“…DNA-Encoded Library (DEL) technology is based on the concept from Brenner and Lerner ( Brenner and Lerner 1992 ) and it is commonly used in the pharmaceutical industry to identify novel chemical matter that binds and modulates specific protein targets ( Melkko et al, 2004 ; Melkko et al, 2007 ; Clark et al, 2009 ; Kleiner et al, 2011 ; Franzini et al, 2014 ; Salamon et al, 2016 ; Goodnow et al, 2017 ; Favalli et al, 2018 ; Neri and Lerner 2018 ; Ottl et al, 2019 ; Yuen et al, 2019 ; Zhao et al, 2019 ; Kunig et al, 2021 ; Shi et al, 2021 ). During the past decade, the use of DEL technology provided a great opportunity to identify drug-like compounds that can bind selectively to a variety of target proteins ( Deng et al, 2012 ; Gentile et al, 2012 ; Disch et al, 2013 ; Samain et al, 2015 ; Seigal et al, 2015 ; Harris et al, 2016 ; Belyanskaya et al, 2017 ; Dawadi et al, 2020 ; Chamakuri et al, 2021 ).…”