Erratum: A Novel, Stable, Estradiol-Stimulating, Osteogenic Yam Protein with Potential for the Treatment of Menopausal Syndrome

Wong, Ka-Lok; Lai, Yau Ming; Li, Ka Wan; Lee, Ckf; Ng, Tzi Bun; Cheung, Ho Pan; Zhang, Yan Bo; Lao, Lixing; Wong, Ricky N S; Shaw, Pang‐Chui; Wong, Jack Ho; Zhang, Zhang-Jin; Lam, Jenny K.W.; Ye, Wen‐Cai; Sze, Stephen Cho Wing

doi:10.1038/srep17129

Cited by 14 publications

(14 citation statements)

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“…The batatasin family of phytohormones are classed as phenantrenes, and their ability to inhibit α-glucosidase may in part explain the anti-diabetic effects described above (Hu et al 2015 ). Another potentially valuable ingredient is the DOI protein, which belongs to the chitinase-like superfamily but shows negligible chitinase enzyme activity (Wong et al 2015 ). This protein can stimulate estradiol biosynthesis in rat cells, and is currently being investigated as a protein-based drug for the treatment of menopausal syndrome (Sze et al 2013 ; Wong et al 2015 ).…”

Section: Chinese Yam Ingredients With Health Benefits and Other Usefumentioning

confidence: 99%

“…Another potentially valuable ingredient is the DOI protein, which belongs to the chitinase-like superfamily but shows negligible chitinase enzyme activity (Wong et al 2015 ). This protein can stimulate estradiol biosynthesis in rat cells, and is currently being investigated as a protein-based drug for the treatment of menopausal syndrome (Sze et al 2013 ; Wong et al 2015 ).…”

Section: Chinese Yam Ingredients With Health Benefits and Other Usefumentioning

confidence: 99%

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An underutilized orphan tuber crop—Chinese yam : a review

Epping¹,

Laibach

2020

Planta

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Main conclusion The diversification of food crops can improve our diets and address the effects of climate change, and in this context the orphan crop Chinese yam shows significant potential as a functional food. Abstract As the effects of climate change become increasingly visible even in temperate regions, there is an urgent need to diversify our crops in order to address hunger and malnutrition. This has led to the re-evaluation of neglected species such as Chinese yam (Dioscorea polystachya Turcz.), which has been cultivated for centuries in East Asia as a food crop and as a widely-used ingredient in traditional Chinese medicine. The tubers are rich in nutrients, but also contain bioactive metabolites such as resistant starches, steroidal sapogenins (like diosgenin), the storage protein dioscorin, and mucilage polysaccharides. These health-promoting products can help to prevent cardiovascular disease, diabetes, and disorders of the gut microbiome. Whereas most edible yams are tropical species, Chinese yam could be cultivated widely in Europe and other temperate regions to take advantage of its nutritional and bioactive properties. However, this is a laborious process and agronomic knowledge is fragmented. The underground tubers contain most of the starch, but are vulnerable to breaking and thus difficult to harvest. Breeding to improve tuber shape is complex given the dioecious nature of the species, the mostly vegetative reproduction via bulbils, and the presence of more than 100 chromosomes. Protocols have yet to be established for in vitro cultivation and genetic transformation, which limits the scope of research. This article summarizes the sparse research landscape and evaluates the nutritional and medical applications of Chinese yam. By highlighting the potential of Chinese yam tubers, we aim to encourage the adoption of this orphan crop as a novel functional food.

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Section: Chinese Yam Ingredients With Health Benefits and Other Usefumentioning

confidence: 99%

Section: Chinese Yam Ingredients With Health Benefits and Other Usefumentioning

confidence: 99%

An underutilized orphan tuber crop—Chinese yam : a review

Epping¹,

Laibach

2020

Planta

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“…The population of postmenopausal women is increasing in an aging society. The total worldwide population of postmenopausal women was 477 million in 1998, and it is predicted that this population will reach 1200 million by 2030 1 . Osteoporosis is most common in postmenopausal women.…”

