Erratum to: Skeletal muscle expression of bone morphogenetic protein-1 and tolloid-like-1 extracellular proteases in different fiber types and in response to unloading, food deprivation and differentiation

Allen, David L.; Greybeck, Bradley J.; Hanson, Andrea; Cleary, Allison S.; Lindsay, Sarah F.

doi:10.1007/s12576-010-0110-2

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“…and Sirt5 have been implicated in phenotypes such as recovery from nutritional restriction and food deprivation [59][60][61][62]. Another group of genes including Rab3gap1, Cntn6, Dld, Dlg2, Grm5, Hmox2, Accn1, Cntnap2, Hpse2, Il1rapl2, Immp2l, Kalrn and Park2 are associated with neurological diseases such as autism, speech disorder and craniofacial abnormalities [63 -75].…”

Section: Do Iap Insertions Sensitize Host Genes To Environmental Cuesmentioning

confidence: 99%

Is there a role for endogenous retroviruses to mediate long-term adaptive phenotypic response upon environmental inputs?

Sharif

Shinkai

Koseki

2013

Phil. Trans. R. Soc. B

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Endogenous retroviruses (ERVs) are long terminal repeat-containing virus-like elements that have colonized approximately 10 per cent of the present day mammalian genomes. The intracisternal A particles (IAPs) are a class of ERVs that is currently highly active in the rodents. IAP elements can influence the transcription profile of nearby genes by providing functional promoter elements and modulating local epigenetic landscape through changes in DNA methylation and histone (H3K9) modifications. Despite the potential role for IAPs in gene regulation, the precise genomic locations where these elements are integrated are not well understood. To address this issue, we have identified more than 400 novel IAP insertion sites within/near annotated genes by searching the murine genome, which suggests that the impact of IAP elements on local and/or global gene regulation could be more profound than was previously expected. On the basis of our independent analyses and already published reports, here we argue that IAPs and ERV elements in general could have an evolutionary role for modulating phenotypic plasticity upon environmental inputs, and that this could be mediated through specific stages of embryonic development such as placentation during which the epigenetic constraints on IAP elements are partially relaxed.

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Section: Do Iap Insertions Sensitize Host Genes To Environmental Cuesmentioning

confidence: 99%

Is there a role for endogenous retroviruses to mediate long-term adaptive phenotypic response upon environmental inputs?

Sharif

Shinkai

Koseki

2013

Phil. Trans. R. Soc. B

View full text Add to dashboard Cite

show abstract

Erratum to: Skeletal muscle expression of bone morphogenetic protein-1 and tolloid-like-1 extracellular proteases in different fiber types and in response to unloading, food deprivation and differentiation

Abstract: The last name of the second author, Bradley J. Greybeck, was spelled incorrectly.

Cited by 1 publication

References 0 publications

Is there a role for endogenous retroviruses to mediate long-term adaptive phenotypic response upon environmental inputs?

Is there a role for endogenous retroviruses to mediate long-term adaptive phenotypic response upon environmental inputs?

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