Epstein-Barr Virus Viral Processivity Factor EA-D Facilitates Virus Lytic Replication by Inducing Poly(ADP-Ribose) Polymerase 1 Degradation

Abstract

PARP1 acts as a negative regulator of lytic replication in EBV. To successfully enter the reactivation cycle, EBV has developed multiple strategies to counteract the host’s repressive mechanisms.

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“…An additional function of BMRF1 in the degradation of PARP1 through a proteosome-dependent mechanism was identified by aligning to the function of other viral processivity factors (PF) such as KSHV PF-8 and MHV68 mPF [ 112 , 113 ]. Since PARP1 is a repressive host protein that negatively regulates lytic replication in gamma-herpesviruses, degradation of PARP1 is a viral strategy to facilitate lytic replication and inhibit DDR [ 114 , 115 ].…”