Equipment for drug release testing of medicated chewing gums

Kvist, L C; Andersson, Sven Börje; Berglund, Johan; Wennergren, Bo; Fors, Susan

doi:10.1016/s0731-7085(99)00307-6

Cited by 26 publications

(19 citation statements)

References 2 publications

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“…Aliquots of 1 ml were withdrawn from each time point from the chamber at 0, 5, 10, 15, 30 and 60 min during the in vitro releasing procedure. The samples were diluted for analyzing the drug concentrations in the test medium (Kvist et al 2000).…”

Section: Methodsmentioning

confidence: 99%

The development and in vitro evaluation of benzydamine hydrochloride medicated chewing gum formulations

Akbal¹,

Cevher²,

Araman³

2017

Istanbul J Pharm

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The objective of this study was to develop a chewing gum formulation for benzydamine hydrochloride (BN) and evaluate the effect of different co-compression agents on physicochemical parameters and in vitro drug release profile. BN has been utilized in symptomatic treatment for pain and irritations of the mouth and throat. Chewing gum formulations of BN were produced using direct compression method. In fabricated chewing gums, except pharmacopeia analysis, physical and structural analysis like thickness, weight variation, elasticity and compressibility were evaluated. The release of BN from the gum was studied using the chewing apparatus which have been designed for procuring the release of BN from the chewing gum.The quantity of BN present in the chewing gum and the release medium were quantified by spectrophotometric method. Gum formulations showed promising in vitro release profiles, in which 80-90% BN was released in a sustained manner over 20 min of chewing time. In addition, it was observed that the drug release was fitted into matrix diffusion kinetic and revealed a non-Fickian drug release mechanism. This study suggests that BN in a gum formulation is a suitable dosage form for the delivery in the oral cavity, thereby and serving as an instant analgesic.

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Section: Methodsmentioning

confidence: 99%

The development and in vitro evaluation of benzydamine hydrochloride medicated chewing gum formulations

Akbal¹,

Cevher²,

Araman³

2017

Istanbul J Pharm

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“…The influences of different operational parameters of the chewing gum apparatus on drug release have been carefully investigated (23).…”

Section: Apparatus II Alternative Chewing Gum Apparatus Noncompendimentioning

confidence: 99%

“…Both the apparatus described have been well studied and reported in the literature (15)(16)(17)(18)(22)(23)(24)(25). The results show that the apparatus can provide strong mechanical forces that influence drug release and can prove to be a useful tool for drug release testing of medicated chewing gums both in quality control as well as in product development.…”

Section: General Comments About Apparatus I and Apparatus Iimentioning

confidence: 99%

Product Performance Test for Medicated Chewing Gums

Gajendran¹,

Kraemer²,

Knudsen³

2010

Dissolution Technol.

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The nature and type of performance tests used to characterize dosage forms administered to the oral cavity differ significantly and thus demand different release testing apparatus. For many dosage forms given orally but not limited to muco-adhesive buccal tablets, chewable tablets, and sublingual preparations, product performance tests are adapted from existing procedures and are well characterized in the United States Pharmacopeia (USP). Unlike chewable tablets, medicated gums are not supposed to be swallowed and may be removed from the site of application without resort to invasive means. Moreover, medicated gums require the active and continuous masticatory activities for activation and continuation of drug release. Medicated chewing gums are dosage forms given orally for both local and therapeutic effect, and no performance test has been indicated for medicated chewing gums in USP. This Stimuli article outlines the importance and rationale of in vitro drug release testing and the product quality tests used during the development of medicated chewing gums and their quality control for market release.

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“…cigarette butt [7], chewing gum [8], pharmaceuticals [9], nasal powder [10], dietary nicotine [11], fertilizer [12] as well as nicotine and its metabolite in various biological samples like plasma [13][14][15][16], urine [14], hair [17,18], saliva [11], meconium [19], cutaneous nicotine [20] and milk [21] leaving apart experimental animals and animal products [22][23][24]. Analytical techniques for the determination of nicotine in these samples includes enzyme linked immunoassay and radio immunoassay [25,26], gas chromatography [9], gas chromatography-mass spectrometry [10,11,24], high performance liquid chromatography (HPLC) coupled with ultraviolet detector [6,12,14,15,18,[20][21][22][23][24], diode array detection [18], electrochemical detector [17] and mass spectrometry [7,11,13,16,19].…”

Section: Introductionmentioning

confidence: 99%