Erbium(III) coordination compounds with substituted salicylaldehydes: Characterization and biological profile

Coordination Compounds of Nickel(II) with 3,5–Dibromo–Salicylaldehyde: Structure and Interaction with Biomolecules

“…The calculated K b values indicate a strong binding affinity of the complexes to DNA and are higher than that of the known intercalator EB (K b = 1.23 × 10 5 M −1 ) [73], showing that complexes 1-3 may be tighter DNA-binders than EB. The DNA-binding constants of complexes 1-3 are in the range 2.83(±0.70) × 10 5 -4.22(±0.86) × 10 5 M −1 and are of the same magnitude with those calculated for a series of coordination compounds bearing substituted salicylaldehydes as ligands [24][25][26][27][28]57,[61][62][63][64]74].…”

Cu(ii) complexes with a salicylaldehyde derivative and α-diimines as co-ligands: synthesis, characterization, biological activity. Experimental and theoretical approach

“…The binding constants of the compounds indicate that they can bind tightly to both albumins so that they can be transferred to possible biological target(s) and are of the same order as those reported for Cu( ii ), Cd( ii ), Mn( ii ), Zn( ii ), Ni( ii ), Pd( ii ) and Er( iii ) complexes with diverse substituted salicylaldehydes. 92–106 However, the binding is reversable, considering that the experimental binding constants are way smaller than the K values reported in literature for tightest known noncovalent binding of various ligands to avidin. 116 The reversable binding is essential for the release of complexes at their biotargets.…”

“…91 In total, the DNA-binding strength of the complexes is in the same range with a series of reported metal complexes having substituted salicylaldehydes as ligands. 92–106…”

“…91 In total, the DNA-binding strength of the complexes is in the same range with a series of reported metal complexes having substituted salicylaldehydes as ligands. [92][93][94][95][96][97][98][99][100][101][102][103][104][105][106] The interaction of complexes 1 and 2 with CT DNA was monitored by cyclic voltammetry based on the changes occurring to the Cu(II)/Cu(I) redox couple (the cathodic (E pc ) and anodic (E pa ) potentials of the couple as well as their shifts are given in Table 6) in the absence and presence of CT DNA. The addition of CT DNA in a solution of complex 1 resulted in a positive shift of both potentials, revealing the existence of an intercalative interaction mode (due to π-π stacking interactions via their aromatic ligands).…”

“…112 The Stern-Volmer constants (K SV ) (Table 7) are in the range reported for similar metal complexes with diverse substituted salicylaldehydes. [92][93][94][95][96][97][98][99][100][101][102][103][104][105][106] Given the fluorescence lifetime of the EB-DNA system as τ o = 23 ns, 112 the calculated (with eqn (S4), in the ESI †) quenching constants (k q ) are significantly higher than the value of 10 10 M −1 s −1 , 112 which is evidence of a static quenching mechanism. 111…”