Er: YAG Laser Device for Taking Blood Samples

Cabrera, José Luis Perelló; Ponce, L.; Arronte, M.; Flores, T.; Lambert, B.; Pena, Adrian

doi:10.3844/ojbsci.2008.15.18

Cited by 3 publications

(3 citation statements)

References 6 publications

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“…To address these problems, needleless laser lancets that are based on pulsed lasers have been studied. In general, a needleless laser lancet contains a pulsed laser with a central wavelength of 2940 nm and a form that can control the output according to the skin condition of the patient 9 . In a previous study, a needleless laser lancet and a conventional lancet were evaluated for puncture pain; the needleless laser lancet showed a significant reduction in pain compared with the conventional lancet.…”

Section: Introductionmentioning

confidence: 99%

Analysis of penetration depth and healing process of a needleless laser lancet using swept‐source optical coherence tomography

et al. 2022

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Background and Objectives: Needleless laser lancets have been used to reduce needle pain in people who undertake self-monitoring of blood glucose (SMBG). Although clinical trials have been conducted to understand the degree of pain associated with the developed laser blood sampling device, it is only judged by the patients' subjective judgment. This study aimed to analyze the performance and healing process of a needleless laser lancet. In particular, the penetration depth and healing process of a conventional lancet and a needleless laser lancet were quantitatively analyzed using a swept-source optical coherence tomography (SS-OCT) system. Materials and Methods: To reduce unnecessary animal sacrifice, pig skin was used to establish and set the conditions for needleless laser lancets (wavelength of 2.94 μm; LMT-5000; Lameditech), and the penetration depth and healing process were quantitatively assessed at 0, 6, 9, and 16 h after laser (energy, 150-270 mJ in stages; voltage, 7.4 V dc ; pulse width, approximately 200 microsecond) irradiation using 7-week-old male BALB/c nude mice. The penetration depth and healing process were measured using homemade SS-OCT, and histopathological examination was performed to observe the healing process. Results: Four 7-week-old male BALB/c nude mice were tested at intensity levels of 1-3 using a needleless laser lancet and compared with the experimental values using a conventional lancet. After the lancet test, the diameter and depth of the puncture were measured using SS-OCT and the healing process was confirmed using SS-OCT and pathological slides. The puncture diameter of the needleless laser lancet was about 0.5 mm regardless of the level. In addition, the average depths at Levels 1, 2, and 3 of the measured needleless laser lancet were approximately 1.05, 1.18, and 1.52 mm, respectively, and the last common lancet was approximately 0.9 mm. In addition, the healing process of the needleless laser lancet and conventional lancet was confirmed through the SS-OCT system. Conclusion: After using the needleless laser lancet, quantitative indicators such as the diameter of puncture, penetration depth, and healing process were confirmed through two-dimensional and three-dimensional images of the homemade SS-OCT system and microscopic imaging of pathological slides.

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Section: Introductionmentioning

confidence: 99%

Analysis of penetration depth and healing process of a needleless laser lancet using swept‐source optical coherence tomography

et al. 2022

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“…10,12 The Er:YAG laser energy is strongly absorbed by water due to high absorption of light with a wavelength of 2940 μm and can cause selective ablation at a very limited depth in skin tissue with minimal thermal damage. 13 Pulse duration is an important factor in the generation of thermal effects; [13][14][15] with the generation of pulse energy in less time than 1/10,000 s, LMT-1000 minimized thermal damage. A laser lancing device has a penetration depth lower than that of a lancet, and this has been postulated to be a cause of less pain.…”

Section: Discussionmentioning

confidence: 99%

Comparison between a laser lancing device and lancet for capillary blood sampling, capillary blood hemoglobin measurement, and blood typing

et al. 2021

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Background: Blood donor screening includes tests using capillary blood, which is usually obtained by finger pricking using a lancet; however, the lancet has some shortcomings, such as skin puncture pain and needle stick injury.Recently, laser lancing devices for finger-prick sampling have been developed. We compared capillary blood Hb (cHb) levels and blood typing results obtained using a laser lancing device with those obtained using a lancet. Study design and methods: cHb levels, blood typing results, and skin puncture pain scores were assessed in 191 participants. Finger-prick sampling was performed using LMT-1000 (LaMeditech, Seoul, Korea) and a lancet on the same finger on different hands. Paired venous Hb (vHb) levels were assessed in 103 participants using an automated hematology analyzer and compared with the cHb levels obtained using both lancing devices. Results:The paired cHb results obtained with the laser lancing device and lancet showed a strong correlation (r = 0.927, p < .001) without any significant difference (p = .113) and a substantial agreement (κ = 0.654) for the identification of participants with a low Hb level (<12.5 g/dl). cHb levels were significantly higher than vHb levels with both lancing devices (mean differences: 0.27-0.43 g/dl). The results of blood typing using the laser lancing device showed 100% accuracy. Use of the laser lancing device showed significantly lower skin puncture pain scores (p < .001). Conclusion: Use of a laser lancing device for capillary Hb measurement and blood typing showed accurate results, with significantly reduced skin puncture pain. Laser lancing devices could be feasible for donor screening tests.

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“…Moreover, this laser penetrates to a more shallow depth compared with Ho:YAG and Nd:YAG lasers, diminishing the resulting pain. 11 In addition, using short pulses and a focus lens generates smaller wounds compared with those in°icted using traditional lancets. However, excessively small holes may not yield su±cient blood collection.…”

Section: Introductionmentioning

confidence: 99%

Accurate laser skin perforation technique aimed at promoting bleeding and reducing pain

Chang

Lin

Huang

2015

J. Innov. Opt. Health Sci.

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Laser skin perforation is an e®ective and promising technique for use in blood collection. In this study, the relation between the perforation pro¯le of skin and laser irradiation at various energies is discussed. Increasing laser energy does not uniformly expand the size and depth of a hole because the shallow depth of¯eld (DOF) of the focused light primarily concentrates energy on the skin surface. In practice, the hole gradually transforms from a semielliptical shape to an upsidedown avocado shape as the laser energy increases. This phenomenon can increase the amount of bleeding and reduce pain. The¯ndings support the feasibility of developing an accurate laser skin perforation method.

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Er: YAG Laser Device for Taking Blood Samples

Cited by 3 publications

References 6 publications

Analysis of penetration depth and healing process of a needleless laser lancet using swept‐source optical coherence tomography

Analysis of penetration depth and healing process of a needleless laser lancet using swept‐source optical coherence tomography

Comparison between a laser lancing device and lancet for capillary blood sampling, capillary blood hemoglobin measurement, and blood typing

Accurate laser skin perforation technique aimed at promoting bleeding and reducing pain

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