Epstein-Barr virus is associated with all histological subtypes of Hodgkin lymphoma in Vietnamese children with special emphasis on the entity of lymphocyte predominance subtype

Chang, Kung-Chao; Khen, Nguyen Thi; Jones, Dan; Su, Ih‐Jen

doi:10.1016/j.humpath.2005.05.003

Cited by 50 publications

(43 citation statements)

References 34 publications

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“…For children (Table 4), the frequency of EBV-positive cases was very high-ranging from 83% to 100%-in the nine developing countries [15,30,[47][48][49][50][51][52]. This is in contrast to the low frequencies (35% to 38%) found in the USA [47], the United Arab Emirates [56], and the UK [57].…”

Section: Discussionmentioning

confidence: 99%

“…As there is a high incidence of EBV-positive HL in the pediatric age group, the number of pediatric cases included in the various studies may influence the overall EBV positivity rate. The percentage of EBV-associated pediatric cHL (Table 4) ranged from 51% of EBV-associated cHL in one series from the UK [55] to 100% in Peru [17], Honduras [47], and Kenya [15], with the percentages in six other countries ranging from 83-97% [30,[48][49][50][51].…”

Section: Discussionmentioning

confidence: 99%

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Epstein–Barr virus and Hodgkin’s lymphoma in Cairo, Egypt

et al. 2010

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Fifty-five consecutive cases of Hodgkin's lymphoma (HL), collected between 1996 and 1998 from Cairo, Egypt, were histologically subtyped, phenotyped, and then studied for the presence of Epstein-Barr virus (EBV). We used immunohistochemical stains for EBV latent membrane protein 1 (LMP-1) and in situ hybridization stains for EBV-encoded small RNA (EBER-1) transcripts. Forty-five cases (82%) had classic HL (cHL), and ten cases (18%) had nodular lymphocyte predominant HL (NLPHL), with each group expressing its typical phenotype. LMP-1 stains were positive in 63% and 0% of cHL and NLPHL cases, respectively. EBER-positive Reed-Sternberg cells and variants were also present in 62% and 0% of each group, respectively. The cHL cases showed variable EBER positivity: nodular sclerosis, 58%; mixed cellularity, 100%; lymphocyte depletion, 100%; and unclassifiable, 67%. Our findings are similar to those from other developing countries and point towards a pathogenic role of EBV in cHL.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Epstein–Barr virus and Hodgkin’s lymphoma in Cairo, Egypt

et al. 2010

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“…In situ hybridization study was done to detect EBV-encoded RNA 1 using a PCR-derived digoxigenin-labeled DNA probe (25,26). The test for nucleotide integrity was done by the use of the RNA-positive control probe (Ventana Medical System, Inc.).…”

Section: Methodsmentioning

confidence: 99%

Distribution Patterns of Dendritic Cells and T Cells in Diffuse Large B-Cell Lymphomas Correlate with Prognoses

Chang

Huang

Jones

et al. 2007

Clinical Cancer Research

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Purpose: Diffuse large B-cell lymphoma (DLBCL), the most common subtype of non-Hodgkin's lymphomas, accounts for 30% to 40% of all lymphoma cases. However, long-term survival by current chemotherapy was achieved in only 40% of patients, warranting the development of novel therapeutic strategies including T-cell immunotherapy. However, the level of baseline immune activation in DLBCL is unclear. Experimental Design: The density and distribution of dendritic cells and T cells in 48 cases of primary DLBCL was evaluated by immunohistochemistry. Results: Increased numbers of intratumoral CD1a + dendritic cells and increased S100 + cells and CD45RO + T cells around the edges of the tumors were seen in 10 of 48 (21%), 9 of 48 (19%), and 10 of 48 (21%) cases and these were correlated with a favorable prognosis (P = 0.015; P = 0.070, and P = 0.017, respectively), along with increased granzyme B + T cells in tumor beds (P = 0.013). Increased peritumoral T cells were correlated with tumor expression of HLA-DR (r = 0.446; P = 0.002). Extranodal lymphomas showed fewer tumor-associated CD45RO + Tcells (r = -0.407; P = 0.001) and less conspicuous dendritic cell infiltrates. Conclusions: In DLBCL, the presence of baseline antitumor immune response is associated with favorable clinical outcome, and thus adjuvant T-cell immunotherapy may further boost treatment responses.

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“…Patients who developed infectious mononucleosis in adulthood had a threefold greater risk of developing HL compared with those who did not [20]. EBV is found in approximately 40% of cases, more often in the mixed cellularity and lymphocyte depletion subtype [21]. EBV þ HRS cells express EBV nuclear antigen 1 (EBNA1) and latent membrane proteins 1 and 2A (LMP1, LMP2A).…”

Section: Genetic Aberrationsmentioning

confidence: 99%