Erratum: Hydrocarbons and the evolution of human culture

Abstract

N-terminal bundle of Vh establish that the structure of this domain is regulated by contacts with cytoskeletal proteins. For example, the binding of talin between helices a1 and a2 displaces Vt, and a-actinin binding to Vh also displaces Vt, yet talin and a-actinin bind to Vh in a mutually restricted manner. The exclusive interactions of these a-helices with Vh would thus serve to properly direct cytoskeletal and signalling decisions induced by focal adhesions versus adherens junctions (Fig. 5). The remarkable structural changes in the a-helices of the Nterminal bundle of Vh establish helical bundle conversion as a mechanism of control in signal transduction pathways. Helical bundle conversion is fundamentally different from helical exchange, where the binding of one a-helix simply displaces the binding of another without altering the structure of the displaced helix (Supplementary Fig. S4). Rather, helical bundle conversion provokes dramatic changes in the conformation of a-helices, allowing proteins to expand their repertoire of structures, substrates and functions. A Methods Detailed information on methodological aspects of X-ray data collection, structure determination and refinement is provided as Supplementary Information.