Erratum and further analysis: ‘'Perinatal conditions and infant development in children with schizophrenic parents”

Mednick, Sarnoff A.; Mura, Elaine L.; Schulsinger, Fini; Mednick, Birgitte R.

doi:10.1080/19485565.1973.9988028

Cited by 24 publications

(3 citation statements)

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“…found that children of schizophrenic mothers appeared to be especially vulnerable to attentional deficit compared to children born to healthy mothers. Developmental delay was also found in 1‐year‐old children born with low birthweight to mothers with schizophrenia …”

Section: Results (Table )mentioning

confidence: 94%

Schizophrenia and motherhood

Gentile¹,

Fusco²

2019

Psychiatry Clin Neurosci

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The primary aim of this study was to analyze the impact of schizophrenic disorders on pregnancy outcomes. The secondary aim was to briefly analyze the potential role of antipsychotic treatment on influencing pregnancy outcomes in expectant mothers with schizophrenia. We searched the MEDLINE, PsycINFO, and http://Science.gov databases for articles published in English from January 1980 to January 2019. We used the following search terms: ‘schizophrenia’, ‘motherhood’, ‘pregnancy/foetal/neonatal outcomes’, and ‘birth defects’. The reference lists of retrieved articles were also consulted to find additional pertinent studies missed in the electronic search and/or those published before 1980. Data were extracted from articles that provided primary data on the impact of maternal schizophrenia spectrum disorders on obstetrical and perinatal outcomes. After excluding duplicates, 35 articles were identified. Systematic reviews were searched on the same databases to briefly assess the effects of antipsychotics on pregnancy outcomes. The reviewed studies showed several limitations. They were published during a time range from the early 1970s to 2019. During this period, there were significant changes in the diagnostic criteria for schizophrenia. Moreover, such studies showed no homogeneity in the investigation of potential confounders. Most importantly, no research has differentiated the effects of maternal illness on pregnancy, fetal, and neonatal outcomes from those associated with antipsychotic treatments. Thus, it is not surprising that such studies show conflicting results. Despite such limitations, in managing pregnant women with schizophrenia clinicians should consider an integrated approach that includes: antipsychotic treatment, psychological treatment, optimal dietary approaches for prevention of excessive weight gain and gestational diabetes, meticulous gynecologic and obstetric surveillance, and social and occupational support.

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Section: Results (Table )mentioning

confidence: 94%

Schizophrenia and motherhood

Gentile¹,

Fusco²

2019

Psychiatry Clin Neurosci

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“…In some studies (Marcus et al 1981;Goodman & Emory, 1992) recognized operational criteria, such as DSM-III or the Research Diagnostic Criteria, were used. In other studies (e.g Mednick et al 1971Mednick et al , 1973Mirdal et al 1974;Cohler et al 1975;Rieder et al 1975Rieder et al , 1977 the criteria for diagnosis are stated to be, or to be based on, those of Kety et al (1968). In other studies, the diagnostic guidelines adopted are described.…”

Section: Methods Criteria For Inclusion Of Individual Studiesmentioning

confidence: 99%

Obstetric complications in children born to parents with schizophrenia: a meta-analysis of case–control studies

1996

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SynopsisOn the basis of previous findings, we used meta-analyses to consider whether births to parents with schizophrenia have an increased risk of obstetric complications. Meta-analyses were based on published studies satisfying the following selection criteria. The schizophrenic diagnosis could apply to either parent: parents with non-schizophrenic psychoses were not included: only normal controls were accepted. In all, 14 studies provided effect sizes or data from which these could be derived. Studies were identified by data searches through MEDLINE, PSYCLIT and through references of papers relating to the subject. Births to individuals with schizophrenia incur an increased risk of pregnancy and birth complications, low birthweight and poor neonatal condition. However, in each case the effect size is small (mean r = 0·155; 95% CI = 0·057). The risk is greater for mothers with schizophrenia and is not confined to mothers with onset pre-delivery or to the births of the children who become schizophrenic themselves.

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“…O n the other hand, the results of Gottesman & Shields (1972) did not confirm this trend, and their analysis of the data from published twin studies with representative sampling did not support any relationship between low birthweight and future schizophrenia. More recently Mednick et al (1971Mednick et al ( , 1973 found decreased birthweight among the offspring of schizophrenic women, and McNeil & Kaij (1973a) found a tendency for the offspring of schizophrenics to be small (light) for gestational age.…”

Section: Pbc's and Subsequent Psychiatric Breakdownmentioning

confidence: 99%

Perinatal Complications in Children of Schizophrenic Mothers

Mirdal

Mednick

Schulsinger

et al. 1974

Acta Psychiatr Scand

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Rates of pregnancy and birth complications (PBC's) were studied in 166 children born to 112 schizophrenic women (high risk) and 90 children born to 84 normal controls (low risk). No significant differences were found between the two groups taken as a whole, either in the number or in the severity of PBC's. However, significantly higher rates of PBC's were found to accompany the first pregnancies and deliveries of schizophrenic women as compared to the first reproductions of normal women. Furthermore, whereas normal women tended to have higher rates of PBC's with increasing age and parity, neither age nor delivery number seemed to affect the rate of PBC's among schizophrenic women.

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Erratum and further analysis: ‘'Perinatal conditions and infant development in children with schizophrenic parents”

Cited by 24 publications

References 0 publications

Schizophrenia and motherhood

Schizophrenia and motherhood

Obstetric complications in children born to parents with schizophrenia: a meta-analysis of case–control studies

Perinatal Complications in Children of Schizophrenic Mothers

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