Equilibrium between tri‐ and tetra‐coordinate chalcogenuranes is critical for cysteine protease inhibition

Silva, Gabriela Dias da; Cunha, Rodrigo L. O. R.; Coutinho-Neto, Maurı́cio D.

doi:10.1002/jcc.26535

J Comput Chem

2021

DOI: 10.1002/jcc.26535

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Equilibrium between tri‐ and tetra‐coordinate chalcogenuranes is critical for cysteine protease inhibition

Gabriela Dias da Silva

Rodrigo L. O. R. Cunha

Maurı́cio D. Coutinho-Neto

Abstract: File list (4) download file view on ChemRxiv journal_of_computational_chemistry_template.pdf (670.25 KiB) download file view on ChemRxiv gif-acido.gif (617.92 KiB) download file view on ChemRxiv gif-basico.gif (562.39 KiB) download file view on ChemRxiv supporting_information-novo-sem-coordenadas.pdf (592.42 KiB)

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Density Functional Theory (DFT) and Time‐Dependent DFT (TDDFT) Studies of Porphyrin Adsorption on Graphene: Insights on the Effect of Substituents and Central Metal on Adsorption Energies

Gara,

Morales‐García,

Arfaoui

et al. 2024

J Comput Chem

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Combining metalloporphyrins (MPr) and graphene constitutes key composites in the development of photovoltaic devices. Here, we focus on the analysis of the properties of metalloporphyrins/graphene systems by means of the density functional theory (DFT) and its time‐dependent (TDDFT) version, focusing on the ground and singlet excited states. Our benchmark analysis concludes that ωB97XD density functional combined with 6‐31G(d)/Def2‐TZVP basis set is a better‐suited method for simulating accurate MPr adsorption on graphene. It is shown that a reduced atomic model where the external organic shell of the structure is removed provides the same resulting optoelectronic properties of the original model, constituting an important speed‐up of the calculations when studying porphyrins‐derived molecules. We observe that ZnPr provides the highest light harvesting efficiency (LHE) value. In addition, we find out that the adsorption energy increases monotonically with the size of the graphene flake and the highest stability involves the use of graphene comprising above 500 atoms. Besides, CdPr and HgPr keep their properties as photosensitizers when they are bonded to graphene and show promising values in terms of LHE emerging as suitable solar energy harvesters.

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Density Functional Theory (DFT) and Time‐Dependent DFT (TDDFT) Studies of Porphyrin Adsorption on Graphene: Insights on the Effect of Substituents and Central Metal on Adsorption Energies

Gara,

Morales‐García,

Arfaoui

et al. 2024

J Comput Chem

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show abstract

Crystal structures and docking studies in cathepsin S of bioactive 1,3‐diphenyl‐4‐(trichloro‐λ4‐tellanyl)but‐2‐en‐1‐one derivatives

Maganhi

Caracelli

Zukerman-Schpector

et al. 2021

Journal of Molecular Structure

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Equilibrium between tri‐ and tetra‐coordinate chalcogenuranes is critical for cysteine protease inhibition

Cited by 2 publications

References 80 publications

Density Functional Theory (DFT) and Time‐Dependent DFT (TDDFT) Studies of Porphyrin Adsorption on Graphene: Insights on the Effect of Substituents and Central Metal on Adsorption Energies

Density Functional Theory (DFT) and Time‐Dependent DFT (TDDFT) Studies of Porphyrin Adsorption on Graphene: Insights on the Effect of Substituents and Central Metal on Adsorption Energies

Crystal structures and docking studies in cathepsin S of bioactive 1,3‐diphenyl‐4‐(trichloro‐λ4‐tellanyl)but‐2‐en‐1‐one derivatives

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