Erdosteine ameliorates the harmful effects of ischemia-reperfusion injury on the liver of rats

Abstract

1 AbstractPurpose: To investigate the potential protective effects of erdosteine against the harmful effects of ischemia-reperfusion injury on the liver in an experimental rat model. Methods: Forty rats were divided into 4 groups. In the sham group, only the hepatic pedicle was mobilized. No other manipulation or treatment was performed. In the other groups, ischemia was achieved by clamping the hepatic pedicle for 60 min. After that, 90 min reperfusion was provided. In the control group, no treatment was given. In the perioperative treatment group, 100 mg/kg erdosteine was administered 2 hours before ischemia induction. In the preoperative treatment group, 100 mg/kg/day erdosteine was administered daily for ten days before the operation. At the end of the procedures, blood and liver samples were obtained for biochemical and histopathological assessment. Results: Treatment with erdosteine ameliorated the histopathological abnormalities when compared with the control group. Furthermore, this treatment significantly decreased the serum liver function test values. It was also found that erdosteine ameliorated the oxidative stress parameters in both the perioperative and preoperative treatment groups. Conclusion: The current study is the first to have shown the favorable effects of erdosteine on the harmful effects of experimental hepatic ischemia-reperfusion injury.

Assessment of effect of calcium dobesilate in experimental liver ischemia-reperfusion injury

“…Numerous experimental studies have been carried out in order to decrease the harmful effects of hepatic IRI. [6][7][8]25] However, there is still no pharmacological agent routinely used in clinical practice.…”

“…Barlas et al [25] investigated the effect of erdosteine on experimental liver IRI and found that erdosteine treatment relieved histopathological findings compared to the control group. Moreover, it was determined that this treatment improved liver function values and oxidative stress parameters.…”

Effects of artichoke leaf extract on hepatic ischemia-reperfusion injury

“…Many factors such as anaerobic metabolism, oxidative stress and ROS secretion, mitochondrial damage, and cytokines play a role in regulating hepatic I/R processes 16 . Although many studies have been conducted on the application of agents with protective effects to prevent hepatic I/R injury in experimental studies, there are no studies evaluating the efficacy of ALE [17][18][19] .…”

Protective effect of Coriandrum sativum extract against inflammation and apoptosis in liver ischaemia/reperfusion injury

“…After detaching of liver from the ligaments and hepatic pedicule (ductus hepaticus, hepatic portal vein and proper hepatic artery) was clamped with an atraumatic microvascular clamp and hepatic ischemia in the lobus hepatis mediana and lobus hepatis sinister. After 60 minutes of ischemia, the clamp was removed and 1 ml NaCl 0.9% was administered intraperitoneally, then the abdomen was closed and we waited 1 hour for reperfusion [15]. The other hepatic lobs had taken whole portal and arterial blood supply.…”