Equimolar Hg-Se Complex Binds to Selenoprotein P

Yoneda, Shinji; Suzuki, Kazuo

doi:10.1006/bbrc.1996.6036

Cited by 163 publications

(67 citation statements)

References 14 publications

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“…Many studies present a positive linear correlation between Hg and Se (Koeman et al 1973;Kosta et al 1975;Luten et al 1980). From an experiment based on the addition of the 82 Se isotope and HgCl 2 in rat blood, Yoneda and Suzuki (1997) proposed the formation of an equimolar Hg-Se complex binding to selenoprotein P, which seems to support the observation of the positive linear relationship. However Figs.…”

Section: Data Treatment-mentioning

confidence: 90%

Antagonistic effect of selenium on mercury assimilation by fish populations near Sudbury metal smelters?

Chen

Belzile

Gunn

2001

Limnology & Oceanography

102

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Abstract-In this study, the concentrations of Se and Hg were determined in perch (Perca flavescens) and walleye (Stizosedion vitreum) muscle from nine lakes that varied in distance (4-204 km) from the metal smelters of Sudbury, Canada. Significant inverse relationships between Se and Hg in perch (r 2 ϭ 0.79, P Ͻ 0.05) and walleye tissue (r 2 ϭ 0.97, P Ͻ 0.01) were detected, which suggests a strong antagonistic effect of Se on Hg assimilation by these fish species. Concentration of Hg decreased exponentially with an increase of Se in fish muscle. Total dissolved Se concentrations of lake water declined with distance from smelters and were correlated to Se in perch (r 2 ϭ 0.75, P Ͻ 0.05) and walleye (r 2 ϭ 0.95, P Ͻ 0.01). Hg concentrations in the fish from lakes near the smelter were well below average values in fish in boreal shield lakes of this region.

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Section: Data Treatment-mentioning

confidence: 90%

Antagonistic effect of selenium on mercury assimilation by fish populations near Sudbury metal smelters?

Chen

Belzile

Gunn

2001

Limnology & Oceanography

102

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“…SelP forms higher order multimeric complexes with inorganic mercury and free selenium, and, although it has 10 selenocysteines, and 17 cysteine residues, it has been estimated that a single SelP molecule can bind more than 100 molecules of mercury [144]. Thus SelP not only serves as a selenium reservoir to support selenoprotein synthesis, but may also function as a high-affinity binding site for mercury, protecting other selenoproteins from its toxic effect.…”

Section: A Mechanistic Model Of Mercury Toxicitymentioning

confidence: 99%

Does Inorganic Mercury Play a Role in Alzheimer's Disease? A Systematic Review and an Integrated Molecular Mechanism

Mutter¹,

Curth

Naumann³

et al. 2010

JAD

147

113

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Abstract. Mercury is one of the most toxic substances known to humans. It has been introduced into the human environment and has also been widely used in medicine. Since circumstantial evidence exists that the pathology of Alzheimer's disease (AD) might be in part caused or exacerbated by inorganic mercury, we conducted a systematic review using a comprehensive search strategy. Studies were screened according to a pre-defined protocol. Two reviewers extracted relevant data independent of each other. One thousand and forty one references were scrutinized, and 106 studies fulfilled the inclusion criteria. Most studies were case control or comparative cohort studies. Thirty-two studies, out of 40 testing memory in individuals exposed to inorganic mercury, found significant memory deficits. Some autopsy studies found increased mercury levels in brain tissues of AD patients. Measurements of mercury levels in blood, urine, hair, nails, and cerebrospinal fluid were inconsistent. In vitro models showed that inorganic mercury reproduces all pathological changes seen in AD, and in animal models inorganic mercury produced changes that are similar to those seen in AD. Its high affinity for selenium and selenoproteins suggests that inorganic mercury may promote neurodegenerative disorders via disruption of redox regulation. Inorganic mercury may play a role as a co-factor in the development of AD. It may also increase the pathological influence of other metals. Our mechanistic model describes potential causal pathways. As the single most effective public health primary preventive measure, industrial, and medical usage of mercury should be eliminated as soon as possible.

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“…The biomineral HgSe is assumed to be an inert end-product of the detoxification pathway (Martoja and Berry, 1980). The formation of an equimolar (HgSe) n polymer that is bound to the plasma selenoprotein P (Sel P) was found in the bloodstream and identified (Yoneda and Suzuki, 1997). This (HgSe)eSel P is thought to also be a precursor of the crystalline HgSe (Ikemoto et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Blood dynamics of mercury and selenium in northern elephant seals during the lactation period

Habran

Debier

Crocker

et al. 2011

Environmental Pollution

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a b s t r a c tThe effects of reproduction and maternal investment (i.e., milk transfer) on trace element levels remain poorly understood in marine mammals. We examined the blood dynamics of mercury (Hg) and selenium (Se) during lactation in the northern elephant seal (Mirounga angustirostris), a top predator from the North Pacific Ocean. Total Hg and Se levels were measured in whole blood and milk of 10 motherepup pairs on days 5 and 22 of lactation. Both Hg and Se were transferred to offspring through the milk. Results suggested that the maternal transfer of Se was prominent during lactation, whereas the Hg transfer was larger during gestation. The lactation period affected Hg and Se levels in the blood of elephant seal mothers and pups. Physiological processes and their relationship to body condition should be considered carefully when interpreting trace element levels in the framework of biomonitoring.

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Equimolar Hg-Se Complex Binds to Selenoprotein P

Cited by 163 publications

References 14 publications

Antagonistic effect of selenium on mercury assimilation by fish populations near Sudbury metal smelters?

Antagonistic effect of selenium on mercury assimilation by fish populations near Sudbury metal smelters?

Does Inorganic Mercury Play a Role in Alzheimer's Disease? A Systematic Review and an Integrated Molecular Mechanism

Blood dynamics of mercury and selenium in northern elephant seals during the lactation period

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