Equilibrium binding constants and facile dissociation of novel serum albumin-dicyanoaurate(I) complexes

The anticancer effect related to disturbances in redox balance on Caco-2 cells caused by an alkynyl gold(I) complex

“…2B). The value obtained in the experiment for the binding constant at room temperature of 7.21·10 4 M − 1 is notably higher than the measured in the interaction of cisplatin with HSA 8.52·10 2 M − 1 [48] and in related alkyne gold(I) derivatives (values ranging from 10 1 to 10 3 ) [49], but is next to the values found in the anion [Au(CN) 2 ] − [50] and in gold(III) complexes (10 4 -10 5 ) [51,52], although significantly smaller than the observed in gold nanoparticles (around 10 8 -10 10 ) [53,54]. The experimental value of K b of 7.21·10 4 M − 1 is in accordance with a significant interaction with BSA, which would allow the biodistribution of the drug in plasma.…”

A convenient approach to amphiphilic hyperbranched polymers with thioether shell for the preparation and stabilization of coinage metal (Cu, Ag, Au) nanoparticles

“…On addition of HAuCl 4 , initially insoluble in toluene, to a solution of 3 in toluene, a homogenous reddish orange solution was obtained, indicating the loading of Au 3+ into polymer 3 . Gold salts are known to bind to thioether function with a constant of K Au‐thioether = 5 × 10 4 . Addition of NaBH 4 resulted in a color change of the solution to violet, which supports the formation of Au 0 NPs that are partially aggregated.…”

Applications of NMR spectroscopy in understanding the gold biochemistry

“…[Au(CN) 2 ] − has been identified as a common metabolite of the gold drugs in the blood and urine of chrysotherapy patients [63]. [24,31,61,62,64]. Graham et al investigated the effect of cyanide on (Autm) n activation.…”

“…Tobacco smoking is known to increase the concentrations of gold in red blood cells in patients treated with (Autm) n [66,67]. Cyanide acts as a shuttle to carry gold into red blood cells, because of inhalation of HCN from tobacco smoke [64].…”

“…Although, the concentration of cyanide is very low in RBCs (0.3-1 µM) [77,78], there is a high formation constant between cyanide and gold(I), ∼10 39 [79] and therefore bis(glutathione)gold(I) and dicyanogold(I) are likely to be found in RBCs. The mechanism by which [Au(CN) 2 ] − is transported through the cell membrane is still a subject of current research [62,64,80]. However, the most convincing mechanism is the one in which gold(I) complexes undergo ligand exchange reactions to bind to sulfhydryl groups immobilized on or in the membrane.…”