Eradication of Helicobactor pylori May Trigger Onset of Type 1 Diabetes

Tada, Ai; Komiya, Naoko; Shimada, Akira; Katsuki, Tsutomu; Oikawa, Yoichi; Itoh, Hiroshi

doi:10.1196/annals.1447.001

Cited by 3 publications

(5 citation statements)

References 4 publications

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“…3 However, another case report from Japan indicated that the eradication of H. pylori might trigger the onset of type 1 diabetes. 4 Although our study is limited by the fact that it is a retrospective analysis from one center with a small number of subjects, the present findings suggest that eradication therapy for H. pylori does not, at least profoundly, affect glycemic control in Japanese subjects with type 2 diabetes. Further investigation is needed to determine whether autoantibodies against insulin or islet cells possibly triggered by H. pylori infection might be an irreversible process.…”

Section: Discussionmentioning

confidence: 52%

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The Eradication of Helicobacter pylori does not Affect Glycemic Control in Japanese Subjects with Type 2 Diabetes

et al. 2013

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Since infection with Helicobacter pylori has been suggested to play a pathogenic role in diabetes mellitus, we investigated whether eradication therapy for H. pylori might affect glycemic control in Japanese subjects with type 2 diabetes. A total of 72 subjects (55 males, 17 females; aged 63.7 years) with type 2 diabetes who received eradication therapy for H. pylori were included. The change of their blood glycosylated hemoglobin (A1C) levels 3 months before (−3 m) the H. pylori eradication, as well as 3 months (3 m) and 6 months (6 m) after were evaluated. Their A1C levels did not show any significant change after therapy {6.9 [0.1]% (−3 m) to 7.0 [0.1]% (3 m); P = 0.3, 7.0 [0.1] (6 m); P = 0.3}. Our findings suggest that the eradication therapy for H. pylori does not, at least profoundly, affect glycemic control in Japanese subjects with type 2 diabetes.

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Section: Discussionmentioning

confidence: 52%

“…3 However, another case report from Japan indicated that the eradication of H. pylori might trigger the onset of type 1 diabetes. 4…”

Section: Discussionmentioning

confidence: 99%

The Eradication of Helicobacter pylori does not Affect Glycemic Control in Japanese Subjects with Type 2 Diabetes

et al. 2013

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“…Dore et al found that Hp frequency was lower in a small group of 12–19-year-old adolescents with T1DM compared to age-matched controls (9.0 vs. 25.0%); however, statistical significance was absent [22]. In 2008, Tada et al [23] speculated that eradicating Hp triggered T1DM in an adult by a case report. On the other hand, some authors reported that the Hp infection frequency in T1DM did not differ from the infection rate observed in the control groups by 13 C urea breath test (UBT) or serology [12‒15].…”

Section: Discussionmentioning

confidence: 99%

“…Helicobacter pylori (Hp) bacteria are the most prevalent cause of infection and inflammation in the foregut. Formerly, the presence of Hp infection in CD or T1DM subjects was found indifferent compared to controls [8][9][10][11][12][13][14][15]; however, contradictory data exist [16][17][18][19][20][21][22][23][24][25][26][27][28].…”

Section: Introductionmentioning

confidence: 99%

Helicobacter pylori Infection in Children with Concurrent Celiac Disease and Type 1 Diabetes Mellitus

Bayrak¹,

Volkan²

2021

Dig Dis

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Objectives: Data regarding Helicobacter pylori (Hp) infection frequency in concurrent celiac disease (CD) and type 1 diabetes mellitus (T1DM) (CD+T1DM) are anecdotal. This study aimed to evaluate the association between Hp and concomitant CD+T1DM in children. Methods: In this two-center, case-control study, children who underwent esophago-gastro-duodenoscopy were studied. CD diagnosis was established by favorable histology and serology. Hp infection was confirmed by both histology and the rapid urease test. Patients were divided into three groups as CD only (CDo), CD+T1DM, and non-CD children who underwent endoscopy as controls. Results: Among the 1431 esophago-gastro-duodenoscopies performed, 783 cases were eligible. Overall, 215 cases had CDo (mean age: 9.12±4.18 years, 58.1% girls), 63 cases had CD+T1DM (mean age: 9.29±4.46 years, 50.8% girls) and 505 cases were controls (mean age: 9.69±4.52 years, 56.6% girls). Hp infection rate was significantly lower in CD+T1DM group (controls: 49.7% vs CDo: 32.1% vs CD+T1DM: 20.6%, p<0.01). After adjustment for age, gender, and socioeconomic status, the Hp infection rate was still significantly low (aOR: 1.57, 95% CI: 1.35 – 1.83, p<0.01). A difference in Hp infection rate between controls and CDo group (aOR: 1.43, 95% CI: 1.09 – 2.12, p<0.05), and between CDo and CD+T1DM (aOR: 0.89, 95% CI: 0.65 – 1.54, p<0.05) group was significant. The severity of duodenal lesions and the presence of Hp infection was not correlated in all celiac children (r: 0.113, p>0.05). Conclusion: The frequency of Hp infection was significantly lower in CD+T1DM children, compared to the CDo group and the controls.

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“…On a similar trend, another group showed that H. pylori infected patients had a significantly higher HOMA‐IR level (diagnostic standard of insulin resistance) when compared with uninfected ones [90]. In a Japanese case report, the authors reported the onset of type 1 diabetes mellitus after H. pylori eradication [91]. The link with an autoimmune mechanism remains unclear.…”

Section: Other Diseasesmentioning

confidence: 90%

Helicobacters and Extragastric Diseases

et al. 2009

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For two decades, Helicobacter pylori has been considered as the culprit in many extragastric manifestations. However, for several of these supposed associations the hypothesis of an etiological role has not yet been fully investigated. This may be due to a series of factors linked to the epidemiological features of the studies and to the diseases investigated. This review attempts to highlight the main reported associations of H. pylori with extragastric manifestations during the last year. The most convincing data arise in the field of idiopathic thrombocytopenic purpura (ITP) and sideropenic anemia. Long-term follow-up studies have shown that 50% of subjects with ITP maintain a hematological response after H. pylori eradication. There is also growing evidence of the role of H. pylori in other diseases, including ischemic heart disease even though results are not conclusive.

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Eradication of Helicobactor pylori May Trigger Onset of Type 1 Diabetes

Cited by 3 publications

References 4 publications

The Eradication of Helicobacter pylori does not Affect Glycemic Control in Japanese Subjects with Type 2 Diabetes

The Eradication of Helicobacter pylori does not Affect Glycemic Control in Japanese Subjects with Type 2 Diabetes

<b><i>Helicobacter pylori</i></b> Infection in Children with Concurrent Celiac Disease and Type 1 Diabetes Mellitus

Helicobacters and Extragastric Diseases

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