Erectile Dysfunction Is Associated with Left Ventricular Diastolic Dysfunction: A Systematic Review and Meta-analysis

Durukan, Emil; Jensen, Christian; Skaarup, Kristoffer Grundtvig; Østergren, Peter Busch; Sønksen, Jens; Fode, Mikkel

doi:10.1016/j.euf.2023.06.001

Cited by 5 publications

(4 citation statements)

References 41 publications

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“…Our study findings align with prior research that has demonstrated a correlation between ED and LVDD [ 17 21 ], and this correlation has also been recently affirmed through a systematic review [ 22 ]. However, previous studies predominantly relied on the assessment of ED through only the IIEF scores, which could be a subjective patient assessment.…”

Section: Discussionsupporting

confidence: 92%

The association between the severity of erectile dysfunction and left ventricular diastolic dysfunction in patients with and without cardiovascular disease

Hyun,

Hwang,

Yun

et al. 2024

Investig Clin Urol

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Purpose Erectile dysfunction (ED) is considered a microvascular disorder and serves as an indicator for the potential development of cardiovascular disease (CVD). Although left ventricular diastolic dysfunction (LVDD) reflects early myocardial damage caused by microvascular disorders, the association between ED and LVDD remains poorly elucidated. Materials and Methods A cross-sectional study was conducted on 123 patients with ED. They underwent RigiScan, and conventional echocardiography, and attempted International Index of Erectile Function (IIEF) questionnaire. ED severity was evaluated by measuring changes in the penile base circumference and duration of penile rigidity (≥70%) during erection. The early diastolic velocity of mitral inflow (E) and early diastolic velocity of the mitral annulus (e′) were measured using echocardiography. The patients were grouped based on the presence of CVD. Results Among 123 patients, 29 had CVD and 94 did not. Patients with CVD exhibited more pronounced ED and more severe LVDD. Associations between increased penile circumference with echocardiographic parameters were more prominent in patients with CVD than in those without CVD (ΔTtop and e′ wave, r=0.508 and r=0.282, respectively, p for interaction=0.033; ΔTbase and E/e′ ratio, r=-0.338 and r=-0.293, respectively, p for interaction <0.001). In the multivariate linear regression, the increase of penile base circumference was an independent risk factor for LVDD (e′, B=0.503; E/e′ ratio, B=-1.416, respectively, p<0.001). Conclusions ED severity correlated well with LV diastolic dysfunction, particularly in the presence of CVD. This study highlighted the potential role of ED assessment as early indicator of CVD development.

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Section: Discussionsupporting

confidence: 92%

The association between the severity of erectile dysfunction and left ventricular diastolic dysfunction in patients with and without cardiovascular disease

Hyun,

Hwang,

Yun

et al. 2024

Investig Clin Urol

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“…In conclusion, this study highlights the potential of ED assessment as an early indicator of CVD development. This aligns with current research trends that emphasize the importance of early detection and multidisciplinary approaches in managing conditions like ED and CVD [ 3 4 ]. The study’s findings are significant in the context of preventive healthcare, suggesting that monitoring and treating ED could also have implications for cardiovascular health.…”

Section: To the Editorsupporting

confidence: 78%

Letter to the editor: The association between the severity of erectile dysfunction and left ventricular diastolic dysfunction in patients with and without cardiovascular disease

Park

2024

Investig Clin Urol

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“…показано, что при впервые диагностированной Аг наличие и тяжесть эд связаны с толщиной эпикардиальной жировой ткани и толщины интима-медиа сонных артерий, а диастолическая функция левого желудочка больше нарушается у пациентов с эд [76]. эд чаще встречается у пациентов с Аг и установленной ишемической болезнью сердца, перенесёнными инфарктом миокарда и/или инсультом, чем при отсутствии этих осложнений в анамнезе [77,78].…”

Section: результатыunclassified

Sexual dysfunction in men and women with arterial hypertension

Kanorskii

2024

jour

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Sexual dysfunction is often associated with hypertension but is not recognized, reported, or adequately treated. Research on sexual dysfunction is sparse, which may be due to the taboo nature of the topic. A literature search was conducted in five databases (PubMed, Web of Science, Scopus, Cochrane Library and PsycINFO) to identify articles published over the past ten years (from 2014 to 2024), using the keywords “sexual dysfunction”, “arterial” hypertension", "antihypertensive drugs", "erectile dysfunction". The review examines the prevalence, pathophysiology, clinical manifestations of sexual dysfunction in men and women, its relationship with arterial hypertension, antihypertensive therapy, concomitant pathology, and possible methods of correction.

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Erectile Dysfunction Is Associated with Left Ventricular Diastolic Dysfunction: A Systematic Review and Meta-analysis

Cited by 5 publications

References 41 publications

The association between the severity of erectile dysfunction and left ventricular diastolic dysfunction in patients with and without cardiovascular disease

The association between the severity of erectile dysfunction and left ventricular diastolic dysfunction in patients with and without cardiovascular disease

Letter to the editor: The association between the severity of erectile dysfunction and left ventricular diastolic dysfunction in patients with and without cardiovascular disease

Sexual dysfunction in men and women with arterial hypertension

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