2009
DOI: 10.1038/nchembio1009-772
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Erratum: Design, synthesis and selection of DNA-encoded small-molecule libraries

Abstract: In the version of this article initially published, the IC 50 values in the table in Figure 3c were listed as nM instead of µM. The error has been corrected in the HTML and PDF versions of the article. 772volume 5 number 10 october 2009 nature chemical biology e r r ata

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Cited by 9 publications
(10 citation statements)
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“…The vast majority of chemicals are fine chemicals produced at small or very small scale, with an emphasis on quality and purity. An ultimate example is the synthesis of highly-diverse combinatorial libraries containing billions of different structures with as few as 1000 copies of every structure [4]. Until recently, batch production of fine chemicals was the only available option.…”
Section: Small-scale Continuous-flow Synthesismentioning
confidence: 99%
“…The vast majority of chemicals are fine chemicals produced at small or very small scale, with an emphasis on quality and purity. An ultimate example is the synthesis of highly-diverse combinatorial libraries containing billions of different structures with as few as 1000 copies of every structure [4]. Until recently, batch production of fine chemicals was the only available option.…”
Section: Small-scale Continuous-flow Synthesismentioning
confidence: 99%
“…DNA-Encoded Library (DEL) technology is based on the concept from Brenner and Lerner ( Brenner and Lerner 1992 ) and it is commonly used in the pharmaceutical industry to identify novel chemical matter that binds and modulates specific protein targets ( Melkko et al, 2004 ; Melkko et al, 2007 ; Clark et al, 2009 ; Kleiner et al, 2011 ; Franzini et al, 2014 ; Salamon et al, 2016 ; Goodnow et al, 2017 ; Favalli et al, 2018 ; Neri and Lerner 2018 ; Ottl et al, 2019 ; Yuen et al, 2019 ; Zhao et al, 2019 ; Kunig et al, 2021 ; Shi et al, 2021 ). During the past decade, the use of DEL technology provided a great opportunity to identify drug-like compounds that can bind selectively to a variety of target proteins ( Deng et al, 2012 ; Gentile et al, 2012 ; Disch et al, 2013 ; Samain et al, 2015 ; Seigal et al, 2015 ; Harris et al, 2016 ; Belyanskaya et al, 2017 ; Dawadi et al, 2020 ; Chamakuri et al, 2021 ).…”
Section: Introductionmentioning
confidence: 99%
“…DELs are typically less diverse, but there are examples of DELs composed of as many as 10 12 different compounds. 13 The enormous sequence and structure diversities in oligonucleotide libraries along with the availability of adequate screening tools makes such libraries very attractive for in vitro selection of affinity probes and hits in early stage drug discovery. 14,15 Efficient physical partitioning of binders from nonbinders constitutes a major challenge for the field of binder selection from oligonucleotide libraries.…”
mentioning
confidence: 99%
“…There are two major types of oligonucleotide libraries: random-sequence libraries, which are used for the selection of DNA and RNA aptamers, , and DNA-encoded libraries (DELs), which are used for selecting small-molecule ligands. Identifying oligonucleotide sequences of selected aptamers facilitates chemical synthesis of their replicas.…”
mentioning
confidence: 99%