Erectile Dysfunction and Andropause Symptoms in Infertile Men

O’Brien, Jeanne; Lazarou, Steve; Deane, Leslie A.; Jarvi, Keith; Zini, Armand

doi:10.1097/01.ju.0000177453.14334.a2

Cited by 51 publications

(36 citation statements)

References 18 publications

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“…Erectile dysfunction (IIEF-15-EFD score <26) was present iñ 20% of the study cohort. This prevalence is essentially in agreement with previous reports in infertile men (Jain et al, 2000;O'Brien et al, 2005;Shindel et al, 2008;Lotti et al, 2012), but is at least double than that observed in the general Italian population, when subjects with a similar mean age are considered (Parazzini et al, 2000;Mirone et al, 2004). The prevalence of ED in our patient population was further increased by the MetS condition, with hypertension and visceral adiposity as the main determinants.…”

Section: Discussionsupporting

confidence: 81%

Seminal, ultrasound and psychobiological parameters correlate with metabolic syndrome in male members of infertile couples

et al. 2013

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SUMMARYMetabolic syndrome (MetS) is a diagnostic category which identifies subjects at high risk for diabetes and cardiovascular diseases, erectile dysfunction (ED) and male hypogonadism. However, MetS impact on male infertility has been poorly studied. We systematically evaluated possible associations between MetS and clinical characteristics in men with couple infertility. Out of 367 consecutive subjects, 351 men without genetic abnormalities were studied. MetS was defined according to the International Diabetes Federation&American Heart Association/National Heart,Lung, and Blood Institute classification. All men underwent physical, hormonal, seminal and scrotal ultrasound evaluation. Erectile and ejaculatory functions were assessed by International Index of Erectile Function-15 erectile function domain (IIEF-15-EFD) and Premature Ejaculation Diagnostic Tool (PEDT), respectively, while psychological symptoms by Middlesex Hospital Questionnaire. Out of 351 patients, 27 (7.7%) fulfilled MetS criteria. Among ultrasound features, in an age-adjusted logistic model, only testis inhomogeneity was significantly associated with increasing MetS factors (HR = 1.36 [1.09-1.70]; p < 0.01). In an age-adjusted model, MetS was associated with a stepwise decline in total testosterone (TT) (B = À1.25 ± 0.33; p < 0.0001), without a concomitant rise in gonadotropins. At univariate analysis, progressive motility and normal morphology were negatively related to the number of MetS components (both p < 0.0001), but when age and TT were introduced in a multivariate model, only sperm morphology retained a significant association (B = À1.418 ± 0.42; p = 0.001). The risk of ED (IIEF-15-EFD score <26) increased as a function of the number of MetS factors, even after adjusting for age and TT (HR = 1.45[1.08-1.95]; p < 0.02). No association between PEDT score and MetS was observed. Finally, after adjusting for age and TT, somatization and depressive symptoms were associated with increasing MetS components (B = 0.66 ± 0.03, p < 0.05; B = 0.69 ± 0.03, p < 0.02; respectively). In conclusion, in men with couple infertility, MetS is associated with hypogonadism, poor sperm morphology, testis ultrasound inhomogeneity, ED, somatization and depression. Recognizing MetS could help patients to improve not only fertility but also sexual and overall health.

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Section: Discussionsupporting

confidence: 81%

Seminal, ultrasound and psychobiological parameters correlate with metabolic syndrome in male members of infertile couples

et al. 2013

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“…Erectile dysfunction has been correlated with male infertility. In participants who answered the Sexual Health Inventory questionnaire, 27% of infertile men reported erectile dysfunction compared with 11% of the fertile control group (66).…”

Section: Obesity and Sexual Dysfunctionmentioning

confidence: 99%

Impact of male obesity on infertility: a critical review of the current literature

Hammoud

Gibson

Peterson

et al. 2008

Fertility and Sterility

310

247

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“…In the literature, several studies have reported a higher prevalence of ED in infertile male patients compared with the male general population (Jain et al, 2000;Monga et al, 2004;O'Brien et al, 2005;Shindel et al, 2008;Lotti et al, 2012;Gao et al, 2013), see Table 1 for details. Shindel et al (2008) indicated that the incidence of ED in the male infertile population (22%) was higher than that observed in a male population of the same age (7 to 9%).…”

Section: Erectile Dysfunctionmentioning

confidence: 99%

Male infertility: an obstacle to sexuality?

2016

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SUMMARYInteractions between infertility and sexuality are numerous and complex. Infertile men may suffer from sexual dysfunction (SD) when undergoing an assisted reproductive technology programme. We undertook a review both in French and English of the available data on male SD when being diagnosed with a fertility problem with a specific focus on azoospermic men. The review was performed over a 30-year time period using PubMed/Medline. The sexual concerns and needs of infertile/sterile men for whom potential parenting can be compromised were evaluated. When diagnosed with infertility, men usually go through a crisis that can have a deleterious effect on their sexuality with sometimes a feeling of sexual inadequacy. Infertile men will feel stigmatized because they are perceived as being deficient in a specific component of their masculinity. Hence, subsequent SD may occur that can impact the couple sexuality and the infertility management. However, little is known on how the announcement of azoospermia may affect male on a sexual and psychological point of view. The present review suggests that a global management through a healthcare network (biologist, andrologist, sexologist and psychologist) is required which will allow to consider infertility and its subsequent sexual disorders as a whole and not as dichotomized issues.

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Erectile Dysfunction and Andropause Symptoms in Infertile Men

Abstract: Andropause symptoms and erectile dysfunction are common among infertile men, affecting approximately 38% of this population. This finding suggests that the population of infertile men should be carefully screened to identify and treat those with erectile dysfunction.

Cited by 51 publications

References 18 publications

Seminal, ultrasound and psychobiological parameters correlate with metabolic syndrome in male members of infertile couples

Seminal, ultrasound and psychobiological parameters correlate with metabolic syndrome in male members of infertile couples

Impact of male obesity on infertility: a critical review of the current literature

Male infertility: an obstacle to sexuality?

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