Erratum: Cardiac RKIP induces a beneficial β-adrenoceptor–dependent positive inotropy

Schmid, Evelyn; Neef, Stefan; Berlin, Christopher; Tomasovic, Angela; Kahlert, Katrin; Nordbeck, Peter; Deiss, Katharina; Denzinger, Sabrina; Herrmann, Sebastian; Wettwer, Erich; Weidendorfer, Markus; Becker, Daniel M.; Schäfer, Florian; Wagner, Nicole; Ergün, Süleyman; Schmitt, Joachim P.; Katus, Hugo A.; Weidemann, Frank; Ravens, Ursula; Maack, Christoph; Hein, Lutz; Ertl, Georg; Müller, Oliver; Maier, Lars S.; Lorenz, Kristina

doi:10.1038/nm0216-217c

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(2 citation statements)

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“…In addition, we discovered that the expression of phosphatidylethanolamine‐binding protein 1 (PEBP1) was influenced by exosomal miR‐4,507. Schmid et al reported that PEBP1 gene transfer in a mouse model of heart failure had beneficial effects since the modest overexpression of Raf kinase inhibitor protein, which regulates the expression of miR‐4,507, could produce a well‐tolerated, persistent increase in cardiac contractility . Finally, we predicted that exosomal miR‐3,656 would affect CSK, which is one of the critical negative regulators in the Src family of kinases.…”

Section: Discussionmentioning

confidence: 85%

“…Schmid et al reported that PEBP1 gene transfer in a mouse model of heart failure had beneficial effects since the modest overexpression of Raf kinase inhibitor protein, which regulates the expression of miR-4,507, could produce a well-tolerated, persistent increase in cardiac contractility. 35 Finally, we predicted that exosomal miR-3,656 would affect CSK, which is one of the critical negative regulators in the Src family of kinases. The Src family of kinases regulates inflammation, cell proliferation, motility, and adhesion.…”

Section: Discussionmentioning

confidence: 98%

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Exosomal miRNAs as potential biomarkers for acute myocardial infarction

et al. 2019

IUBMB Life

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microRNAs (miRNAs) can be used as biomarkers for acute myocardial infarction (AMI). However, few reports have focused on the value of exosomal miRNAs in the mechanism of the pathophysiological process from stable coronary artery disease (SCAD) to AMI. Exosomes were isolated via ultracentrifugation after serum samples were collected. The exosomes were then identified by transmission electron microscopy, western blotting, and nanoparticle tracking analysis. The differential expression of miRNAs in exosomes from six AMI and six matching SCAD patients was screened using the Agilent Human miRNA Microarray Kit. Target genes of the candidate miRNAs were predicted via an online miRNA database, Gene Ontology, and Kyoto Encyclopedia of Genes and Genomes analyses. Further validation was conducted through quantitative real‐time polymerase chain reaction with 60 exosome samples. The expression of 13 miRNAs was significantly downregulated in the AMI samples compared with the SCAD samples. In addition, we identified various target genes that are mainly involved in the pathways of cardiac rehabilitation and remodelling. Validation of the expression of candidate miRNAs indicated that exosomal miR‐1915‐3p, miR‐4,507, and miR‐3,656 were significantly less expressed in AMI samples than in SCAD samples, and area under the receiver‐operating‐characteristic curve (AUC) analysis showed that the expression of these miRNAs resulted in good predictive accuracy [miR‐1915‐3p (AUC: 0.772); miR‐4,507 (AUC: 0.684); and miR‐3,656 (AUC: 0.771)], suggesting that these serum exosomal miRNAs might be predictive for AMI at an early stage. Hence, exosomal miRNAs might play an important role in the pathophysiology of AMI and could serve as diagnostic biomarkers.

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Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 98%