Erectile Dysfunction and Risk of Cardiovascular Disease

Dong, Jia-Yi; Zhang, Yonghong; Li, Qin

doi:10.1016/j.jacc.2011.06.024

Cited by 415 publications

(263 citation statements)

References 42 publications

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“…6 • ED not only shares risk factors with CVD 7,8 but also is, in itself, an independent marker of increased risk for CVD (ACCF/AHA class Ia). [9][10][11][12][13][14][15] • ED is a marker of significantly increased risk of CVD, coronary artery disease (CAD), stroke, and all-cause mortality.…”

Section: Sexual Inquiry Of All Menmentioning

confidence: 99%

The Princeton III Consensus Recommendations for the Management of Erectile Dysfunction and Cardiovascular Disease

Nehra

Jackson

Miner

et al. 2012

Mayo Clinic Proceedings

420

341

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The Princeton Consensus (Expert Panel) Conference is a multispecialty collaborative tradition dedicated to optimizing sexual function and preserving cardiovascular health. The third Princeton Consensus met November 8 to 10, 2010, and had 2 primary objectives. The first objective focused on the evaluation and management of cardiovascular risk in men with erectile dysfunction (ED) and no known cardiovascular disease (CVD), with particular emphasis on identification of men with ED who may require additional cardiologic work-up. The second objective focused on reevaluation and modification of previous recommendations for evaluation of cardiac risk associated with sexual activity in men with known CVD. The Panel's recommendations build on those developed during the first and second Princeton Consensus Conferences, first emphasizing the use of exercise ability and stress testing to ensure that each man's cardiovascular health is consistent with the physical demands of sexual activity before prescribing treatment for ED, and second highlighting the link between ED and CVD, which may be asymptomatic and may benefit from cardiovascular risk reduction. T he Princeton Consensus Conference is a multispecialty collaborative tradition dedicated to optimizing sexual function and preserving cardiovascular health. The first conference convened in June 1999 to develop recommendations for clinical management of sexual dysfunction in men and women with known cardiovascular disease (CVD). This conference also provided a multidisciplinary forum for evaluation of the potential cardiovascular risk posed by sexual activity in atrisk patients. The first Princeton Consensus Conference recommendations 1 included stratification of patients by level of cardiac risk associated with sexual activity based on existing CVD. Those at low risk could initiate or resume sexual activity and be treated for sexual dysfunction. For those at high risk, sexual activity was deferred until the cardiac condition was stabilized. The second Princeton Consensus Conference convened in June 2004 and expanded the recommendations of the first conference to emphasize risk factor evaluation and lifestyle management for all men with erectile dysfunction (ED). 2 The second conference recommendations also incorporated new information on the appropriate use of phosphodiesterase type 5 (PDE5) inhibitors in men with ED and concomitant CVD.The third Princeton Consensus Conference took place November 8 to 10, 2010, in Miami Beach, Florida. The group revisited and updated their 2005 recommendations regarding the cardiovascular risk associated with sexual activity in men with known CVD. 2 In addition, the third conference focused on the predictive value of vasculogenic ED in assigning cardiovascular risk in men of all ages, with the primary objective being development of an approach to cardiovascular risk assessment in younger men with ED and no known CVD. The role of testosterone in erectile function and cardiovascular health and the utility of testosterone replacement...

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Section: Sexual Inquiry Of All Menmentioning

confidence: 99%

The Princeton III Consensus Recommendations for the Management of Erectile Dysfunction and Cardiovascular Disease

Nehra

Jackson

Miner

et al. 2012

Mayo Clinic Proceedings

420

341

View full text Add to dashboard Cite

show abstract

“…Since ED often precedes vascular disease diagnosis in patients, several authors consider ED as a surrogate symptom of occult vascular disease (Kirby et al 2001) and as a predictive marker for CVD (Billups et al 2008;Jackson et al 2006;Kirby et al 2001) and even acute cardiac events (Chew et al 2010;Jackson 2008;Kostis et al 2005). Recently, ED itself was also considered an independent risk factor of CVD (Dong et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Energy restriction ameliorates metabolic syndrome-induced cavernous tissue structural modifications in aged rats

Tomada

Fernandes

Guimarães

et al. 2012

AGE

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High-fat (HF) diet regular intake along life highly contributes to vascular dysfunction and to an increment in prevalence of metabolic syndrome (MetS) and erectile dysfunction (ED), a surrogate symptom of occult vascular disease, in the elderly. However, little is known about the effects of energy restriction (ER) alone/or after an HF-feeding period. We show here that in male Sprague-Dawley rats, 16 months of HF-diet consumption led to an increase in body adiposity, blood pressure, lipidemia, C-reactive protein, and insulin resistance and to hypoadiponectinemia, conditions that cluster in MetS. In addition, this treatment strongly favored collagen deposition in cavernous tissue and myocardium. Conversely, for the same time period, the ingestion of 75 % of ad libitum energy intake by controls (ER) extensively counteracted these outcomes. The impact of 6-month ER after 10-month HF period was also analyzed, and despite the decrease in body weight, adiposity, blood pressure, lipidemia, and Creactive protein and improvement of insulin sensitivity, no differences were observed either in adiponectin blood levels or in retroperitoneal fat pad mass. Moreover, this treatment led to a reduction in cavernous tissue collagen deposition, but not in the myocardium, and evidenced differential mobilization of adipose tissue accretions. The data show the ability of HF diet to cause MetS and produce unwanted effects on myocardium and corpora vascular structure. They also indicate that these consequences are preventable upon ER diet starting early, but not later, in life.

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“…Podsumowanie zaleceń dotyczących strategii leczenia u pacjentów z nadciśnieniem i miażdżycą, stwardnieniem naczyń lub chorobą tętnic obwodowych czynnik ryzyka sercowo-naczyniowego i wczesny wskaźnik diagnostyczny subklinicznych lub jawnych powikłań narzą-dowych [591]. Dlatego też pełny wywiad powinien obejmować również zagadnienia dotyczące funkcji seksualnych.…”

Section: Choroba Tętnic Obwodowychunclassified

Wytyczne ESH/ESC dotyczące postępowania w nadciśnieniu tętniczym w 2013 roku

Mancia

Fagard

Redón³

et al. 2013

Kardiol Pol

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Erectile Dysfunction and Risk of Cardiovascular Disease

Abstract: This meta-analysis of prospective cohort studies suggests that ED significantly increases the risk of CVD, coronary heart disease, stroke, and all-cause mortality, and the increase is probably independent of conventional cardiovascular risk factors.

Cited by 415 publications

References 42 publications

The Princeton III Consensus Recommendations for the Management of Erectile Dysfunction and Cardiovascular Disease

The Princeton III Consensus Recommendations for the Management of Erectile Dysfunction and Cardiovascular Disease

Energy restriction ameliorates metabolic syndrome-induced cavernous tissue structural modifications in aged rats

Wytyczne ESH/ESC dotyczące postępowania w nadciśnieniu tętniczym w 2013 roku

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