Eremophilane Sesquiterpenes and Benzene Derivatives from the Endophyte Microdiplodia sp. WGHS5

Abstract

Three new eremophilane sesquiterpenes phomadecalins G−I (1–3) and two new benzene derivatives microdiplzenes A and B (12 and 13), together with nine known eremophilane sesquiterpenes (4–11 and 14) were isolated from an endophytic fungus, Microdiplodia sp. WGHS5. Their structures were elucidated by the interpretation of HR‐ESI‐MS and NMR data; meanwhile, the absolute configurations of new compounds were determined on the base of ECD calculations. All compounds were evaluated for the antimicrobial activities and antiproliferative effect on human gastric cancer cell lines (BGC‐823).

Cumulative Data of 1H and 13C NMR Signals and Specific Rotations of Eremophilane Sesquiterpenoids. 1. Bicyclic Eremophilanes (1)

“…The configurations at C-11 of compounds 319 , and 321 – 323 are not determined. The CD spectra of acemeremophilane A ( 317 ), 58 phomadecalin H ( 318 ), 135 and phomadecalin G ( 320 ) 135 were measured. The numbering system used in acemeremophilane A ( 317 ) was changed to the present system.…”

Chemical Investigation of Endophytic Diaporthe unshiuensis YSP3 Reveals New Antibacterial and Cytotoxic Agents

“…The inhibitory effects of isolated compounds on the HeLa and MCF-7 cells were assessed in vitro by using the MTT assay on a 96-well plate. Experimental details of test used in this study are summarized in previous reports [ 21 , 22 ]. The toxicities against normal LO2 and HaCaT cells were tested via the cell counting kit-8 (CCK-8) method, similar to the reported reference [ 23 ].…”

Antibacterial and Antifungal Sesquiterpenoids: Chemistry, Resource, and Activity

“…The results revealed that 87 had equivalently effective antifungal activity against B. cinerea and F. graminearum at 100 μg/mL. [ 47 ].…”