Erectile Dysfunction: An Underestimated Presentation in Patients with Diabetes Mellitus

Anwar, Zeeshan; Sinha, Vishal; Mitra, Sayantanava; Mishra, Ashwani Kumar; Ansari, Mahboobul Hasan; Bharti, Abhishek; Kumar, Vipin; Nigam, A. N.

doi:10.4103/0253-7176.217015

Cited by 23 publications

(22 citation statements)

References 37 publications

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“…The current study showed that prevalence of ED increased with increasing age that was agreed by many previous studies [19][20][21] . There was a significant association between severity of ED and age of the participant; 9.5% of patients below age of 60 had severe ED while 34% of patients over 60 had sever ED, this was agreed by Chaudhary et al, and Anwar et al, that reported, diabetes mellites patients with advanced age have a higher propensity of developing severe ED, which further deteriorates the already compromised health & quality of life [21,22] .…”

Section: Discussionsupporting

confidence: 92%

Pharmacodynamic Changes in Penile Color-Doppler Ultrasound of Diabetic Patients

Amin¹,

Hefeda

2019

The Medical Journal of Cairo University

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Background: Erectile dysfunction in diabetic patients leads to changes of intima, media, and Lumina of arteries resulting in atherosclerosis. Aims of Study:To determine the association between diabetes mellitus and penile Doppler ultrasonography changes in patients with erectile dysfunction. Also, the influence of duration, control of diabetes and diabetes complications on Doppler parameters. Settings and Design: Prospective cohort study, AndrologyMaterial and Methods: Thirty diabetic patients with ED and 10 age matched healthy controls were enrolled. Patients underwent assessment with international index of erectile function score, cavernosal artery ultrasonography during flaccid state for measurement of internal diameter, intima media thickness and arterial wall mass index. Followed by ICI to measure peak systolic velocity, end diastolic velocity and resistive index.Statistical Analysis Used: Mean, standard deviation and Chi-square test by SPSS V.16.Results: Diabetic patients with ED showed statistically significant decrease in IIEF score and PSV, increase in IMT and AWMI compared to controls. Positive correlation between duration of diabetes, blood glucose level and IMT and AWMI, Negative correlation between duration of diabetes and IIEF, PSV and erectile response. Negative correlation between blood glucose level and IIEF, PSV. Negative correlation between IMT, AWMI with IIEF.Conclusions: Diabetic patients with ED have a higher prevalence of atherosclerosis represented as increased IMT and AWMI compared with controls. Diabetes was an independent risk factor associated with atherosclerosis. Cavernosal artery IMT and AWMI interpreted clinically as negative correlation with erectile function domain of IIEF. These new parameters give good prediction for atherosclerosis and could replace more invasive ICI. Key Words: Erectile dysfunction -Intima media thickness -Arterial wall mass index. Key Messages:Ultrasound changes of diabetic patients include; increased IMT, AWMI, decreased PSV. IMT, AWMI are new parameters could be done in flaccid state and give the same level of accuracy considering predicting data for cavernosal arteries pathological changes which affect erectile function and could replace ICI and avoid its side effect.

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Section: Discussionsupporting

confidence: 92%

Pharmacodynamic Changes in Penile Color-Doppler Ultrasound of Diabetic Patients

Amin¹,

Hefeda

2019

The Medical Journal of Cairo University

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“…ED is a neurovascular phenomenon modulated by hormonal, local biochemical, and biomechanical factors [4-7]. Erectile dysfunction may signal serious underlying diseases, such as hypertension [2], diabetes mellitus [8,9], cardiovascular disease [10,11], peripheral vascular disease [12], and other endocrine [13] and neurological disorders [14,15].…”

Section: Introductionmentioning

confidence: 99%

Penile Doppler ultrasonography and elastography evaluation in patients with erectile dysfunction

Altınbaş

Hamidi²

2018

Pol J Radiol

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PurposeTo evaluate the relationship between erection grade, erectile function score, Doppler ultrasonography (US) indexes, and elasticity score (ES) according to Doppler US diagnosis in patients with erectile dysfunction (ED).Material and methodsReal-time strain type penile elastography was performed during penile Doppler US examination for 88 patients with ED. The diagnosis according to Doppler US was determined. Erection score according to the Erection Hardness Grading Scale was evaluated. A scoring for erectile function was performed with the International Index of Erectile Function (IIEF-5), and the Sexual Health Inventory for Men (SHIM) was defined. The relationships, according to Doppler diagnosis, of ES, IIEF-5 score, SHIM scale, and erection score were evaluated.ResultsAmong the patients, 50 (57%) had abnormal penile Doppler US findings. According to Doppler US findings, patients were classified as normal (n = 38), borderline for arterial insufficiency (n = 4), arterial insufficiency (n = 5), and venous insufficiency (n = 41). The lowest erection hardness grades and IIEF-5 scores were detected in patients with arterial failure. When compared to the normal group, in terms of ES, the arterial failure borderline group and venous failure group had lower scores, and the arterial failure group had a higher score. However, the only significant difference was obtained in the left cavernous body of the venous failure group.ConclusionsSonoelastography seems to add additional value for determination of stiffness of the penile cavernous body in routine evaluation of ED.

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“…[ 680 ] Men with T2DM and severe ED were found to have poor glycemic control, longer duration of untreated diabetes, later age of onset and poor quality of life. [ 681 ] …”

Section: R Ationale and E Videncementioning

confidence: 99%