Neom city is a unique cross-border city connecting Saudi Arabia, Jordan, and Egypt. Although Neom city is of great and critical importance for Saudi Arabia, few hydrological, natural hazard, and geomorphological studies have been undertaken on this region. This work aims to investigate the hydro-geomorphological characteristics and assess the flash flood hazards in Neom city by investigating several valuable morphometric parameters. The Shutter Radar Topography Mission (SRTM) digital elevation model and hydrological and geological data were analyzed in this study using ArcGIS software. Based on the morphometric parameter results, total stream lengths and stream orders were relatively high (17,956.03 km and 5, respectively), whereas the average bifurcation ratio was recorded to be low at 3.54. Basins 10, 12, 17, 30, 31, 32, and 34 were described as large basins, coarse-textured, elongated, with a medium drainage density, low infiltration values, long overland flows, and high values of constant maintenance. Additionally, the El-Shamy approach for flood hazard assessment was applied side by side with the morphometric analysis, which indicated that the possibility of an intense flood hazard is very low. In general, this study suggests that most of the studied basins cover similar and resistant rocks and soils. They have minimal conditions for flooding events and suitable conditions for underground and surface water resources. Therefore, they display high signals of susceptibility to erosion. The morphometric analysis and flash flood assessment techniques applied in this study were time- and cost-effective for the morphometric characterization of landforms. This text deals with the analysis of several environmental characteristics including hydro-morphological characteristics, drainage topography and lithology, soil erosion, groundwater recharge impact, and flash flood signals. Excellent sustainability plans should be reliant on extensive and varied information about the environment. Thus, integrated analyses incorporating environmental characteristics and flood hazard assessment play an important role in adjusting and adapting the suitable socioeconomic and scientific sustainability of the development of the study city. They build up the basic and essential information required to help decision-makers and sustainability managers design and adjust the most suitable sustainability plans for the study city over the long term.