“…Aside from DNA-based walkers, the preferential diffusion of molecules along the higher symmetry axis of a metal surface has also been observed. , Huskens et al reported the gradient-driven diffusion of molecules bearing two adamantane legs across α-cyclodextrin-functionalized surfaces . Processive crown ether migration on an oligoglycine chain and migration of metal atoms on aromatic scaffolds ,, have also been explored. Rearrangement reactions enable the migration of a fragment along a molecule (such as the Claisen , and Cope − rearrangements).…”