Erratum: A positive role for polycomb in transcriptional regulation via H4K20me1

Lv, Xiangdong; Han, Zhijun; Chen, Hao; Yang, Bo; Yang, Xiaofeng; Xia, Yuanxin; Pan, Chenyu; Fu, Lin; Zhang, Shuo; Han, Hui; Wu, Min; Zhou, Zhaocai; Zhang, Lei; Lin, Li; Wei, Gang; Zhao, Yun

doi:10.1038/cr.2017.50

Cited by 4 publications

(4 citation statements)

References 32 publications

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“…At ZT12, most of the mRNA levels of the clock genes are at their extremes, either at the peak or the trough ( Patke et al, 2020 ). Pc function can be either activation or inhibition ( Morey & Helin, 2010 ; Lv et al, 2017 ). To the best of our understanding, PcG complex can stabilize gene expression during the stress context ( Zhao et al, 2021a , 2021b ).…”

Section: Discussionmentioning

confidence: 99%

“…As shown in Fig 6L–U , we checked the expression level of clock genes. Pc can function as both repressor or activator ( Morey & Helin, 2010 ; Lv et al, 2017 ). Moreover, as discussed above, in some cases, non-clock neurons were targeted in this study.…”

Section: Discussionmentioning

confidence: 99%

“…Pc has direct downstream targets (bound by Pc) and indirect downstream targets (not bound by Pc). As shown in Fig 6L-U, we checked the expression level (A, B, C, D, E, F, G, H, I, J, K (Morey & Helin, 2010;Lv et al, 2017). Moreover, as discussed above, in some cases, non-clock neurons were targeted in this study.…”

Section: Discussionmentioning

confidence: 99%

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Polycombregulates circadian rhythms inDrosophilain clock neurons

Zhao,

Yang,

et al. 2023

Life Sci. Alliance

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Circadian rhythms are essential physiological feature for most living organisms. Previous studies have shown that epigenetic regulation plays a crucial role. There is a knowledge gap in the chromatin state of some key clock neuron clusters. In this study, we show that circadian rhythm is affected by the epigenetic regulatorPolycomb(Pc) within theDrosophilaclock neurons. To investigate the molecular mechanisms underlying the roles ofPcin these clock neuron clusters, we use targeted DamID (TaDa) to identify genes significantly bound by Pc in the neurons marked byC929-Gal4(including l-LNvs cluster),R6-Gal4(including s-LNvs cluster),R18H11-Gal4(including DN1 cluster), andDVpdf-Gal4,pdf-Gal80(including LNds cluster). It shows that Pc binds to the genes involved in the circadian rhythm pathways, arguing a direct role forPcin regulating circadian rhythms through specific clock genes. This study shows the identification of Pc targets in the clock neuron clusters, providing potential resource for understanding the regulatory mechanisms of circadian rhythms by the PcG complex. Thus, this study provided an example for epigenetic regulation of adult behavior.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Polycombregulates circadian rhythms inDrosophilain clock neurons

Zhao,

Yang,

et al. 2023

Life Sci. Alliance

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“…Interestingly, data obtained from the ReSE screen also showed a positive association of silencers with methylation of histone H4 Lys20 (H4K20), a histone modification often associated with cell cycle dynamics and thought to regulate various processes related to DNA damage and chromosome condensation 62,[91][92][93] . Although previous studies showed an association of H4K20me1 with both transcription activation and repression, the precise role of H4K20me1 in regulating gene expression and, more specifically, a possible role in silencer activity is largely unclear 91 .…”

Section: Epigenomic and Other Characteristicsmentioning

confidence: 99%