Erratum: Corrigendum: Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery

Fumagalli, Fiorenza; Noack, Julia; Bergmann, Timothy J.; Cebollero, Eduardo; Pisoni, Giorgia Brambilla; Fasana, Elisa; Fregno, Ilaria; Galli, Carmela; Loi, Marisa; Soldà, Tatiana; D’Antuono, Rocco; Raimondi, Andrea; Jung, Martin; Melnyk, Armin; Schorr, Stefan; Schreiber, Anne; Simonelli, Luca; Varani, Luca; Wilson-Zbinden, Caroline; Zerbe, Oliver; Hofmann, Kay; Peter, Matthias; Quadroni, Manfredo; Zimmermann, Richard; Molinari, Maurizio

doi:10.1038/ncb3451

Cited by 8 publications

(4 citation statements)

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“…Autophagy receptors are characterized by an LC3-interacting region (LIR). Binding of the ubiquitin-like protein LC3-II to LIR triggers selective autophagy [ 62 ]. The conserved LIR motif was found in the C-terminus of human Sec62 (NDFEMIT, residues 461–367) and is important for Sec62-mediated selective autophagy of the ER components after an unfolded protein response.…”

Section: Additional Functions Of Sec62 and Sec63 In Mammalsmentioning

confidence: 99%

Emerging View on the Molecular Functions of Sec62 and Sec63 in Protein Translocation

Jung

Kim

2021

IJMS

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Most secreted and membrane proteins are targeted to and translocated across the endoplasmic reticulum (ER) membrane through the Sec61 protein-conducting channel. Evolutionarily conserved Sec62 and Sec63 associate with the Sec61 channel, forming the Sec complex and mediating translocation of a subset of proteins. For the last three decades, it has been thought that ER protein targeting and translocation occur via two distinct pathways: signal recognition particle (SRP)-dependent co-translational or SRP-independent, Sec62/Sec63 dependent post-translational translocation pathway. However, recent studies have suggested that ER protein targeting and translocation through the Sec translocon are more intricate than previously thought. This review summarizes the current understanding of the molecular functions of Sec62/Sec63 in ER protein translocation.

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Section: Additional Functions Of Sec62 and Sec63 In Mammalsmentioning

confidence: 99%

Emerging View on the Molecular Functions of Sec62 and Sec63 in Protein Translocation

Jung

Kim

2021

IJMS

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“…Another molecular chaperone, Sec62, is an essential component of the posttranslational translocation machinery in the ER. A study identified Sec62 as a critical molecular component in the maintenance and recovery of ER homeostasis (42). DNAJA1 is an essential cochaperone of mammalian heat shock cognate 70 protein.…”

Section: Discussionmentioning

confidence: 99%

Transcriptome Profiling Analysis of Bovine Vaginal Epithelial Cell Response to an Isolated Lactobacillus Strain

et al. 2019

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Lactobacillus strain SQ0048 isolated from bovine vagina has been shown to exhibit specific adherence to the epithelium and to produce inhibitory substances; however, the underlying mechanisms remain unclear. We cultured and identified primary bovine vaginal epithelial cells treated with SQ0048 to investigate the pathways involved in host cell responses using transcriptome sequencing (RNA-seq). Transcription profiling showed 296 significantly altered differentially expressed genes (DEGs), of which 170 were upregulated and 126 downregulated. Gene Ontology (GO) enrichment analysis of the DEGs revealed significant enrichment of 424 GO terms throughout the differentiation process (P < 0.05). Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis showed that the DEGs were successfully annotated as members of 171 pathways, with 23 significantly enriched KEGG pathways (P < 0.05). A relatively high number of genes were enriched for the endoplasmic reticulum protein processing and interleukin-17 (IL-17) signaling pathways and for antigen processing and presentation. DEGs were verified by quantitative reverse transcription-PCR (RT-qPCR) and determination of which were most enriched for endoplasmic reticulum protein processing pathways, the activation of which might be a major factor underlying Lactobacillus adhesion to cells and pathogenic inhibition. IMPORTANCE Bovine bacterial vaginitis causes infertility, abortion, and postpartum uterine diseases, causing serious economic loss to the dairy industry. The large-scale use of antibiotics destroys normal genital tract flora and hinders the defense mechanisms of the host. Recent research suggests that lactobacilli present in the vaginal microflora of healthy cows constitute the primary microbiological barrier to infection by genital pathogens, exerting a protective role on the reproductive tract via specific adherence to the epithelium and the production of inhibitory substances. Our research identified the mechanisms for Lactobacillus adhesion and pathogenic inhibition, providing valuable information for the development of new probiotics and the discovery of novel therapeutic targets for the prevention of infections in dairy cows.

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“…Thirdly, large bulk proteins and aggregates can be targeted for lysosomal degradation via ER-phagy, which is a selective form of autophagy that protects the cells from excessive ER stress (Mochida et al, 2015;Chino and Mizushima, 2020). ER-phagy receptors, such as FAM134B and SEC62, reside in specific structures of the ER; FAM134B is found in curved portions of the ER membrane while SEC62 is found in flat portions of the ER sheets (Khaminets et al, 2015;Fumagalli et al, 2016). These receptors respond to cell stress resulting from misfolded protein accumulation, starvation, and calcium imbalance within the ER lumen and link their respective ER domains to autophagy machinery (Grumati et al, 2018).…”

Section: Clearance Of Unfolded Proteins Is An Indispensable Component...mentioning

confidence: 99%

Protein quality control of N-methyl-D-aspartate receptors

Benske

Wang

2022

Front. Cell. Neurosci.

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N-methyl-D-aspartate receptors (NMDARs) are glutamate-gated cation channels that mediate excitatory neurotransmission and are critical for synaptic development and plasticity in the mammalian central nervous system (CNS). Functional NMDARs typically form via the heterotetrameric assembly of GluN1 and GluN2 subunits. Variants within GRIN genes are implicated in various neurodevelopmental and neuropsychiatric disorders. Due to the significance of NMDAR subunit composition for regional and developmental signaling at synapses, properly folded receptors must reach the plasma membrane for their function. This review focuses on the protein quality control of NMDARs. Specifically, we review the quality control mechanisms that ensure receptors are correctly folded and assembled within the endoplasmic reticulum (ER) and trafficked to the plasma membrane. Further, we discuss disease-associated variants that have shown disrupted NMDAR surface expression and function. Finally, we discuss potential targeted pharmacological and therapeutic approaches to ameliorate disease phenotypes by enhancing the expression and surface trafficking of subunits harboring disease-associated variants, thereby increasing their incorporation into functional receptors.

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Erratum: Corrigendum: Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery

Cited by 8 publications

References 1 publication

Emerging View on the Molecular Functions of Sec62 and Sec63 in Protein Translocation

Emerging View on the Molecular Functions of Sec62 and Sec63 in Protein Translocation

Transcriptome Profiling Analysis of Bovine Vaginal Epithelial Cell Response to an Isolated Lactobacillus Strain

Protein quality control of N-methyl-D-aspartate receptors

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