 marker found in 12.5% of cases that had been diagnosed by PCR and IHC.