“…208,209 Many HA-based formulations (such as hydrogels, lotions, creams, fillers, autologous fat gels, etc .) have been investigated, and have exhibited significant anti-wrinkle, 209,210 anti-aging, 160 space-filling, 211 and facial rejuvenation properties. 212,213 HA-based hydrogel formulations can be used to augment soft tissue, improve skin hydration, stimulate collagen and elastin deposition, and restore facial volume.…”