Equilibrium vesicles: fact or fiction?

Laughlin, Robert G.

doi:10.1016/s0927-7757(97)03899-5

Cited by 101 publications

(83 citation statements)

References 48 publications

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“…This observation was also offered by Laughlin as the explanation for the observed vesicles [94]. Almgren also reports QLS measurements of mixtures of CTAB and SOS at a given mixing ratio that show an increase in mean radius with time, which agrees with our results at that mixing ratio [31].…”

Section: Equilibrium?supporting

confidence: 91%

“…Whether or not the vesicles are the equilibrium state of aggregation has been explored by several authors [46,94,95], all of whom conclude for various reasons that the vesicles are unstable with respect to a lamellar phase. A corollary argument is that the vesicles that are observed are the consequence of shear forces, which might be vanishingly small, that disrupt the stacked bilayers of a lamellar phase.…”

Section: Equilibrium?mentioning

confidence: 99%

See 1 more Smart Citation

Phase Behavior and Microstructure in Aqueous Mixtures of Cationic and Anionic Surfactants

Kaler¹,

Herrington²,

Iampietro³

et al. 2004

Surfactant Science

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][ [Page No. 290] {Books}4380-Abe/4380-Abe-009.3d 4380-Abe SYNOPSISMixtures of anionic and cationic surfactants in water display interesting phase behavior and a range of microstructures, including small micelles, rod-like micelles, lamellar phases and vesicles. This chapter reviews the properties of these mixtures with a focus on the experimental and theoretical aspects of vesicle formation and stability.

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Section: Equilibrium?supporting

confidence: 91%

Section: Equilibrium?mentioning

confidence: 99%

Phase Behavior and Microstructure in Aqueous Mixtures of Cationic and Anionic Surfactants

Kaler¹,

Herrington²,

Iampietro³

et al. 2004

Surfactant Science

View full text Add to dashboard Cite

show abstract

“…Thus, catanionic vesicles have great potential as drug carriers. However, the phase behavior of catanionic mixtures possessing several components is complicated for analysis 18 , although simplified ternary diagrams cationic surfactant, anionic surfactant, and water have often been adopted. In addition, the vesicle domains usually exist in the excess cationic or anionic surfactant region and the low-concentration region, whereas precipitation occurs under equimolar conditions 4,5,7 .…”

Section: Introductionmentioning

confidence: 99%

Recent Strategies in the Development of Catanionic Vesicles

Kuo

Chang

2016

J. Oleo Sci.

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“…[24,[29][30][31] In recent decades, polydispersity and size distribution of equilibrium unilamellar vesicles has been extensively studied both experimentally and theoretically. In experimental works, effects of ionic strength, amphiphile concentration, and lipid properties (e.g., bending rigidity) on vesicle sizes under specific conditions were reported.…”

Section: Introductionmentioning

confidence: 99%

Stability of Uni‐ and Multillamellar Spherical Vesicles

2011

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Lipid molecules in water form uni- or multilamellar vesicles in polydisperse form. Herein, we present energetic considerations for their equilibrium morphological organization. Our formulation provides elemental energy diagrams, which explain the polydispersity and account for the structural diversity. These energy diagrams describe the ranges of core radius (r(c)) and number of lamellae (N) that result in the formation of stable vesicles under specific conditions, thus providing prescriptions for the design of vesicles tailored for specific properties, including stability, cargo capacity, and resistance to deformation by osmotic stress. We deduced key design criteria as follows: 1) designing highly stable unilamellar vesicles requires low bending rigidity lipids and dimensions exceeding a few hundred nm in radii; 2) very large unilamellar vesicles (r(c)>several tens of microns) are not stable for typical lipids; lipids with higher bending rigidity are required; 3) the distribution of the stable size of vesicles is proportional to the bending rigidity; 4) for the case of multilamellar vesicles, vesicles with more than a few hundred layers usually exhibit greater structural integrity than those with lower degrees of lamellarity, especially when the core radii are small (<100 nm); 5) for osmotically stressed vesicles, the energy contributed by even a small concentration gradient (>mM) is the most dominant factor in the free energy, suggesting active response by vesicles (e.g., poration) to release osmotic stress; and 6) vesicles with a core radius of a few hundred nm and more than hundred lamellae are more resistant to deformation by osmotic stress, thus making them more suited to applications involving osmotic pressure gradients, such as in drug delivery.

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Equilibrium vesicles: fact or fiction?

Cited by 101 publications

References 48 publications

Phase Behavior and Microstructure in Aqueous Mixtures of Cationic and Anionic Surfactants

Phase Behavior and Microstructure in Aqueous Mixtures of Cationic and Anionic Surfactants

Recent Strategies in the Development of Catanionic Vesicles

Stability of Uni‐ and Multillamellar Spherical Vesicles

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