Section: Introductionmentioning

confidence: 99%

Isoflavone‐enriched soybean leaves attenuate ovariectomy‐induced osteoporosis in rats by anti‐inflammatory activity

et al. 2020

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BACKGROUND With an increasing aging population, postmenopausal osteoporosis has become a global public health problem. Previous evidence has shown that postmenopausal osteoporosis is a skeletal disease mainly caused by estrogen deficiency, generally accompanied by inflammation, and dietary isoflavones may ameliorate postmenopausal osteoporosis by anti‐inflammatory activity. We have generated isoflavone‐enriched soybean leaves (IESLs), but their anti‐inflammatory activity and effect on attenuating osteoporosis are still obscure. Here, we determined the isoflavone profiles of IESLs and evaluated their anti‐inflammatory activity in lipopolysaccharide‐stimulated RAW 264.7 cells and anti‐osteoporotic effects on ovariectomy‐induced osteoporosis in rats. RESULTS IESLs had a high content of total isoflavone. Hydrolysate of IESLs (HIESLs) was rich with the aglycones daidzein and genistein, and HIESLs can significantly inhibit lipopolysaccharide‐induced inflammation by reducing messenger RNA expression of iNOS, COX‐2, IL6, and IL1β. Moreover, ovariectomized rats receiving aqueous extracts of IESLs (HIESLs) orally maintained more bone mass than control rats did, which was attributed to inhibition of osteoclastogenesis by downregulating the messenger RNA expression of the bone‐specific genes RANKL/OPG, OC, and cathepsin K, and the inflammation‐related genes IL6, NFκB, and COX‐2. CONCLUSION IESLs may attenuate postmenopausal osteoporosis by suppressing osteoclastogenesis with anti‐inflammatory activity and be a potential source of functional food ingredients for the prevention of osteoporosis. © 2020 Society of Chemical Industry

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“…In traditional medicine, wild yam is widely used to treat menopausal symptoms, most likely due to its phytoestrogen content and corresponding ability to stimulate ovarian estradiol synthesis [109][110][111]. In one study [112], twenty-four healthy postmenopausal women replaced their staple food of rice with 390 grams of yam or sweet potato (control) in two of the three meals per day for thirty days.…”

Section: Wild Yam (Dioscorea)mentioning

confidence: 99%

A Review of the Science of Colorful, Plant-Based Food and Practical Strategies for “Eating the Rainbow”

Minich

2019

Journal of Nutrition and Metabolism

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Over the past decades, thousands of published studies have amassed supporting recommendations to consume fruits and vegetables for physiological and psychological health. Newer research has emerged to suggest that these plant-based foods contain a plethora of not only vitamins and minerals, but perhaps, most importantly, phytonutrients. These phytonutrients have known pleiotropic effects on cellular structure and function, ultimately resulting in the modulation of protein kinases and subsequent epigenetic modification in a manner that leads to improved outcomes. Even though eating fruits and vegetables is a well-known feature of a healthy dietary pattern, population intakes continue to be below federal recommendations. To encourage consumers to include fruits and vegetables into their diet, an “eat by color” approach is proposed in this review. Although each individual food may have numerous effects based on its constituents, the goal of this simplified approach was to identify general patterns of benefits based on the preponderance of scientific data and known mechanisms of food-based constituents. It is suggested that such a consumer-oriented categorization of these plant-based foods may lead to greater recognition of their importance in the daily diet throughout the lifespan. Other adjunctive strategies to heighten awareness of fruits and vegetables are discussed.

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Erratum: A Novel, Stable, Estradiol-Stimulating, Osteogenic Yam Protein with Potential for the Treatment of Menopausal Syndrome

Abstract: The original version of this Article contained an error in the spelling of the author Wen-cai Ye, which was incorrectly given as Ye Wencai.

Cited by 14 publications

References 0 publications

An underutilized orphan tuber crop—Chinese yam : a review

An underutilized orphan tuber crop—Chinese yam : a review

Isoflavone‐enriched soybean leaves attenuate ovariectomy‐induced osteoporosis in rats by anti‐inflammatory activity

A Review of the Science of Colorful, Plant-Based Food and Practical Strategies for “Eating the Rainbow”

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