Epstein-Barr Virus Nuclear Antigen 1 Recruits Cyclophilin A to Facilitate the Replication of Viral DNA Genome

Xin, Shuyu; Du, Shujuan; Liu, Lingzhi; Xie, Yan; Zuo, Lielian; Yang, Jing; Hu, Jingjin; Yue, Wenxing; Zhang, Jing; Cao, Pengfei; Zhu, Fanxiu; Lu, Jianhong

doi:10.3389/fmicb.2019.02879

Cited by 12 publications

(14 citation statements)

References 63 publications

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“…USP7 has been related to many diseases, such as lung cancer, cervical cancer, herpes simplex virus, and nasopharyngeal carcinoma by Epstein-Bar virus (EBV) [114][115][116][117]. USP7 plays an important role in tumorigenesis and progression by deubiquitinating a variety of tumor regulatory molecules [95] and is a promising target for the development of lead compounds.…”

Section: Usp7 a Conformational Rearrangement Of The Catalytic Triadmentioning

confidence: 99%

Molecular Mechanisms of DUBs Regulation in Signaling and Disease

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2021

IJMS

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The large family of deubiquitinating enzymes (DUBs) are involved in the regulation of a plethora of processes carried out inside the cell by protein ubiquitination. Ubiquitination is a basic pathway responsible for the correct protein homeostasis in the cell, which could regulate the fate of proteins through the ubiquitin–proteasome system (UPS). In this review we will focus on recent advances on the molecular mechanisms and specificities found for some types of DUBs enzymes, highlighting illustrative examples in which the regulatory mechanism for DUBs has been understood in depth at the molecular level by structural biology. DUB proteases are responsible for cleavage and regulation of the multiple types of ubiquitin linkages that can be synthesized inside the cell, known as the ubiquitin-code, which are tightly connected to specific substrate functions. We will display some strategies carried out by members of different DUB families to provide specificity on the cleavage of particular ubiquitin linkages. Finally, we will also discuss recent progress made for the development of drug compounds targeting DUB proteases, which are usually correlated to the progress of many pathologies such as cancer and neurodegenerative diseases.

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Section: Usp7 a Conformational Rearrangement Of The Catalytic Triadmentioning

confidence: 99%

Molecular Mechanisms of DUBs Regulation in Signaling and Disease

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2021

IJMS

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“…Soil texture was the most important attribute underpinning changes in soil bacterial taxonomic diversity and composition. Soil texture shapes the microhabitats for bacteria and other members of the soil microbial community [80]. Seaton et al [81] found that clay and silt particles were more important for soil bacterial composition than sand in a range of habitats including arable, improved, and unimproved grassland, broadleaved and coniferous woodland, and heathland.…”

Section: Changes In Bacterial Taxonomic Composition With Land Use and Depthmentioning

confidence: 99%

Soil Bacterial Community Responds to Land-Use Change in Riparian Ecosystems

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Kasel

et al. 2021

Forests

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Riparian forests were frequently cleared and converted to agricultural pastures, but in recent times these pastures are often revegetated in an effort to return riparian forest structure and function. We tested if there is a change in the soil bacterial taxonomy and function in areas of riparian forest cleared for agricultural pasture then revegetated, and if soil bacterial taxonomy and function is related to vegetation and soil physicochemical properties. The study was conducted in six riparian areas in south-eastern Australia, each comprising of three land-use types: remnant riparian forest, cleared forest converted to pasture, and revegetated pastures. We surveyed three strata of vegetation and sampled surface soil and subsoil to characterize physicochemical properties. Taxonomic and functional composition of soil bacterial communities were assessed using 16S rRNA gene sequences and community level physiological profiles, respectively. Few soil physiochemical properties differed with land use despite distinct vegetation in pasture relative to remnant and revegetated areas. Overall bacterial taxonomic and functional composition of remnant forest and revegetated soils were distinct from pasture soil. Land-use differences were not consistent for all bacterial phyla, as Acidobacteria were more abundant in remnant soils; conversely, Actinobacteria were more abundant in pasture soils. Overall, bacterial metabolic activity and soil carbon and nitrogen content decreased with soil depth, while bacterial metabolic diversity and evenness increased with soil depth. Soil bacterial taxonomic composition was related to soil texture and soil fertility, but functional composition was only related to soil texture. Our results suggest that the conversion of riparian forests to pasture is associated with significant changes in the soil bacterial community, and that revegetation contributes to reversing such changes. Nevertheless, the observed changes in bacterial community composition (taxonomic and functional) were not directly related to changes in vegetation but were more closely related to soil attributes.

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“…Epstein-Barr virus (EBV) can exist in most people in a latent state, inseparable from its ability to escape and destroy the innate immune system ( Xin et al, 2019 ; Dang et al, 2021 ). EBV oncoprotein LMP1 promotes the expression of IRF7, which has been implicated in IFNs signaling in previous studies ( Ning et al, 2005 ).…”

Section: Cellular Dubs Exploited By Viruses To Support Self-replication and Immune Evasionmentioning

confidence: 99%

Cellular Deubiquitylating Enzyme: A Regulatory Factor of Antiviral Innate Immunity

et al. 2021

Self Cite

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Deubiquitylating enzymes (DUBs) are proteases that crack the ubiquitin code from ubiquitylated substrates to reverse the fate of substrate proteins. Recently, DUBs have been found to mediate various cellular biological functions, including antiviral innate immune response mediated by pattern-recognition receptors (PRRs) and NLR Family pyrin domain containing 3 (NLRP3) inflammasomes. So far, many DUBs have been identified to exert a distinct function in fine-tuning antiviral innate immunity and are utilized by viruses for immune evasion. Here, the recent advances in the regulation of antiviral responses by DUBs are reviewed. We also discussed the DUBs-mediated interaction between the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and antiviral innate immunity. The understanding of the mechanisms on antiviral innate immunity regulated by DUBs may provide therapeutic opportunities for viral infection.

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Epstein-Barr Virus Nuclear Antigen 1 Recruits Cyclophilin A to Facilitate the Replication of Viral DNA Genome

Cited by 12 publications

References 63 publications

Molecular Mechanisms of DUBs Regulation in Signaling and Disease

Molecular Mechanisms of DUBs Regulation in Signaling and Disease

Soil Bacterial Community Responds to Land-Use Change in Riparian Ecosystems

Cellular Deubiquitylating Enzyme: A Regulatory Factor of Antiviral Innate Immunity

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